University Of Alabama At Birmingham

This study tests a student-designed campaign to increase HPV vaccination among teens in Chambers County, Alabama, where cervical cancer rates are high. High school students create and share messages to encourage their peers to get the HPV vaccine. The goal is to see if this appro…

This study looks at whether giving a set number of immune cells (CD3+ T cells) during a stem cell transplant from a sibling donor leads to more predictable results and fewer complications. About 20 adults will receive a fixed dose of these cells. The goal is to see if this approa…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma symptoms, lower insulin resistance, and reduce inflammation in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and lung function. The …

This study looks at whether losing weight with a special meal replacement program (Optifast) can lower the amount of oxalate in the urine of people who are obese and have had calcium oxalate kidney stones. Oxalate is a substance that can form stones. The researchers will measure …

This study looks at whether giving extremely preterm babies (born at 28 weeks or earlier) breast milk with extra protein during their first two weeks of life helps them gain more lean muscle and develop a healthier mix of gut bacteria. About 150 infants will be enrolled and follo…

This study looks at the best way to control blood sugar in pregnant women with diabetes who need steroid shots to help their baby's lungs develop before a possible early birth. Steroids can raise blood sugar, which may be harmful. The trial compares three insulin strategies to fi…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people living with HIV reduce unhealthy alcohol use. About 308 participants in Alabama will receive either the combined program or brief counseling alone. The…

This study helps 200 adults with gout, especially African Americans in the Southeast, get better care through an emergency department program. It focuses on improving treatment for flare-ups and long-term management. The study also aims to increase minority involvement in medical…

This study tests a combination of two drugs, niraparib and trastuzumab, in people with metastatic HER2-positive breast cancer. The goal is to see if the combo is safe and can shrink tumors or slow the disease. About 46 women with advanced cancer that has spread will take part.

This study tests whether eating all meals earlier in the day and getting light therapy at specific times can improve blood sugar control in adults with type 2 diabetes. About 344 participants will follow these routines for several weeks while researchers measure blood sugar, insu…

This study tests whether a video-based pulmonary rehabilitation program, done from home, can reduce hospital readmissions in people with COPD. About 300 adults hospitalized for a COPD flare-up will either receive the telehealth program or standard care. The goal is to see if the …

This pilot study tests whether checking blood pressure at home and talking with a pharmacist weekly can help manage high blood pressure. Twenty-four patients from an ER follow-up clinic will take part; half will use home monitors and get phone check-ins, while the other half rece…

This study tests whether adding iberdomide (taken as a pill) together with other drugs can clear tiny amounts of multiple myeloma that remain after a stem cell transplant. About 80 adults with newly diagnosed myeloma who still have detectable disease after transplant will receive…

This study aimed to see if adding the drug vibegron to Botox injections could better control overactive bladder in women who hadn't improved with other treatments. It planned to compare changes in urgent urine leaks between women getting vibegron plus Botox versus a placebo plus …

This study compares two surgical techniques for treating gum recession, where the gum pulls away from the tooth. The goal is to cover the exposed root and improve gum health. About 22 adults with gum recession will receive either a new incision method (SAMRI) or a standard tunnel…

This study tests whether delivering healthy meals to the homes of pregnant women with overweight or obesity can help them avoid gaining too much weight during pregnancy. Researchers will track weight changes and also look at food security and stress levels. The goal is to see if …

This study aimed to see if using a smartphone exercise app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose sensor and some would also use the exercise …

This study aimed to see if adding the diabetes drug acarbose to standard immunotherapy was safe and could help control advanced kidney cancer. It planned to enroll people with metastatic renal cell carcinoma. However, the study was withdrawn before any participants were enrolled.

