University Of Alabama At Birmingham

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study tested a two-step treatment for medium-sized kidney tumors (4.1-7 cm). First, doctors blocked the tumor's blood supply, then froze it. The goal was to see if this approach is safe and works well. 25 adults with stage T1b kidney cancer took part. The main focus was on s…

This pilot study explores whether the timing and amount of protein in meals can help preserve muscle health and improve sleep in people with Parkinson disease. Participants follow either a protein redistribution diet (low protein during the day, high protein at dinner) or a prote…

This study looks at whether using a continuous glucose monitor (CGM) alongside standard nutrition and activity advice can improve metabolic health in young people aged 11 and older who have prediabetes and are overweight. Participants wear the CGM intermittently to see how daily …

This study tested whether the drug siltuximab can lessen the severity of cytokine release syndrome (CRS) and neurological side effects (ICANS) that often occur after CAR-T cell therapy for blood cancers like lymphoma and leukemia. Twenty-four participants received siltuximab alon…

This study tested whether eating all meals earlier in the day and getting bright light therapy at specific times can improve blood sugar control in adults with type 2 diabetes. Researchers measured blood sugar, insulin, and other health markers in 190 participants. The goal was t…

This study tested a simple tool that helps doctors choose the right stop-smoking medicines for people living with HIV. 371 smokers from three clinics took part. The goal was to see if the tool helped more people quit smoking for at least a week.

This study tested whether psilocybin, the active ingredient in magic mushrooms, could help people reduce or stop using cocaine. Forty adults who wanted to quit cocaine were given either psilocybin or a placebo (diphenhydramine, an antihistamine) in a controlled setting. Researche…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Researchers measured cha…

This early-phase trial tested the drug rituximab in 3 people with ocular cicatricial pemphigoid, a rare autoimmune disease that causes scarring in the eye and can lead to blindness. The goal was to see if the drug could stop further scarring when standard treatments had failed. T…

This early-stage trial tested an oral drug called NTX-301 in 22 adults with certain blood cancers (MDS, AML, or CMML) that had not responded to prior treatments. The main goal was to check safety and find the right dose. Researchers also looked for signs that the drug might help …

This study looked at 45 people with osteoporosis caused by long-term steroid use. Participants had stopped taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which timing and drug best controlled bone loss markers. …

This study tested whether weighing yourself daily with a wireless scale can help adults with obesity manage their weight. About 400 people from primary care clinics took part. They were asked to weigh themselves each day and see their weight trend on the scale's display. The goal…

This phase 2 trial tested the drug crizotinib in 12 people with neurofibromatosis type 2 (NF2) who had growing tumors in the ear area called vestibular schwannomas. Participants took crizotinib pills daily for up to 12 months. The main goal was to see if the drug could shrink the…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study tested a combination of plasma exchange, rituximab, and intravenous immunoglobulin in 82 people with a sudden, severe worsening of idiopathic pulmonary fibrosis (IPF). The goal was to see if this treatment could improve survival compared to usual care with antibiotics …

This early-phase study tested whether adding a new drug called LDE225 to standard chemotherapy (paclitaxel) is safe for women with ovarian cancer that no longer responds to platinum-based treatments. Fifteen participants were monitored for side effects and to find the best dose. …

This study tested a combination of three drugs (letrozole, everolimus, and TRC105) given before surgery to postmenopausal women with hormone-receptor-positive, HER2-negative breast cancer. The goal was to see if the combo was safe and could shrink tumors. Fifteen women with stage…

This study tested whether taking a harmless bacterium called Oxalobacter formigenes could help it live in the gut and reduce the amount of oxalate passed in urine. High urine oxalate is a major risk factor for calcium oxalate kidney stones. Twenty-six healthy adults who did not a…

This pilot study tested a combination of two drugs, veliparib and lapatinib, in 20 people with metastatic triple negative breast cancer that had already been treated. The main goal was to see how safe the combination is and how many patients respond. All participants received the…

This study tested whether 10 weeks of stationary bike exercise could improve brain health and lower blood pressure in adults aged 35-65 with hypertension and a BMI of 25 or higher. Participants were assigned to moderate or high-intensity exercise sessions. The main goal was to se…

This study tested a special diabetes education program for adults with type 2 diabetes and physical disabilities. The program included health coaching and educational materials, either through a tech platform or email. Researchers measured quality of life, distress, and self-conf…

