University Of Alabama At Birmingham

This study tested whether a smartphone app that uses artificial intelligence (AI) and game-like features can help people with type 2 diabetes better manage their blood sugar. The app provided personalized health coaching and was designed to work even in rural areas with limited p…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing difficult. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Resear…

This study tested a two-step treatment for people with medium-sized kidney tumors (4.1-7 cm). First, doctors blocked the tumor's blood supply, then froze it. The goal was to see if this approach is safe and works well. 25 people took part, and researchers monitored for any seriou…

This study tested a combination of two drugs, veliparib and lapatinib, in 20 people with metastatic triple negative breast cancer who had already tried other treatments. The goal was to see if the combo was safe and could shrink tumors. Participants received both drugs, not a pla…

This study tested a personalized, family-focused telecoaching program that uses artificial intelligence to help people with Type 2 diabetes and physical disabilities better manage their blood sugar. About 90 participants took part in the program, which focused on lifestyle change…

This study tested the drug crizotinib in 12 people with neurofibromatosis type 2 (NF2) who had growing tumors on their hearing nerves. The goal was to see if the drug could shrink these tumors. Participants took crizotinib pills daily for up to 12 months. The study is now complet…

This study tested two types of counseling—brief and in-depth—against usual care to help 680 people living with HIV in Zambia reduce unhealthy alcohol use and improve mental health. The goal was to see if these therapies help more people achieve HIV viral suppression (a low level …

This study tested a simple tool that helps doctors choose the right medicines to help people with HIV stop smoking. 371 participants who smoked at least 5 cigarettes a day took part. The tool aimed to increase the number of people who quit smoking for at least 7 days.

This study tested a combination of three drugs (letrozole, everolimus, and TRC105) given before surgery to postmenopausal women with newly diagnosed, hormone-receptor-positive, HER2-negative breast cancer. The goal was to see if the drugs were safe and could shrink tumors. The st…

This early-stage study tested an oral medication called deucravacitinib for nail psoriasis in one adult participant. The goal was to see if the drug could improve nail appearance and reduce severity over 48 weeks. The study was completed but only enrolled one person, so results a…

This study tested a treatment combining plasma exchange, rituximab, and intravenous immunoglobulin in 82 people with idiopathic pulmonary fibrosis experiencing sudden, severe worsening. The goal was to see if this approach could improve survival by targeting harmful antibodies. T…

This study tested two approaches—weight-focused (aiming for weight loss) and weight-neutral (focusing on physical activity without weight loss goals)—to improve metabolic health in Black adults with stage 1 obesity and related conditions like high blood pressure or prediabetes. F…

This study looked at whether limiting when you eat (time-restricted eating) can improve blood sugar and heart health in adults with prediabetes. Over 100 participants were assigned to eat only between 8am-3pm, 1pm-8pm, or a normal 12-hour window for 8 weeks, with all meals provid…

This study looked at how 10 weeks of moderate versus intense exercise affects brain health, blood pressure, and eye blood vessels in 35 adults aged 35-65 with hypertension and a BMI of 25 or higher. Participants used smartphone apps to track workouts. The goal was to see if exerc…

This early-phase trial tested the drug rituximab in 3 people with ocular cicatricial pemphigoid, a rare autoimmune disease that scars the eye and can lead to blindness. The goal was to see if rituximab could stop further scarring when standard treatments had failed. The study mea…

This study tested an enhanced football-based program for over 2,000 teenage girls in Zambia. The program added HIV self-testing, birth control information, and access to a nurse to encourage more teens to get tested for HIV and use prevention services. The goal was to help those …

This early-stage study tested an oral drug called NTX-301 in 22 adults with certain blood cancers (MDS, AML, or CMML) that had not responded to prior treatment. The main goal was to see if the drug is safe and tolerable, while also checking for any signs that it might help contro…

This study looked at two weight loss programs for adults with overweight or obesity. One program told people to cut a fixed number of calories each day, while the other varied the calorie target. The goal was to see which approach helped people lose more weight.

