University Of Alabama At Birmingham

This study tests whether adding extra protein to breast milk during the first two weeks of life helps extremely preterm infants (born at 28 weeks or earlier) gain more lean body mass and develop a healthier gut microbiome. About 150 babies will be randomly assigned to receive eit…

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study tests whether giving extremely preterm infants (born at 28 weeks or less) a higher dose of vitamin D during their first two weeks of life can improve their breathing outcomes. 126 babies will be randomly assigned to receive either a high or low dose of vitamin D. Resea…

This study looks at whether adding extra nutrients (fortification) to breast milk earlier (between days 4-7) helps very preterm infants (born 29-33 weeks) grow better and develop a healthier gut compared to waiting until days 10-14. Eighty infants will be randomly assigned to one…

This early-phase trial tests two drugs, mogamulizumab and brentuximab vedotin, given together to people with a rare type of skin lymphoma (CTCL or mycosis fungoides) that has not responded to prior treatment. The main goal is to see if the combination is safe and to find the best…

This study was designed to test whether a new drug called M4344, combined with the PARP inhibitor niraparib, could be safe and effective for women with recurrent ovarian cancer that had stopped responding to PARP inhibitors. The plan was to enroll women with advanced ovarian, pri…

This study tests whether adding iberdomide (a new oral drug) to standard treatments can eliminate tiny amounts of myeloma cells that remain after a stem cell transplant. About 80 adults with multiple myeloma who still have detectable cancer cells after transplant will receive one…

This study tests whether a moderately low-carb diet can reduce liver fat and improve how the body uses insulin in teenagers with non-alcoholic fatty liver disease (NAFLD) and obesity. About 80 teens aged 10-17 will follow either a carb-restricted or a low-fat diet for 6 months, w…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This study looks at the best way to control blood sugar in pregnant women with diabetes who receive steroids to help their baby's lungs develop before a possible early birth. About 120 women will be randomly assigned to one of three insulin strategies. The goal is to find which a…

This study tests whether a culturally tailored storytelling video, shown on a tablet, can help 200 gout patients—especially African Americans in the Southeast—better understand their condition and stick with long-term treatments like medication, diet, and exercise. The goal is to…

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This study looks at whether taking folic acid supplements can help people living in areas with high arsenic levels get rid of the toxin more quickly and protect their lungs. Researchers will measure arsenic levels in urine and blood and track breathing symptoms over 12 weeks. The…

This pilot study tests whether checking blood pressure at home and talking to a pharmacist weekly by phone can help manage uncontrolled hypertension after an emergency department visit. Twenty-four participants will be split into two groups: one receives the home monitoring and t…

This study tests whether a 13-week home exercise program, done via live video calls, can reduce hospital readmissions in people with COPD. 301 patients who were recently hospitalized for a COPD flare-up will either get the video rehab or standard care. The goal is to see if this …

This study tests a precise, non-invasive radiation treatment (frameless virtual cone radiosurgery) to reduce severe tremors in people with essential tremor or Parkinson's disease who cannot have deep brain stimulation. About 40 participants will receive a single focused dose of r…

This study looks at whether losing weight with a special very low-calorie diet (Optifast) can lower oxalate levels in urine for obese adults who have had calcium oxalate kidney stones. Fourteen participants will eat a low-oxalate diet and provide urine samples before and after th…

This study compares two different incision methods for gum graft surgery to treat receding gums. Twenty-two adults with gum recession and thin gum tissue will receive a graft made from donated skin. The goal is to see which method covers more exposed tooth root and causes less pa…

This study planned to test whether adding acarbose, a drug normally used for diabetes, could improve standard immunotherapy for advanced kidney cancer. The goal was to see if the combination was safe and affected gut bacteria. However, the trial was withdrawn before enrolling any…

This study planned to see if adding the daily pill vibegron to standard Botox bladder injections helps women with overactive bladder that hasn't improved with other treatments. Researchers aimed to compare changes in urgent leaks and symptom distress over 12 weeks. However, the t…

This study tests whether motivational interviewing, a supportive counseling method, can help teenagers aged 14-19 with braces improve their oral hygiene. Participants receive short, non-judgmental conversations to set their own goals for brushing and flossing. The goal is to redu…