This study tested a personalized, family-focused diabetes coaching program using artificial intelligence for people with Type 2 diabetes and physical disabilities. The goal was to improve blood sugar control and quality of life. 90 participants completed the program, which was de…

This study looked at whether having a peer coach (a trained person like you) helps people with obesity lose more weight than trying on their own. 375 adults aged 21-75 with a BMI between 30 and 50 took part. The main idea was to see if coach support leads to greater weight loss t…

This study tested whether an AI-powered health coach and gamification could help people with type 2 diabetes better manage their blood sugar. 88 participants in rural areas received weekly automated coaching calls and goal-setting. The main goal was to see if this approach is fea…

This study tested two weight loss programs in 223 overweight or obese adults aged 21-75. One group followed a fixed calorie reduction plan, while the other varied their calorie intake. The goal was to see which approach leads to more weight loss over time.

This study tested three football-based programs for teen girls in Zambia to improve HIV testing, birth control use, and mental health. Over 2,100 girls from 32 schools took part. The programs aimed to make it easier for girls to get sexual health services and stick with HIV treat…

This study tested whether giving higher doses of radiation over five sessions is safe for people with brain metastases that are 2 to 6 cm in size. These larger tumors are often too risky for a single high-dose treatment. The trial enrolled 13 adults and aimed to find the highest …

This study tested whether community health workers can help Black postpartum patients who had preeclampsia or other pregnancy complications. 61 participants were split into two groups: one received usual care, the other also got support from a community health worker. The goal wa…

This study tested whether artificial intelligence (AI) can help doctors accurately identify breast tumors on MRIs that use a lower dose of gadolinium contrast dye. Reducing the dose may lower the amount of gadolinium deposited in the brain. The study included 20 women—half with b…

This study tested a new rapid HIV test for infants in Zambia that gives results in under an hour, compared to standard lab tests that take weeks. Researchers wanted to see if faster diagnosis would lead to more babies starting treatment sooner. Over 1,600 HIV-exposed infants were…

This study tested a portable device called the Infrascanner that uses light to check for expanding brain bleeds in people with traumatic brain injury. About 400 participants who had a head injury and a brain bleed seen on a CT scan were monitored hourly with the scanner. The goal…

This study looked at whether limiting when you eat (time-restricted eating) can improve blood sugar control and heart health in adults with prediabetes. 108 participants were assigned to eat only between 8am-3pm, 1pm-8pm, or a normal 12-hour eating window for 8 weeks. All meals w…

This study tested a 12-month telephone-based counseling program, supported by community health workers, to help people in rural Alabama become more physically active. The goal was to increase moderate-to-vigorous activity as a way to prevent cancer. 245 participants who were not …

This study tested whether teaching pregnant women about CMV risks and protective behaviors could prevent them from catching the virus. 582 women were enrolled early in pregnancy. The intervention involved brief counseling sessions. The goal was to reduce CMV infections that can c…

This study tested a simple checklist and peer coaching program for people who inject drugs and are hospitalized with serious infections. The goal was to see if these tools could help start HIV prevention medication (PrEP) and addiction treatment. Sixty HIV-negative adults with op…

This study tested whether a daily application of diclofenac gel, a common anti-inflammatory drug, can reverse certain biomarkers in the skin that are linked to non-melanoma skin cancer. Twenty-four adults at risk for skin cancer applied the gel for 30 days, and researchers took s…

This study tested whether a combination of two FDA-approved creams (diclofenac and DFMO) can prevent new non-melanoma skin cancers in people who have already had them. 64 participants applied the creams or a placebo to their arms for 9 months. The goal was to see if the treatment…

This study tested a communication tool to help women in rural Alabama learn about PrEP (a daily pill that prevents HIV). 67 HIV-negative women at risk for HIV took part. The goal was to see if the tool helped more women get referred to and start PrEP.

