University Of Alabama At Birmingham

This early-stage study is testing a new combination of two drugs, loncastuximab tesirine and acalabrutinib, for people with chronic lymphocytic leukemia (CLL). The main goal is to find the safest and most effective dose of the loncastuximab drug when added to the standard acalabr…

This study is testing whether a newer, less invasive method to create a dialysis access point (called an endovascular fistula) works as well as traditional surgery. Researchers will randomly assign 80 adult patients needing dialysis access to receive either the surgical or the ne…

This study is testing whether a support program delivered by phone or video can help more people with kidney failure find a living donor. It compares a standard in-person program to a new telehealth version. The goal is to see if remote support makes it easier for patients to ask…

This is the first study in people to test a new oral pill called NTX-301. It aims to see if the drug is safe and can help control advanced forms of leukemia and related blood cancers that have come back or stopped responding to other treatments. The study will enroll about 22 adu…

This study aimed to test whether a specific type of talk therapy could help men reduce their use of drugs during sex (chemsex) and improve their mental health. It planned to compare the therapy to usual care. The trial was withdrawn before any participants were enrolled.

This study is testing whether delivering healthy meals to the homes of low-income Black pregnant women helps them eat better and manage their weight and blood pressure during pregnancy. Researchers will provide 10 meals per week to about 17 participants and compare their health o…

This study is testing whether adding extra protein to breast milk helps extremely premature babies gain more healthy, lean body weight and develop a healthier mix of gut bacteria. Researchers are comparing babies who get the protein-enriched milk to those who get standard breast …

This study is testing whether a supportive counseling method called motivational interviewing can help teenagers with braces take better care of their teeth and gums. About 50 teens aged 14-19 will have brief, encouraging conversations with dental professionals to help them set t…

This study is testing whether adding a pill called niraparib to the standard IV drug trastuzumab is safe and effective for people with advanced HER2-positive breast cancer that has spread. It's for patients whose cancer has grown despite previous HER2-targeted treatments. The mai…

This early-stage study is testing the safety of a new cell therapy for adults with a newly diagnosed, aggressive brain cancer called glioblastoma. Researchers are modifying a patient's own immune cells to resist chemotherapy, then injecting them directly into the brain alongside …

This study aimed to see if adding the diabetes medication acarbose to standard immunotherapy is safe and tolerable for people with advanced kidney cancer that has spread. Researchers wanted to check if this combination could help control the cancer better and see how it affects t…

This study aims to find the best method to control blood sugar in pregnant women with diabetes who need steroid shots to help their baby's lungs develop early due to risk of preterm birth. Researchers are comparing three different insulin management strategies over 5 days to see …

This study is testing whether a line of over-the-counter skincare products called Bodewell can help control eczema symptoms. Fifteen adults with moderate eczema will use the products for 12 weeks. Researchers will measure how much their skin improves and if their quality of life …

This small pilot study is testing if a simple telehealth program can help people better manage their high blood pressure after a trip to the emergency room. The program involves checking blood pressure at home and having weekly phone check-ins with a pharmacist to adjust medicati…

This trial tests combination therapies with the oral drug iberdomide for patients with multiple myeloma who still have tiny amounts of cancer detectable after a stem cell transplant. The goal is to use these drug combinations to eliminate these remaining cancer cells and achieve …

This study aims to improve access to non-surgical treatment for urinary incontinence (bladder leaks) for women veterans in the southeastern U.S. It compares two remote care models that provide primary care clinics with toolkits, mobile app training, and support. The goal is to se…

This study aims to find out if giving patients a specific, standardized dose of immune cells (called CD3+ T cells) during a stem cell transplant from a matched sibling leads to better and more predictable results. Researchers will give 20 adult patients a carefully measured dose …

This study aimed to improve care for people living with HIV who also struggle with mental health or substance use issues. It planned to use patient questionnaires, train clinic staff, and offer telemedicine appointments to make it easier for patients to get the help they need. Th…

This study aimed to see if giving sildenafil citrate (the medicine in Viagra) to mothers during labor could help babies get more oxygen, reducing the need for emergency C-sections, breathing assistance at birth, and infant deaths. It was a small pilot trial planned for pregnant w…

This early-stage study tested whether a minimally invasive procedure could safely be used to control advanced pediatric soft tissue sarcomas. It aimed to block the blood supply to tumors in children and young adults (ages 2-18) whose cancers had not responded to standard treatmen…