This study tested whether adults with obesity who weigh themselves every day using an electronic scale can prevent further weight gain. About 400 participants from primary care clinics received a scale and were asked to weigh daily. The goal was to see if this simple habit helps …

This early-phase study tested a new compound given under the tongue to see if it can lower blood pressure by boosting nitric oxide levels. Fourteen healthy adults took part. The goal was to measure changes in blood pressure and related chemicals in the blood. This approach might …

This study looked at 45 adults with osteoporosis caused by long-term steroid use. Participants stopped taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which switch timing better controlled bone turnover and helpe…

This early-stage trial tested whether adding a new drug called LDE225 to the standard chemotherapy paclitaxel is safe for women with ovarian cancer that no longer responds to platinum-based treatments. Fifteen women participated. The main goal was to check for side effects and fi…

This study tested whether having a peer coach (a trained person like you) helps people with obesity lose more weight than trying on their own. 375 adults aged 21-75 with a BMI between 30 and 50 took part. The program focused on support and guidance through regular sessions and ca…

This study tested a portable device called the Infrascanner to monitor people with traumatic brain injury. The goal was to see if it could accurately detect when a brain bleed gets worse, without needing repeated CT scans. About 400 participants with a confirmed brain bleed were …

This study tested whether artificial intelligence (AI) can help doctors accurately identify breast tumors on MRI scans even when a lower dose of the contrast agent gadolinium is used. Twenty women—half with benign findings and half with breast cancer—participated. The goal is to …

This study tested a communication tool to help women at risk for HIV learn about PrEP (a daily pill that prevents HIV) and get referrals to clinics. 67 HIV-negative women in rural Alabama participated. The goal was to see if the tool was easy to use and if it helped more women st…

This study tested a school-based educational program to help middle school students in Southeast Alaska learn how to safely harvest clams and avoid paralytic shellfish poisoning. About 50 students from three school districts took part in lessons that combined cultural practices, …

This study tested whether a topical gel containing diclofenac can reverse certain biomarkers linked to non-melanoma skin cancer, potentially preventing the disease. Twenty-four adults at high risk applied the gel once or twice daily, and researchers measured changes in skin bioma…

This study tested a simple checklist for hospital staff to help people who inject drugs get HIV prevention medicine (PrEP) and addiction treatment. Researchers worked with 60 HIV-negative adults with opioid use disorder at a hospital in Alabama. The goal was to see if this approa…

This study looked at how to make HIV prevention medication (PrEP) more available to women through their regular gynecology clinics. Researchers surveyed over 1,300 patients and their doctors to understand what works best. The goal is to make it easier for women to get PrEP as par…

This study tested whether applying two FDA-approved creams (diclofenac and DFMO) to the skin could prevent new non-melanoma skin cancers in 64 people who had already been treated for skin cancer. Participants used the creams or a placebo for a period and were monitored for new sk…

This study tested whether teaching pregnant women about personal hygiene can lower their risk of catching cytomegalovirus (CMV) and passing it to their baby. Researchers enrolled 200 women in Brazil who were already immune to CMV. The goal was to see if counseling could cut conge…

This study tested a program to help young Black men who have sex with men start taking PrEP, a daily pill that prevents HIV. Participants used a mobile app and some also joined weekly group talks led by Black women from their community. The goal was to see if this approach made i…

This study tested a telephone-based exercise counseling program to help inactive adults in rural Alabama become more physically active. 245 participants were randomly assigned to the program or a waitlist. The goal was to see if the program could increase moderate-to-vigorous phy…

This study tested whether a short, in-clinic lesson on reducing risk behaviors can prevent cytomegalovirus (CMV) infection in pregnant women. CMV is a common virus that can harm unborn babies. The study enrolled 582 women early in pregnancy and measured new infections or reinfect…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury: one set to music and one standard routine. Participants were randomly assigned to either program or a control group. The goal was to see if these remote programs could increase physical act…

This study tested a newer sedative drug, remimazolam, against the standard drug propofol for people having a heart ultrasound called a TEE. The goal was to see if remimazolam could keep blood pressure and heart rate more stable during the procedure. 105 adults took part, and rese…

This study tested a distance-learning program that trains family caregivers to reduce care-resistant behaviors (like agitation or aggression) in people with Alzheimer's dementia or traumatic brain injury. About 88 participants and their unpaid caregivers took part. The goal was t…