This study tests whether teaching pregnant women about hygiene habits can reduce their risk of catching cytomegalovirus (CMV) and passing it to their baby. Researchers will enroll 200 pregnant women in Brazil and provide counseling on behaviors like handwashing. The goal is to cu…

This study tested a school-based education program for middle school students in three Alaska communities to prevent paralytic shellfish poisoning (PSP). The program taught kids about local shellfish toxins, safe harvesting practices, and traditional knowledge. Researchers measur…

This study tested whether home visits by male-female pairs of health workers could encourage pregnant women and their male partners to get tested for HIV together. About 1,600 couples in Kenya took part. The goal was to increase couple HIV testing and prevent transmission from mo…

This study tests whether three natural supplements—curcumin (from turmeric), resveratrol (from grapes), and stinging nettle—can improve physical and mental health in veterans with Gulf War Illness. 390 veterans from across the U.S. take part from home, reporting their symptoms on…

This study tested whether a noninvasive device that gently stimulates a nerve in the ear (taVNS) could help breast cancer patients with insomnia. Twenty adults with stage I-IV breast cancer who had trouble sleeping for at least three months took part. The main goal was to see if …

This study looked at whether giving tranexamic acid (TXA) during jaw surgery can reduce the need for deliberate hypotensive anesthesia (DHA), a technique that lowers blood pressure to control bleeding but carries risks like stroke or kidney injury. Researchers studied 115 patient…

This study tested whether 20 hours of computer-based executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. About 119 participants were split into a training group and a no-contact control g…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study tested whether giving monthly reimbursements to women with breast cancer in clinical trials could reduce their financial hardship. Thirty-nine participants received payments for trial-related expenses, and researchers tracked how many completed the study and surveys. T…

This study tested a program called ADAPT HF, which uses a lay coach or self-guided materials to help Black adults with advanced heart failure manage pain. Ten participants completed weekly sessions covering pain education, relaxation, social support, and coping. The goal was to s…

This study looked at whether having a therapy dog present can reduce pain and anxiety in children ages 3 to 10 who are having pins removed from their elbow after a fracture. Researchers measured pain using a child-friendly faces scale and anxiety with a standard behavior scale. T…

This pilot study tested a mindfulness-based diabetes education program for adults with type 2 diabetes who feel overwhelmed by their condition. Thirty-six participants were randomly assigned to either the mindfulness program or standard diabetes education. The main goal was to se…

This study tested whether using the GAIMplank, a special video game controller, could help adults with mobility impairments become more physically active. Six participants played active video games over six weeks. Researchers measured changes in physical activity and function to …

This study tested a structured educational program called the Myeloma Pack for people with multiple myeloma. The goal was to see if it could reduce anxiety and depression and improve quality of life. 85 patients took part while receiving standard cancer treatment. Researchers mea…

This study tested whether a 6-week home-based virtual reality exercise program is acceptable and beneficial for young people with cerebral palsy who are overweight and inactive. Four participants used a VR headset to play active games. Researchers measured changes in body composi…

This study tested a high-intensity home exercise program for children with cerebral palsy, using rhythmic arm movements set to music. 42 children aged 6-17 participated, with parents helping to ensure safety. The goal was to see if this fun, accessible program could improve cardi…

This study tested whether playing virtual reality games focused on exercise and mindfulness could help children with cancer be more active and feel better. Eleven kids participated in an 8-week program either right away or after a wait. Researchers measured steps per day and over…

This study tested whether a 6-week exercise program could improve memory in 71 adults with idiopathic generalized epilepsy. Participants either exercised or did nothing extra, and researchers measured memory and brain changes. The goal was to see if exercise helps memory and if t…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury. One program used movement to music, the other standard exercises. Researchers measured physical activity levels and pain to see which approach worked better.

This study tested whether a video-based exercise program is practical and acceptable for adults with cystic fibrosis after a flare-up. Nine clinically stable patients participated. The goal was to see if patients would join and stick with the program, not to measure health outcom…

This study tested whether a special thermo-active knee sleeve (Reparel™) plus a standard corticosteroid injection works better than a plain compression sleeve plus the same injection for knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were followed…

This study tested whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. 70 women were randomly assigned to receive either the QL block or standard enhanced recovery care. Researchers meas…

This early-phase study tested deucravacitinib, an oral drug, for treating nail psoriasis. The goal was to see if it improves nail appearance and symptoms. Only one person took part, and researchers measured changes in nail psoriasis severity over 48 weeks. Because it's so small, …

This study tested whether starting a structured exercise program combined with behavioral counseling during a hospital stay for cystic fibrosis (CF) is feasible. Three adults with CF who were hospitalized for a lung flare-up took part. The goal was to see if this approach could h…