This early-phase study tests whether a new cell therapy, made from a patient's own immune cells that are gene-modified to resist chemotherapy, can be safely given to people with newly diagnosed glioblastoma. About 22 participants will receive the therapy directly into the brain w…

This study looks at whether sending healthy meals to the homes of Black, low-income pregnant women can help them eat better and gain the right amount of weight. About 17 women with overweight or obesity will receive meals and be compared to a similar group from hospital records. …

This study tests different weight loss plans for 30 adults with prediabetes and physical disabilities. Participants first try either a high or low carbohydrate diet. After 4 weeks, those who lose less than 2.5% of their body weight get extra help, like exercise coaching or time-r…

This study tests a precise, non-invasive radiation treatment called frameless virtual cone radiosurgery for people with severe tremor from essential tremor or Parkinson's disease who cannot have deep brain stimulation. The goal is to reduce tremor and improve daily activities. Fo…

This study looks at whether adding extra nutrients (fortification) to breast milk early (between days 4-7) helps very preterm infants grow better and have healthier gut bacteria compared to adding nutrients later (days 10-14). About 80 babies born at 29-33 weeks will take part. T…

This study tests the drug baricitinib in 15 women with frontal fibrosing alopecia, a condition that causes scarring hair loss and eyebrow loss. The goal is to see if it safely reduces disease activity and improves symptoms like itching and redness. Participants take the drug and …

This study tests whether placing preterm or low birth weight babies in plastic bags right after birth, along with standard warming care, helps prevent dangerously low body temperature (hypothermia). About 182 infants born between 29 and 36 weeks of pregnancy or weighing 1.4 to 2.…

This early-stage study tests the safety of a lab-modified herpes virus (M032) that delivers an immune-boosting protein (IL-12) directly into aggressive brain tumors. The trial includes 29 adults with recurrent glioblastoma or similar cancers who have already tried standard treatm…

This study looks at whether taking folic acid supplements can help people living in areas with high arsenic levels get rid of more arsenic through their urine. Researchers will measure arsenic in blood and urine before and after 12 weeks of supplementation. They will also track a…

This early-phase study tests adding a targeted drug, loncastuximab tesirine, to the standard treatment acalabrutinib for people with chronic lymphocytic leukemia (CLL). The main goal is to find the safest dose of the combination. Researchers will also check if the combo can make …

This study tested whether giving sildenafil (a blood pressure drug) to women during labor could prevent fetal distress and reduce the need for emergency C-sections or baby resuscitation. It was designed for low-resource countries and planned to include 0 participants before being…

This study tests whether a low dose of tamoxifen, a drug that blocks estrogen, can reduce the risk of breast cancer in people who have had radiation therapy for other cancers. About 84 participants are randomly assigned to receive either low-dose tamoxifen or a placebo. The main …

This study tests a program to prevent high blood pressure in 528 rural Black adults in Alabama who have slightly elevated blood pressure. Participants from 30 churches will receive health education and online cooking and exercise resources. Half of the churches will also get a he…

This study tests whether fixing up neighborhoods—like adding better lighting, sidewalks, green spaces, and a mobile health van—can lower cancer risk. Researchers will track 300 Black adults living in high-poverty areas to see if these changes reduce stress and encourage healthier…

This study tests whether giving antiviral medication to high-risk pregnant women and their newborns can prevent the baby from getting hepatitis B during birth. About 450 women and their infants in Africa will take part. The goal is to find a safe and effective way to stop the vir…

This study aimed to see if combining kangaroo mother care (continuous skin-to-skin contact) with a plastic bag could prevent dangerous low body temperature in preterm infants born between 32 and 36 weeks. The trial was withdrawn before any babies were enrolled, so no results are …

This study tests whether siltuximab can lessen the severity of cytokine release syndrome (CRS) and nerve-related side effects (ICANS) that often occur after CAR-T cell therapy for blood cancers like lymphoma, multiple myeloma, and leukemia. About 30 participants will receive silt…

This study was designed to see if a procedure called transarterial embolization is safe and possible for children aged 2-18 with incurable soft tissue sarcoma. The procedure involves blocking blood flow to tumors using tiny particles. The goal was to help control the disease and …