This pilot study tests the safety and effectiveness of baricitinib, a drug that targets inflammation, in 15 women with active frontal fibrosing alopecia (FFA). FFA is a condition that causes scarring and permanent hair loss, mainly at the front of the scalp and eyebrows. The stud…

This study tests a new combination of two drugs—niraparib and trastuzumab—in people with metastatic HER2-positive breast cancer, an aggressive form of the disease. The goal is to see if the combo is safe and can shrink tumors or slow cancer growth. About 46 women with advanced ca…

This study tests whether providing 10 home-delivered meals per week, plus brief weekly support, can improve diet quality and promote healthy weight gain in low-income Black pregnant women with overweight or obesity. Seventeen women from Alabama are taking part. Researchers are ch…

This pilot study tests whether taking a daily probiotic supplement for 12 weeks can improve insulin resistance and asthma control in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and asthma symptoms. Only 7 people are enroll…

This early-phase study tests whether a new type of cell therapy, made from a patient's own immune cells that are genetically modified to resist chemotherapy, can be safely given alongside standard chemotherapy for newly diagnosed glioblastoma. About 22 adults with this aggressive…

This study tests whether giving a fixed number of CD3+ T cells (a type of immune cell) during stem cell transplants from sibling donors leads to more predictable outcomes. Researchers want to see if standardizing the dose reduces variation in complications like graft-versus-host …

This study planned to see if placing preterm babies in a plastic bag during kangaroo mother care (skin-to-skin contact) could prevent hypothermia. It aimed to enroll infants born at 32 to 36 weeks. However, the trial was withdrawn before any participants were enrolled, so no data…

This study tests whether providing 10 healthy, home-delivered meals per week plus brief weekly coaching can help pregnant women with overweight or obesity avoid gaining too much weight. Researchers will track weight changes and also measure food security and stress. The study is …

This early-phase study tests whether adding loncastuximab tesirine to the standard drug acalabrutinib is safe and effective for people with chronic lymphocytic leukemia (CLL). About 24 adults with CLL will receive the combination to find the best dose and see if it can make the c…

This early-stage trial tests a single dose of M032, a genetically modified herpes simplex virus that produces IL-12, in 29 patients with recurrent or progressive brain tumors (glioblastoma, anaplastic astrocytoma, or gliosarcoma). The virus is infused directly into the tumor area…

This pilot study planned to give sildenafil (the drug in Viagra) to women in labor in low-resource areas, aiming to reduce fetal distress and birth asphyxia. It was designed to test whether the drug could be safely given and to gather data for a larger trial. However, the study w…

This pilot study aimed to see if giving sildenafil (the drug in Viagra) to women in labor could prevent fetal distress, reduce the need for emergency C-sections or forceps deliveries, and lower the risk of newborns needing breathing help. The trial planned to enroll 120 women in …

This study tests whether placing premature or low-birth-weight babies in plastic bags right after birth helps keep them warm. About 182 infants born at 29-36 weeks will be wrapped in plastic bags during resuscitation and for one hour after birth. The goal is to see if this simple…

This study tests whether a campaign designed and run by high school students can increase HPV vaccination in Chambers County, Alabama, which has the state's highest cervical cancer rate. Twenty-nine students will create and spread messages through multiple channels to encourage t…

This phase 3 trial tests whether giving antiviral medication to pregnant women with hepatitis B and their newborns can prevent the virus from passing to the baby. The study involves 450 women and their infants in Africa. The goal is to find a safe and effective way to reduce moth…

This study tests whether making neighborhoods safer and more walkable—adding sidewalks, lighting, green spaces, and community programs—can reduce cancer risk in underserved areas. Researchers will measure stress levels and physical activity in 300 Black residents. The goal is to …

This study tests whether a program using church-based health coaches can help rural Black adults with slightly high blood pressure lower it. Participants from 30 churches in Alabama will get health education and online cooking and exercise classes. Half will also get a health coa…

This phase IIB trial tests whether a low dose of tamoxifen (a hormone-blocking drug) can reduce breast cancer risk in people who received chest radiation therapy before age 40. The study involves 84 survivors and measures changes in breast density as a risk indicator. If successf…