This study tested a distance-learning program for family caregivers of people with Alzheimer's dementia or traumatic brain injury. The goal was to reduce care-resistant behaviors like agitation and aggression, and improve quality of life for both patients and families. 88 caregiv…

This study tested a new FDA-approved sedative, remimazolam, against the standard drug propofol for people having a heart ultrasound called TEE. The goal was to see if remimazolam keeps blood pressure and heart rate more stable. 105 adults took part, and researchers measured vital…

This study looked at whether a gentle electrical stimulation of the vagus nerve through the ear, combined with physical therapy, can help people with Parkinson's disease move better and feel better. Twenty-five adults with Parkinson's who could walk without help took part. The go…

This early study tested a new way to deliver a substance that helps blood vessels relax, potentially lowering blood pressure. Fourteen healthy adults took a mixture placed under the tongue. Researchers measured changes in blood pressure and related chemicals in the blood to see i…

This study tested a remote coaching program called PRISM to help women with breast cancer build resilience and improve their quality of life. 43 women with early-stage or metastatic breast cancer took part. The program focused on stress management, goal-setting, and positive thin…

This study tested a telephone-based program called EPIC, where nurse coaches guide older adults with COPD and their caregivers through sessions on managing symptoms and planning care. The goal was to see if the program is feasible and acceptable. Fifty participants were split int…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study tested whether delivering healthy meals to the homes of low-income women with obesity could help them manage weight after giving birth. Eleven women received 10 meals per week plus remote support. The goal was to see if the program was practical and acceptable, not to …

This study tested a 4-hour acceptance and commitment therapy (ACT) workshop in 52 women with obesity. The workshop taught skills like clarifying values and taking committed action to support healthy eating and physical activity. Researchers measured changes in psychological flexi…

This study tested a resilience-building program called RISE+ in 106 people over 50 living with HIV. Participants watched videos and did activities to improve coping skills, optimism, and social connections. The goal was to see if the program helps them handle daily stress better …

This study looked at how eating high or low amounts of oxalate (a natural compound in many foods) affects urine crystals and immune cells in healthy adults. Fourteen participants followed two controlled diets to see if oxalate changes crystal formation and immune function. The go…

This study looked at whether starting feeding early in premature babies (born between 28 and 32 weeks) helps them reach full feeding sooner. 102 babies took part. The goal was to see if early feeding reduces the need for IV nutrition and improves growth.

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked at whether obesity increases the body's production of oxalate, a substance that can lead to kidney stones. 58 adults without a history of kidney stones ate a special low-oxalate diet for 4 days and provided urine samples. Researchers measured oxalate levels to s…

This study tested whether virtual reality (VR) training can teach people with low vision how to cross streets safely. 117 participants were split into three groups: VR training, training with a human instructor on real streets, or watching educational videos. Their street-crossin…

This study looked at why low-income African American women are not physically active. Researchers worked with 46 women to understand their barriers and develop a customized fitness education program called BeFit. The goal is to create a program that fits their lives and helps the…

This study tested whether community programs—like family support and neighborhood improvements—can improve social ties and reduce risky behaviors in youth. Researchers enrolled 915 mothers and their children in Birmingham, Alabama. They measured things like school suspensions, sm…

This study tested whether an 8-week SKY breath meditation program is practical and beneficial for healthy adults. Researchers measured stress, anxiety, and happiness using surveys and wearable devices, and also looked at changes in blood markers. The goal was to see if this simpl…

This small pilot study looked at whether a short exercise program could help older adults (ages 55-75) with high blood pressure improve their thinking skills. Researchers measured changes in fitness, eye blood vessels, and blood markers. The goal was to see if exercise might reve…

This completed study measured specific blood proteins in 75 adults with COVID-19 to see if they are linked to severe outcomes like ICU admission, breathing support, or organ failure. Researchers analyzed stored blood samples to look at markers that affect blood vessel health. The…

This completed study from the University of Alabama at Birmingham involved 200 women with metastatic or early-stage breast cancer. Researchers conducted interviews and focus groups with patients, nurses, and doctors to understand how treatment decisions are made, including the op…

This study gave healthy adults a nasal flu vaccine to safely mimic a mild flu infection. Researchers then measured virus levels and immune responses in nasal samples. A small group also had lung function tests. The goal was to create a reliable model for studying flu without caus…