This study tested whether a structured educational program, called the Myeloma Pack Intervention, could improve quality of life for people with multiple myeloma. 85 patients received the program alongside their regular cancer treatment. The goal was to see if better understanding…

This study tested whether delivering healthy meals to low-income women after childbirth could help them manage their weight. Eleven women with obesity received weekly meals and reported how much they ate. The goal was to see if this approach was practical and acceptable, not to m…

This study tested whether adding a special anti-inflammatory knee sleeve (Reparel™) to a standard corticosteroid injection improves pain, mobility, and daily function in people with knee osteoarthritis. Forty adults with knee OA who chose non-surgical treatment were randomly assi…

This study tested whether 20 hours of executive function training could improve thinking skills and reduce mental ups and downs in adults over 40 with HIV-related cognitive problems. 119 participants were split into a training group and a no-contact control group. The goal was to…

This study tested a telephone-based nurse coaching program called EPIC for older adults (60+) with moderate to severe COPD and their care partners. The program aimed to improve quality of life, mobility, and reduce caregiver burden through early palliative care. Fifty participant…

This study tested a 4-hour acceptance and commitment therapy workshop for women with obesity. The goal was to see if it could help them adopt and maintain healthy eating and exercise habits. Fifty-two women participated, and researchers measured changes in psychological flexibili…

This study tested whether an 8-week home balance therapy program is practical for children aged 4-17 with inner ear problems causing dizziness. Twenty-one children did balance exercises at home 5 times a week, with weekly check-ins from a physical therapist. The goal was to see i…

This study looked at whether a non-invasive device that gently stimulates a nerve in the ear (vagus nerve) can boost the benefits of physical therapy for people with Parkinson's disease. 25 participants completed the study. The goal was to see if this combination could improve mo…

This study looked at whether having a therapy dog present can lower pain and anxiety in children ages 3 to 10 who are having pins removed from their elbow after a fracture. Researchers measured pain using a faces scale and anxiety with a behavior scale. The goal was to see if the…

This study created and tested a diabetes education program for adults with Type 2 diabetes and physical disabilities. 90 participants took part to see if the program could improve their quality of life, reduce diabetes-related distress, and boost confidence in managing their cond…

This study tested whether starting a structured exercise program combined with behavioral counseling during a hospital stay is feasible for adults with cystic fibrosis. Three participants joined the program while hospitalized for a lung flare-up. The goal was to see if this appro…

This study looked at whether a quadratus lumborum (QL) nerve block can lower pain and the need for opioid painkillers after robotic surgery for pelvic organ prolapse. 70 women were randomly assigned to receive either standard enhanced recovery care or a QL block. The main goal wa…

This study tested whether a video-based exercise program is practical and acceptable for adults with cystic fibrosis after a flare-up. Nine participants tried the program at home. The goal was to see if people would join and stick with it, not to measure health changes.

This study tested higher doses of a precise type of radiation (stereotactic radiotherapy) given over five sessions for people with brain metastases that are 2 to 6 centimeters in size. The goal was to find the highest safe dose and to track any side effects. Thirteen adults with …

This study tested whether a noninvasive device that gently stimulates a nerve in the ear (taVNS) could help improve sleep in people with stage I-IV breast cancer. Twenty participants completed the trial, and researchers measured how practical and acceptable the treatment was. The…

This study tested a program to help people over 50 living with HIV build resilience and better cope with daily stress. 106 participants from an HIV clinic used daily text messaging to track their stress and coping skills. The goal was to see if the program improved their resilien…

This study tested an 8-week virtual reality program that combines exercise and mindfulness for children recovering from cancer. Eleven kids participated, either starting right away in the hospital or waiting 8 weeks after discharge. Researchers measured steps per day and overall …

This study tested a program called PRISM, designed to help women with breast cancer build resilience through skills like stress management, goal-setting, and positive thinking. 43 women participated, including those with early-stage or metastatic breast cancer. The goal was to se…

This study tested whether a 6-week home-based virtual reality exercise program is acceptable and beneficial for young people with cerebral palsy who are overweight and inactive. Four participants used a head-mounted display and off-the-shelf games to exercise. Researchers measure…