This study tests a program called ENABLE Cornerstone, where specially trained lay coaches provide support to family caregivers of people with advanced cancer. The coaches help caregivers manage stress, improve coping skills, and plan for the future through phone or in-person sess…

This pilot study tests whether a 5-minute virtual reality (VR) greenspace experience can lower stress in 25 adults with mobility impairments. Participants will either engage in a VR nature activity or sit quietly, and researchers will measure stress through surveys and saliva sam…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study planned to test a procedure called transarterial embolization in children aged 2-18 with incurable soft tissue sarcomas. The goal was to block blood flow to tumors using tiny particles, potentially slowing growth or easing symptoms. However, the trial was withdrawn bef…

This study looks at two ways to help women Veterans get nonsurgical treatment for urinary incontinence (bladder leakage) using remote tools like a mobile app and online resources. About 3,200 women Veterans from the Southeast U.S. will take part. The goal is to see which approach…

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study tests whether a 10-week video-based stress management program (VSMART) is practical and helpful for 25 breast cancer survivors in Alabama. Participants join group discussions from home. The goal is to see if the program improves wellbeing and to gather feedback from su…

This study tests a coaching program called CuRB-IT for family caregivers of people with dementia. The program includes 9 video sessions over 12 weeks to help caregivers manage care-resistant behaviors (like refusing help) and improve their own coping skills. About 266 caregivers …

This study looks at whether improving diet quality and reducing calories can help physical function, thinking, pain, fatigue, mood, and anxiety in 100 adults with relapsing-remitting or secondary progressive multiple sclerosis. Participants receive prepared meals and behavioral s…

This study compares using KT Tape plus an arm sling versus a sling alone in 50 children with a broken collarbone. The goal is to see if the tape reduces pain and disability while the bone heals. Kids will rate their pain and complete a questionnaire about daily activities.

This study planned to test very low doses of psilocybin (the active ingredient in magic mushrooms) in adults with moderate to severe demoralization—feelings of hopelessness and meaninglessness often linked to illness or hardship. The goal was to see if these microdoses could impr…

This study tested whether Bodewell eczema products are safe and help improve skin symptoms in adults with atopic dermatitis (eczema). Fifteen participants used the products for 12 weeks. Researchers measured skin clearance and quality of life improvements.

This study compares two approaches to help stroke survivors with mild to moderate thinking problems. Both groups use a web-based computer game that trains how quickly they process information. One group also gets in-lab training on everyday activities, while the other focuses on …

This study tests a program called UPHOLDS to improve quality of life for 64 older adults with advanced heart failure. Participants receive different combinations of coaching, financial help, and a palliative care consultation. The goal is to see which parts of the program are mos…

This pilot study tests whether adding blood flow restriction therapy to standard physical therapy helps elderly patients (65 and older) recover muscle strength and size after hip fracture surgery. Twenty participants will have their thigh and leg measurements, muscle strength, pa…

This study looks at whether a plant-based omega-3 supplement from flaxseed can reduce pain and improve quality of life in children with sickle cell disease. About 30 children aged 5-18 will take flaxseed and report their pain levels. The goal is to see if this natural option is m…

This study was designed to see if a nerve block and numbing medicine at the surgical site could reduce pain after knee arthroscopy. It planned to measure pain scores, opioid use, and sleep quality. However, the trial was withdrawn before enrolling any participants, so no results …

This study tests a 6-month online program designed to help people with multiple sclerosis become more physically active. Participants receive interactive video lessons, a step tracker, and one-on-one video chats with a coach. The goal is to see if the program increases daily acti…

This study tests a precise radiation treatment for trigeminal neuralgia, a condition that causes severe facial pain. Instead of a metal frame screwed into the skull, a special face mask holds the head still while x-rays target the painful nerve. The trial includes 40 adults whose…

This study was designed to see if a combination of PET and MRI scans could detect early signs that treatment is working in people with stage IV HER2-positive breast cancer. The plan was to scan participants up to three times over six months and compare the images to standard meas…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study tests a training program called CASCADE for family caregivers of people with advanced cancer. The goal is to see which parts of the training best help caregivers support patients in making medical decisions. 256 caregivers are taking part in different combinations of c…