This study looked at whether video or phone visits (tele-rheumatology) work as well as in-person visits for people with rheumatic diseases like arthritis. Over 650 adults took part, and researchers measured how satisfied they were with each type of visit and which they preferred.…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This completed study tested whether a mobile app plus weekly group sessions led by Black women could help young Black men who have sex with men start taking PrEP, a daily pill that prevents HIV. Thirty-seven participants were split into two groups: one used only the app, while th…

This study looked at how to make HIV prevention pills (PrEP) more available to women. Researchers surveyed over 1,300 patients and their doctors at gynecology clinics to understand what helps or hinders getting a prescription. The goal was to learn how to better offer PrEP during…

This completed study tested whether changing the language in MRI reports can reduce the nocebo effect—where negative words in medical reports can make people feel worse. Researchers studied 18 adults with lower back pain who were getting an MRI. They compared standard reports to …

This study looked at over 5,000 adults in Zambia to find out how many have hepatitis B and how many need treatment. Researchers tested people in their homes and then did more tests on those who tested positive. The goal was to gather information, not to test a new treatment or cu…

This study monitored 219 adults with severe COVID-19 who needed a ventilator for at least 72 hours. Researchers checked for serious fungal infections, especially aspergillosis, using standard diagnostic methods. The goal was to learn how common these infections are and what puts …

This study looked at how voice and swallowing change after a second neck spine surgery. Two hundred patients had their vocal cords and swallowing checked before and about three weeks after surgery. They also filled out a short quality-of-life survey. The goal was to better unders…

This study tested a new AI-assisted telehealth program designed to help adults with physical disabilities manage chronic conditions like heart disease, diabetes, and lung disease. Researchers wanted to see if the platform could improve quality of life, physical activity, and medi…

This study looked at stem cells taken from two different areas of the gums (the front and back of the palate) to see which ones are better at forming bone and other dental tissues. Researchers collected gum tissue from 7 people and grew the cells in the lab to test their ability …

This study looked at how the antibiotic amoxicillin works in pregnant women to help prevent passing syphilis to their babies. Researchers measured drug levels in the blood of 13 pregnant women during the second and third trimesters and after birth. The goal was to find the right …

This study tested a training program for family medicine doctors in Alabama to help them talk about HIV and STI prevention with teenage girls and young women. 46 doctors took part and completed surveys before and after training to see if their knowledge and practices changed. The…

This study measured the pressure on the tailbone (sacral area) from two different hospital bed systems: a low air loss mattress and a standard hospital mattress. 18 healthy adults were tested lying flat and with the head of the bed raised 30 degrees. The goal was to see which bed…

This study looked at new ways to measure and train eye movements in 21 people with macular degeneration, a condition that causes central vision loss. The goal was to see if training could help them use their remaining side vision more effectively. The research focused on understa…

This study tested whether using text messages and community health workers can improve pregnancy care for Black women. 40 pregnant women participated to see if they liked these extra supports. The goal is to find simple ways to reduce health gaps and help more babies be born heal…

This study looked at whether a school program called MindUP, which teaches mindfulness, can improve mental health and school performance in 5th to 8th graders. About 68 students from Alabama schools took part. Researchers measured changes in anxiety, attention, and stress to see …

This study tested a computerized decision-aid called SMILE that gives lupus patients information about their disease and treatment options. Nearly 1,900 adults with lupus from multiple clinics used the tool during their visits. The main goal was to see how many eligible patients …

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This study worked to improve how doctors estimate kidney function in people with sickle cell disease. Researchers measured actual kidney function in 120 patients and used that data to develop a new formula tailored to sickle cell. The goal is to replace current equations that wer…

This completed study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Participants wore sleep trackers, kept sleep diaries, and underwent pain tests. The goal was to understand if poor sleep drives pain and inflammation, which could ma…

This study looked at whether certain vitamin D receptor gene variations are linked to non-melanoma skin cancer risk in an Alabama population. Researchers compared 200 people aged 50 and older, some with skin cancer and some without, by analyzing their DNA from blood samples. The …

This study tested a website called RecTech Match, combined with health coaching calls, to help people with physical disabilities find and engage in physical activities. Seven adults with mobility-limiting disabilities participated. Researchers measured physical activity levels, b…