This study compares two different surgical methods for treating receding gums. It tests a newer, simpler technique (SAMRI) against a more established tunnel method. The goal is to see which one better covers exposed tooth roots, improves gum health, and causes less pain and swell…

This study planned to see if adding a daily pill called vibegron to standard Botox injections in the bladder works better for women with overactive bladder that hasn't improved with other treatments. Participants would have been randomly assigned to receive either the real pill o…

This study is testing if a specific weight loss program can reduce the body's production of a chemical called oxalate, which is a main component of many kidney stones. It involves obese adults who have previously formed calcium oxalate stones. Participants follow a strict, low-ox…

This small pilot study is testing whether baricitinib, a medication used for rheumatoid arthritis, is safe and effective for treating frontal fibrosing alopecia (FFA). FFA is a condition that causes permanent, scarring hair loss at the front of the scalp and eyebrows. The study w…

This study is testing whether adding extra nutrients to breast milk earlier (between days 4-7) helps very premature babies grow better than adding them later (days 10-14). Researchers will enroll 80 very preterm infants to see if early fortification leads to better body compositi…

This early-stage study is testing a modified herpes virus (M032) designed to infect and kill brain tumor cells while boosting the immune system. The trial aims to find the safest dose for 29 adults with recurrent glioblastoma or similar aggressive brain cancers who have few treat…

This study is testing if changing *when* you eat and *when* you get bright light can help control blood sugar in people with type 2 diabetes. About 344 adults will try either eating earlier in the day, using timed light therapy, both, or neither for 16 weeks. Researchers will mea…

This small study is checking if a 6-week, high-intensity exercise program using virtual reality (VR) headsets at home is practical and acceptable for young people with cerebral palsy. It will measure if the VR workouts can improve heart health, body composition, and blood markers…

This small, early-stage study is exploring whether taking a daily probiotic supplement for 12 weeks can help improve asthma control and reduce insulin resistance in obese adults who have both conditions. Researchers will measure changes in gut and airway bacteria, body weight, in…

This pilot study aimed to test whether giving sildenafil citrate (the active ingredient in Viagra) to mothers during labor could reduce fetal distress and birth complications in hospitals with limited resources. Researchers planned to compare sildenafil against a placebo pill in …

This study is testing a new statewide system to improve emergency care for the most severe strokes. It aims to get patients who need a specialized clot-removal procedure to the right hospital faster by coordinating ambulance crews and hospital resources through a central communic…

This study tests whether providing educational materials and care coordination help in emergency departments can improve how people with gout manage their condition. Researchers are enrolling 200 adults with gout to see if this approach helps them get better follow-up care after …

This study is testing whether delivering healthy meals to pregnant women who are overweight or have obesity can help them manage their weight gain during pregnancy. Researchers are working with 35 women to see if this approach is practical, acceptable, and shows early signs of be…

This study aimed to see if a new combination of PET and MRI scans could detect how well treatment is working in patients with advanced HER2-positive breast cancer earlier than current methods. The plan was to scan patients up to three times during their treatment to look for chan…

This study is testing whether a low daily dose of the drug tamoxifen can help prevent breast cancer in women who had radiation therapy to their chest area earlier in life. It involved 84 women who were randomly assigned to take either the low-dose tamoxifen or a placebo pill for …

This study is testing a new way to increase HPV vaccination rates in a rural Alabama county. High school students are creating and running a communication campaign to encourage their peers and community to get the HPV vaccine, which prevents several cancers. The goal is to see if…

This study tested whether placing preterm or low birth weight newborns in plastic bags during their first hour after birth helps prevent hypothermia (dangerously low body temperature). Researchers compared standard warming care alone to standard care plus a plastic bag covering t…

This study is testing whether improving neighborhood conditions—like adding sidewalks, parks, lighting, and community events—can help reduce cancer risk in high-poverty areas. Researchers are working with 300 Black residents from specific low-income neighborhoods to see if these …

This large Phase 3 trial tests whether giving antiviral medication to pregnant women with hepatitis B and their newborns can prevent the virus from passing to the baby during birth. The study involves 450 women in Africa and compares starting medication earlier in pregnancy versu…

This study tests whether church-based health coaching can help prevent high blood pressure in rural Black adults in Alabama. Participants with slightly elevated blood pressure receive education, tablets for online cooking and exercise classes, and some get additional phone coachi…