This study looks at how ultraviolet (UV) light from the sun can weaken the immune system in human skin, which may help explain how skin cancer develops. Researchers will apply a chemical called DPCP to the skin of 70 healthy adults aged 18-35 to trigger a mild allergic reaction a…

This pilot study looks at whether regularly measuring body fat in very preterm infants (born at 28-32 weeks) can help reduce excess fat gain by 3 months of age. Researchers will use a special machine to measure body composition shortly after birth, at 32 weeks, and again at 36 we…

This study looks at a program where cancer patients report their symptoms from home using a computer or phone. A navigator helps manage those symptoms. The goal is to see if this approach improves patient care and reduces emergency visits. About 3,090 adults with cancer are takin…

This study looks at whether a continuous glucose monitor can accurately measure blood sugar changes after eating a starchy vegetable (potato) with or without herbs and spices. Ten healthy adults without diabetes will wear a glucose monitor for at least 10 days and eat test meals.…

This study looks at how vitamin C (ascorbic acid) turns into oxalate, a key component of kidney stones. Researchers will give a special labeled vitamin C to 136 adults—both with and without kidney stones—and measure how much oxalate ends up in their urine. The goal is to understa…

This study looks at how oxalate, a compound found in spinach, affects the energy use of white blood cells in healthy adults. Researchers will give participants a spinach smoothie and measure changes in immune cell function over five hours. The goal is to better understand how die…

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This study was designed to use a special PET scan to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of neck arteries without symptoms). It aimed to compare inflammation levels between those with high-grade and low-grade narrowing. However…

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study looks at how much oxalate the body naturally makes in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a type of fatty liver. Researchers will collect urine samples from 28 adults after they eat a special low-oxalate diet. The goal is to be…

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study looks at how the kidneys turn a substance called glycolate into oxalate, which can form kidney stones. Fifteen healthy adults will eat a special low-oxalate diet and receive a harmless tracer to track this process. The goal is to better understand how oxalate is made i…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study looks at how four different FDA-approved flu vaccines affect the immune system in 50 adults aged 18-50 and 65-80. Researchers will measure antibody levels and memory B cells to see how age and past vaccination history influence the body's response. The goal is to under…

This study looks at whether it is safe to wait before giving a second round of chemotherapy to adults newly diagnosed with acute myeloid leukemia (AML), even if a mid-treatment bone marrow biopsy shows some remaining disease. About 60 participants will receive standard first chem…

This study asks 30 adults with spinal cord injury about their exercise habits and what they would want in a physical activity program. Researchers will use surveys and interviews to learn what helps people start and keep exercising. The goal is to design better exercise programs …

This study looks at whether older adults with prediabetes have lower brain energy use and slower thinking compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can improve brain energy and processing speed. Twenty participants will under…

This study explores whether wearable devices, like smartwatches, can help monitor symptoms in cancer survivors. Twenty participants will wear a sensor-packed device that tracks temperature, heart rate, sleep, and activity. Researchers will see how many people agree to use the wea…

This study aims to develop a new way to measure how well the sinuses work in people with chronic sinusitis. About 30 adults with chronic sinusitis and a recent bacterial infection will take the drug ivacaftor. The main goal is to see if a special test can detect changes in sinus …

This study looks at whether a coordinated emergency system, like those used for trauma, can help more severe stroke patients get a clot removal procedure called mechanical thrombectomy. Researchers will compare data from before and after the system is put in place across Alabama.…

This study looks at whether a woman's insurance status affects how well her epidural works during a C-section. Researchers will review the medical records of 2,500 pregnant women at the University of Alabama at Birmingham. The goal is to uncover any unfair differences in pain man…

This study looks at how being obese might increase the amount of oxalate your body makes, which can lead to kidney stones. Researchers will give 40 adults (half obese, half not) a special diet and measure their urine oxalate levels. The goal is to understand the link between obes…