This study aimed to see if a general type of group therapy, using basic communication skills common to all therapies, could help adults with anxiety, depression, PTSD, or stress. The goal was to make treatment easier to deliver without needing special training for each condition.…

This study tests a program called UPHOLDS to help older adults with advanced heart failure feel better and improve their quality of life. 64 participants will try different combinations of support, like extra education sessions, financial coaching, and a one-time visit with a pal…

This study aimed to see if very low, non-hallucinogenic doses of psilocybin could reduce demoralization—feelings of hopelessness and meaninglessness—in adults. Researchers planned to give microdoses to 0 participants and measure changes in mood and thinking. However, the study wa…

This study was designed to see if a specific nerve block could reduce pain and opioid use after knee arthroscopy. It planned to enroll adults needing knee surgery, but was withdrawn before any participants joined. No results are available.

This study looks at whether elastic tape (KT tape) works better than a traditional arm sling for children with a broken collarbone. About 50 children will be randomly assigned to wear either tape or a sling, and researchers will track their pain, disability, and painkiller use. T…

This study was designed to see if giving sildenafil (a blood pressure medicine) to mothers during labor could reduce complications like fetal distress and birth asphyxia in low-resource areas. It planned to enroll pregnant women at term and compare sildenafil to a placebo. Howeve…

This study tested whether Bodewell eczema products can safely improve skin and quality of life in adults with atopic dermatitis (eczema). Fifteen participants used the topical products for 12 weeks. Researchers measured changes in skin severity and daily life impact.

This study tests a 6-month online program designed to help people with multiple sclerosis (MS) increase their physical activity. Researchers want to see if the program improves walking, thinking, fatigue, mood, and quality of life. About 280 adults with MS who are not very active…

This study tests whether using a blood flow restriction cuff during physical therapy helps elderly patients (65+) regain leg strength and muscle size after hip fracture surgery. Twenty participants will be followed to measure thigh circumference, muscle strength, pain, and mobili…

This study tests whether trained lay coaches (not doctors or nurses) can help family caregivers of people with advanced cancer feel less distressed and better supported. About 387 caregivers from underserved communities in the Southern U.S. will receive coaching sessions over the…

This study tests a 12-week coaching program called CuRB-IT for family caregivers of people with dementia. 266 caregivers are randomly assigned to start the program right away or after a delay. The goal is to see if the program reduces care-resistant behaviors and helps caregivers…

This study tests a patient-centered counseling method called motivational interviewing to help teenagers aged 14-19 improve their oral hygiene while wearing braces. Fifty participants will receive supportive, non-judgmental conversations about setting oral health goals, instead o…

This study tests a precise radiation treatment called Virtual Cone radiosurgery for people with severe trigeminal neuralgia—a condition causing intense facial pain. About 40 adults whose pain isn't controlled by medication will receive this frameless, non-invasive treatment. The …

This study tests whether three natural supplements—curcumin, resveratrol, and stinging nettle—can improve physical and mental health in veterans with Gulf War Illness. About 390 veterans from across the U.S. will take part online. The goal is to find safe, accessible treatments f…

This study looks at whether a plant-based omega-3 supplement from flaxseed can reduce pain and inflammation in children with sickle cell disease. About 30 kids aged 5–18 will take flaxseed and report pain levels and quality of life. The goal is to find a more acceptable alternati…

This study tests a new program where a health coach helps Black adults with advanced heart failure manage their pain. The goal is to see if the program is practical and acceptable to patients. Ten participants will try different combinations of pain management support, and resear…

This study looks at whether eating a better diet and cutting calories can improve physical function, thinking, pain, fatigue, mood, and anxiety in 100 adults with multiple sclerosis. Participants are overweight or obese and have relapsing-remitting or secondary progressive MS. Re…