This study tested a 12-week exercise program set to music for 108 adults with physical disabilities like spinal cord injury, stroke, or multiple sclerosis. Participants were randomly assigned to the music exercise group or a waitlist. The goal was to see if the program improved h…

This study tested whether virtual reality (VR) training can teach people with low vision how to safely cross streets and navigate outdoor spaces. 117 participants were split into three groups: one trained with a VR system, one trained with a human instructor on real streets, and …

This study tested whether a 6-week exercise program can improve memory in adults with idiopathic generalized epilepsy. 71 participants either exercised or did not, and researchers measured memory and brain changes. The goal was to see if exercise helps memory and if benefits last…

This study looked at whether active video games (like using a special balance board) could help adults with physical disabilities become more active. Six participants tried the gaming program for 6 weeks. The goal was to see if it was practical and enjoyable, and if it improved t…

This study tested a high-intensity home exercise program for children with cerebral palsy, using rhythmic movements to music adapted for wheelchair users. 42 children aged 6-17 participated. The goal was to see if this fun, accessible program could improve cardiorespiratory fitne…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined. Patients completed …

This study looked at blood samples from 75 adults with COVID-19 to see if certain markers (VEGF and sFlt-1) are linked to how sick people get. Researchers measured these markers and checked if they were related to serious outcomes like needing a ventilator, organ failure, or deat…

This study looked at how the language used in MRI reports might affect patients with lower back pain. Sometimes, scary or confusing words can make people feel worse or push them toward treatments they don't need—this is called the nocebo effect. Researchers tested whether changin…

This study tested whether a community health worker program could help Black women who had pregnancy complications like preeclampsia better control their blood pressure and prevent future heart disease. The study enrolled 61 women and focused on whether the program was acceptable…

This study tested a computerized decision-aid tool to help people with lupus and their doctors make treatment decisions together. Nearly 1,900 adults with lupus from multiple clinics took part. The main goal was to see how many eligible patients actually used the tool and whether…

This study involved 120 children and adults with sickle cell disease to develop a more accurate way to estimate kidney function. Current tests are not designed for sickle cell patients, so researchers are creating a new equation using biological markers. The goal is to improve ho…

This study looked at a program where cancer patients report symptoms from home using a digital tool, with help from a navigator. Over 6,700 adults receiving cancer treatment took part across multiple clinics. The goal was to see how well the program works, what helps or hinders i…

This study tested a new website designed to help people with physical disabilities find and connect with accessible exercise and recreation programs in their community. Seven adults with mobility-limiting disabilities used the website and provided feedback through surveys and int…

This pilot study tested whether adding mindfulness training to standard diabetes education is practical and helpful for adults with type 2 diabetes who feel high distress about their condition. 36 adults from low-income backgrounds took part in either an 8-week mindfulness-based …

This study tested a new AI-assisted telehealth program designed to help adults with physical disabilities manage chronic conditions like heart disease, lung disease, or type 2 diabetes. 212 participants used the platform to improve their quality of life, physical activity, and me…

This study looked at whether eating less salt before bed can improve blood pressure and body rhythms in people with obesity. Researchers measured blood pressure, body temperature, and sleep-related hormone changes in 53 adults. The goal was to learn how salt timing affects health…

This study looked at whether a breathing meditation called SKY (Sudarshan Kriya Yoga) is practical and helpful for reducing stress and improving well-being. Forty-five healthy adults took part in an 8-week program. Researchers measured stress, anxiety, and happiness using surveys…

This study tested a program where male-female health worker pairs visited pregnant women and their partners at home in Kenya. The goal was to encourage couples to test for HIV together. About 1,600 couples took part, and the study measured how many tested as a couple up to 12 mon…

This study tested over 5,000 adults from Zambian communities to find out how many have hepatitis B and who needs treatment. Researchers looked at infection rates and what factors increase risk. The goal was to better understand the disease in this population, not to test a new tr…

This study tested two approaches to improve pregnancy care for Black women: text message support and help from community health workers. 40 pregnant women participated to see if they would use these services and recommend them to others. The goal is to find simple, cost-effective…