This study looks at how obesity changes the way the body handles oxalate, a substance that can form kidney stones. Researchers will give 22 calcium oxalate stone formers a controlled low-oxalate diet and a special tracer to measure oxalate absorption, kidney handling, and natural…

This study tests whether a tele-health navigator program can help more kidney transplant candidates find living donors. About 347 adults with end-stage kidney disease will either get the navigator support or standard care. The goal is to see if remote guidance increases donor scr…

This study was designed to explore whether problems with mitochondria—the energy powerhouses in cells—play a role in causing heart damage in people with sepsis. Researchers planned to compare blood samples from sepsis patients and healthy volunteers to look for links between mito…

This study aimed to see if adding patient questionnaires, staff training, and telemedicine could improve mental health and substance use disorder care for people living with HIV. It was planned for five clinics in Alabama, but the trial was withdrawn before enrolling any particip…

This study looks at how the brain changes and adapts after losing central vision, which happens in conditions like macular degeneration. Researchers are testing different training tasks in 120 healthy adults aged 18-30 to measure improvements in eye movements and focus. The goal …

This study was designed to find early warning signs of high blood pressure in the lungs after mitral valve surgery. Researchers planned to use blood tests and heart imaging to detect problems that could be deadly if missed. The study was withdrawn before enrolling any participant…

This study looks at how sleep and your internal body clock influence blood pressure at night. Researchers will monitor over 1,400 participants using a constant routine protocol—staying awake in a dim room for over 24 hours—to measure melatonin, body temperature, and blood pressur…

This study uses a non-invasive breathing test called forced oscillometry to measure lung function in 600 newborn infants, both full-term and premature, with and without lung conditions like respiratory distress or bronchopulmonary dysplasia. The goal is to better understand how t…

This study follows 156 people experiencing their first episode of psychosis who have never taken antipsychotic medication. Participants receive standard treatment with risperidone or aripiprazole and undergo brain scans four times over 32 weeks. The goal is to identify brain diff…

This study compares a new, less invasive needle-based method (endo-AVF) with traditional surgery for creating arteriovenous fistulas (AVFs) needed for dialysis. About 21 adults will be randomly assigned to one of the two techniques to see if a larger trial is feasible. The goal i…

This study tests whether providing an information letter plus a booklet helps relatives of people with Lynch syndrome decide about genetic counseling and testing. About 185 untested relatives will be randomly assigned to receive either a basic letter or a letter plus a detailed b…

This study looks at blood stem cells (called EPCs) in people with and without diabetes to see if they work differently. Researchers want to know if these cells can predict diabetic retinopathy, an eye disease that can cause vision loss. The study involves 78 adults, including 39 …

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study was designed to test whether a type of talk therapy called acceptance and commitment therapy (ACT) could help men reduce chemsex—using drugs during sex. It planned to enroll 0 participants and was withdrawn before it began. No results or conclusions are available.

This study looks at whether taking antidepressants can reduce gum inflammation in people with chronic periodontitis (gum disease) and depression. Researchers will collect gum fluid and plaque samples from 92 patients during routine dental procedures. The goal is to see if depress…

This study uses a special PET/MRI scan with an investigational tracer called [18F]DPA-714 to see if a heart attack leads to inflammation in the brain. Researchers will compare 6 people who recently had a heart attack with a control group. The goal is to better understand the link…

This lab study compares how much growth factor (PDGF-BB) is released over time from two materials used in bone grafting: platelet-rich fibrin (PRF) from a patient's blood and a commercial product called GEM21S. Researchers will mix these with bone substitutes and measure growth f…

This study looks at how aerobic exercise changes the gut microbiome in breast cancer survivors and whether those changes relate to less fatigue. About 126 women who have finished primary treatment will take part. Researchers will measure gut bacteria from stool samples and track …

This study follows 830 women in Alabama who are at risk for HIV and sexually transmitted infections (STIs). Researchers will use a smartphone app to provide information and resources, and track how many women start using PrEP, a medication that prevents HIV. The goal is to learn …

This study looks at how vision loss from glaucoma affects the daily mobility of older adults. Researchers will give questionnaires to 88 people with glaucoma to measure how far they typically go from home and how they manage in dim light. The goal is to better understand the real…