This study compares two approaches to help stroke survivors with mild-to-moderate thinking problems. Both use a computer game to train how quickly the brain processes information. One group also practices everyday tasks and learns ways to use these skills at home, while the other…

This study planned to test whether a special type of PET/MRI scan could detect early signs that targeted therapy is working in people with stage IV HER2+ breast cancer. It was designed for adults aged 18 to 75 with HER2+ metastatic breast cancer. However, the study was withdrawn …

This study looks at whether regularly measuring body fat in very preterm infants (born at 28-32 weeks) can help them grow with less fat by 3 months of age. About 50 babies will take part, and researchers will use a special machine to check body composition. The goal is to see if …

This study uses a special radioactive tracer and PET/MRI scans to track white blood cells in the brain. Researchers want to see if these cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome, compared to healthy volunteers. The goal is…

This study looks at what happens when doctors do not give a second round of chemotherapy right away based on the results of a standard mid-treatment bone marrow biopsy in adults with newly diagnosed acute myeloid leukemia (AML). About 60 participants will receive usual first chem…

This study looks at how the brain changes and adapts when the central part of vision is lost, which happens in conditions like macular degeneration. Researchers will test healthy adults aged 18-30 with normal vision to understand these brain changes better. The goal is to use thi…

This study tests a training program called CASCADE for family caregivers of people with advanced cancer. The goal is to see which parts of the training best help caregivers support their loved one in making medical decisions. 256 caregivers will receive different combinations of …

This study follows 830 women in Alabama who are at risk for HIV and sexually transmitted infections (STIs). Researchers want to learn what factors affect their risk and how often they use PrEP, a medicine that prevents HIV. Participants will not receive any treatment but will pro…

This study explores whether taking antidepressants can lower inflammation in the gums of people who have both chronic gum disease and depression. Researchers will measure inflammatory markers in gum fluid and analyze plaque bacteria. The study involves 92 adults with moderate to …

This study uses a non-invasive breathing test called forced oscillometry to measure lung function in 600 newborns, including those born early or with lung conditions. The goal is to better understand how well their lungs work and how they respond to treatments. No new treatments …

This study looks at how sleep and your body's internal clock affect your blood pressure at night. Researchers will measure melatonin, body temperature, and blood pressure in 1,427 adults. No treatment is given—the goal is simply to understand these connections better.

This study looks at blood stem cells (called EPCs) in people with diabetes and healthy volunteers to understand why they may not work properly in diabetes. Researchers want to see if these cells can predict the development of diabetic retinopathy, an eye disease that can cause bl…

This study looks at how vision loss from glaucoma affects the ability of older adults to move around and go places. Researchers are tracking 88 participants with glaucoma to see how far they travel from home and if dim lighting makes it harder. The goal is to better understand th…

This study looks at how the kidneys change a substance called glycolate into oxalate, which can form kidney stones. Fifteen healthy adults will eat a special low-oxalate diet and receive a safe, labeled form of glycolate to track it. Researchers will measure oxalate in urine and …

This study was designed to look for early signs of lung blood pressure problems in adults after mitral valve surgery. Researchers planned to use blood tests and heart imaging to find hidden risks. However, the study was withdrawn before enrolling any participants.

This study looks at whether a stress management and relaxation program, delivered through video calls, is practical and helpful for breast cancer survivors living in high-need areas of Alabama. About 25 survivors will take part, and researchers will also gather feedback from comm…

This study looks at how exercise changes the gut microbiome in breast cancer survivors and whether those changes help reduce fatigue and other symptoms. About 126 women who have finished primary cancer treatment will take part. Researchers will measure gut bacteria from stool sam…

This study aimed to test a type of talk therapy called acceptance and commitment therapy (ACT) for men who engage in chemsex (using drugs during sex). It planned to enroll men aged 18-65 in Alabama who had done chemsex in the past six months. However, the study was withdrawn befo…

This study looks at how being obese might raise the amount of oxalate the body makes, which can lead to kidney stones. Researchers will give 40 adults (both obese and non-obese) a special low-oxalate diet and measure their urine oxalate levels. The goal is to better understand th…