This study tested a training program for family medicine doctors in Alabama. The goal was to help them feel more comfortable talking about sexual health and HIV prevention, including PrEP, with teenage girls and young women. 46 doctors completed surveys before and after training …

This study gave a nasal flu vaccine to 33 healthy adults to mimic a mild flu infection. Researchers then collected nose samples to measure how the virus grows and how the immune system reacts. The goal was to create a safe way to study flu infections in people, not to test a new …

This study looked at whether improving neighborhoods (like cleaning up blight) and offering family support programs can help mothers and their children ages 11-16 living in disadvantaged areas. Over 900 people took part. Researchers measured things like community trust, parent-ch…

This study looked at whether certain gene variations (called VDR polymorphisms) are linked to a higher risk of non-melanoma skin cancer. Researchers compared 200 people aged 50 and older—some with skin cancer, some without—to see if these genes play a role. The goal is to better …

This study looked at how the antibiotic amoxicillin behaves in the bodies of pregnant women. The goal was to find the right dose to prevent passing syphilis to the baby. Thirteen pregnant women took part, and researchers measured drug levels in their blood and in the baby's cord …

This study looked at whether a school-based mindfulness program (MindUP) can improve mental health and thinking skills in 5th to 8th graders. About 68 students from Alabama schools took part. Researchers measured changes in anxiety, attention, stress, and school performance to se…

This study looked at how much money to give women with breast cancer to cover costs from being in a clinical trial. 33 women got monthly payments, and researchers checked if the amount helped reduce their financial worry. They also asked patients what they thought about getting p…

This study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Researchers measured pain sensitivity, sleep patterns, and blood markers. The goal is to confirm that treating insomnia could help reduce pain and inflammation in people livin…

This study gave 26 healthy adults a harmless bacterium called Oxalobacter formigenes to see if it would settle in their gut and reduce oxalate in urine, a key risk factor for kidney stones. Researchers measured urine and stool oxalate levels before and after colonization. The goa…

This study looked at why low-income African American women often do not get enough physical activity. Researchers worked with 46 women who live in public housing to understand their specific challenges. The goal was to create a custom exercise education program called BeFit that …

This study tracked 219 adults with severe COVID-19 who needed a ventilator to breathe. Researchers wanted to see how many also developed serious fungal infections, especially a lung infection called aspergillosis. They used standard tests to check for fungi, but did not give any …

This completed study with 200 participants looked at how to improve shared decision-making for women with metastatic breast cancer. Researchers interviewed patients and healthcare providers to understand what influences treatment choices and how to best share information about pr…

This study tested whether a personalized lifestyle program could help people with obesity and related conditions like prediabetes or high blood pressure improve their insulin resistance. Forty adults received either nutrition or exercise counseling first, and if they didn't impro…

This study tested a new rapid HIV test for babies and young children in Zambia. The goal was to see if faster diagnosis helps more infected infants start antiretroviral therapy (ART) sooner. Over 1,600 HIV-exposed infants took part, and the results showed improved treatment initi…

This small study looked at whether a short exercise program could improve thinking skills and blood vessel health in older adults (ages 55-75) with high blood pressure. Eleven participants exercised on a stationary bike and had their fitness, eye blood vessels, and memory tested …

This study tested new methods to measure and train eye movements in 21 people with macular degeneration and severe vision loss. Participants practiced using a different part of their retina to see, and researchers tracked changes in vision and eye movement over 14 weeks. The goal…

This study looked at stem cells taken from two different parts of the roof of the mouth to see which ones are better at growing bone and other dental tissues. Only 7 people took part, and the goal was to learn how these cells work, not to treat a disease. The findings may help fu…

This study looked at whether video or phone visits with a rheumatologist work as well as in-person visits for people with rheumatic diseases like arthritis. Over 650 adults took part, and researchers measured how satisfied patients were with each type of visit and which they pref…

This study looked at 200 patients who had a second neck surgery from the front. The goal was to see how their voice and swallowing changed after the operation. Researchers checked vocal cords and swallowing with a camera before and about three weeks after surgery, and also asked …

This study measured how much pressure different hospital bed mattresses put on the tailbone area of healthy volunteers. Researchers tested two bed systems with volunteers lying flat and with their head slightly raised. The goal was to gather data to help understand how mattress d…