This study looks at whether a new, organized way of routing stroke patients to hospitals can help more people with severe strokes get a life-saving clot-removal procedure. About 4,900 adults in Alabama with suspected severe stroke will be included. The approach uses a central com…

This study was designed to explore how tiny energy-producing parts of cells, called mitochondria, might lead to heart damage in people with sepsis. Researchers planned to compare blood samples from sepsis patients and healthy volunteers. However, the study was withdrawn before an…

This study looks at whether providing education materials helps relatives of people with Lynch syndrome decide about genetic counseling and testing. About 185 adult relatives will be randomly assigned to receive either a standard information letter or a letter plus a booklet. Res…

This lab study looks at two materials used in bone grafting: Platelet Rich Fibrin (PRF) and a commercial product called GEM21S. Researchers want to see how much growth factor (PDGF-BB) each releases when mixed with bone substitutes. The goal is to find the best combination for be…

This study uses advanced PET/MRI scans to see if a heart attack leads to inflammation in the brain. Researchers will compare 6 people who recently had a heart attack with a control group. The goal is to better understand how the heart and brain are connected, which could lead to …

This study aims to develop a new test called EDSPD that measures how well the sinuses work in people with chronic rhinosinusitis (CRS). Researchers will give a drug called ivacaftor to 30 adults with CRS who have had a recent gram-negative bacterial infection. The goal is to see …

This study looks at brain scans of 156 people experiencing their first episode of psychosis who have never taken antipsychotic medication. Researchers want to understand why some patients get better with treatment while others do not. By comparing brain structure, function, and c…

This study asks up to 30 adults with spinal cord injury about their exercise habits and what they'd want in a physical activity program. Through surveys and interviews, researchers aim to learn what helps people start and keep exercising. The goal is to design better exercise pro…

This study explores whether adding a wearable device (like a smartwatch) to a home symptom monitoring program helps cancer survivors better track their health. Researchers will check how many patients agree to use the wearable and how well they stick with it. The goal is to find …

This study looks at how obesity changes the way the body handles oxalate, a substance that can form kidney stones. Researchers will compare normal-weight and obese adults who have had calcium oxalate stones. Participants eat a controlled diet and provide urine samples to measure …

This study looks at two ways to help primary care clinics better screen and treat urinary incontinence (bladder control problems) in women Veterans. About 2,500 women Veterans will take part, using a mobile app and online resources. The goal is to find the best method to improve …

This study looks at whether older adults with prediabetes have slower brain energy use and thinking speed compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can temporarily improve brain function. Twenty veterans aged 60-75 will under…

This study looked at whether combining patient questionnaires, staff training, and telemedicine could help people with HIV get better care for mental health and substance use issues. It was designed for adults receiving HIV care at five clinics in Alabama. The study was withdrawn…

This study looks at whether a person's insurance status affects how well their epidural works during a C-section. Researchers will review records from 2,500 pregnant adults at one hospital. The goal is to find out if there are unfair differences in pain relief based on insurance …

This study compares a new, less invasive method (using a needle through the skin) with traditional surgery to create blood vessels for dialysis. The goal is to see if it's possible to run a larger trial that recruits and keeps enough patients. 21 adults who need a dialysis blood …

This study tests whether a telehealth program, called a Living Donor Navigator, can help more people with kidney disease find living donors. About 347 patients will be randomly assigned to receive the navigator service right away or after a delay. The goal is to see if remote sup…

This study was designed to use a special PET scan tracer to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of the neck arteries without symptoms). It planned to compare those with severe versus mild narrowing. However, the study was withd…

This study tests a new, tiny camera (micro OCT) that can take detailed pictures of the airways in the lungs and nose. Researchers want to see if it works well in adults with cystic fibrosis and healthy volunteers. The goal is to better understand early lung damage, which could le…