This study is testing whether a simple educational program can prevent pregnant women from catching cytomegalovirus (CMV), a common virus that can cause serious health problems for unborn babies. The program teaches women how to reduce their risk of infection through hygiene and …

This study aimed to see if a simple, low-cost method could prevent dangerously low body temperature in premature babies. It planned to test whether combining skin-to-skin 'kangaroo mother care' with placing the baby in a plastic bag was better than skin-to-skin care alone. The tr…

This early-stage study aimed to test whether very small, non-hallucinogenic doses of psilocybin (a compound from 'magic mushrooms') could help reduce feelings of hopelessness and meaninglessness in adults. The study planned to give participants weekly doses for five weeks while m…

This study is testing a new support program called UPHOLDS for older adults with worsening heart failure. The program uses trained coaches to provide education, help manage symptoms, and offer financial advice to improve quality of life. Researchers are testing different parts of…

This study is testing if adding a special therapy called blood flow restriction (BFR) to standard physical therapy can help older adults recover faster after hip fracture surgery. BFR involves using a cuff to briefly reduce blood flow to the leg during light exercises, which may …

This study is testing two different training programs for adults who have had a stroke and are still experiencing mild-to-moderate problems with memory, attention, or thinking speed. Both programs use a web-based computer 'game' designed to improve how quickly the brain processes…

This study is testing a non-surgical radiation treatment for people with severe, medication-resistant hand tremor from Parkinson's disease or Essential Tremor. It is for patients who are not good candidates for or do not want deep brain stimulation surgery. The treatment uses pre…

This study is testing whether three natural supplements—curcumin, resveratrol, and stinging nettle—can help improve symptoms and quality of life for veterans with Gulf War Illness. The trial involves 390 participants who served in the 1990-1991 Gulf War and meet specific illness …

This study is testing a new, frameless type of radiation therapy for people with severe trigeminal neuralgia, a debilitating facial nerve pain. It aims to see if this 'Virtual Cone' radiosurgery is practical to perform and if it provides pain relief. The research will also track …

This study aimed to test if a general form of talk therapy, using common communication skills, could help adults with various mental health concerns like depression and anxiety. It planned to compare this approach to more specific, specialized therapies. The trial was withdrawn b…

This study is testing whether a drug called siltuximab can help control two serious side effects that sometimes occur after CAR-T cell therapy for blood cancers. CAR-T therapy can cause dangerous immune overreactions called cytokine release syndrome (CRS) and neurological problem…

This study is testing a 6-month online coaching program designed to help people with multiple sclerosis (MS) become more physically active. Researchers want to see if this program can help participants move more, which may improve their walking, thinking, fatigue, mood, and overa…

This study is testing whether a video-conferenced stress management and relaxation training program is practical and acceptable for breast cancer survivors in Alabama. The program aims to improve health and wellbeing by teaching stress reduction techniques. Researchers are specif…

This study is testing whether adding flaxseed, a plant-based source of omega-3 fatty acids, to the diet can help reduce pain and inflammation in children with sickle cell disease. Researchers will enroll 30 children, aged 5 to 18, to see if a flaxseed-rich diet is more acceptable…

This study is testing a training program called CASCADE for family members who help make medical decisions for a loved one with newly diagnosed advanced cancer. The program uses nurse coaches to teach communication and decision-support skills over phone calls. Researchers want to…

This study aimed to test if a specific nerve block and numbing shots at the incision sites could better control pain after a common knee surgery (arthroscopy). It planned to compare pain levels, medication use, and sleep quality in patients receiving these methods. The trial was …

This study is testing a coaching program designed to support family members and friends who care for people with advanced cancer. The program uses trained lay coaches to provide guidance on managing stress, getting help, and making decisions over several months. Researchers want …

This study is testing a new phone-based support program designed to help Black adults with advanced heart failure manage their pain. A trained coach will guide participants through different combinations of support techniques, like education, relaxation, and coping skills. The go…

This study aims to understand how the brain adapts when people lose their central vision, as happens in conditions like macular degeneration. Researchers will work with healthy young adults, using special displays to temporarily simulate vision loss and training exercises to see …

This study aims to understand how much of a natural body chemical called glycolate gets turned into oxalate, which is a main ingredient in kidney stones. Researchers will give 15 healthy adults a special tracked form of glycolate while they follow a low-oxalate diet. By measuring…

This study aims to understand why some women in Alabama get sexually transmitted infections (STIs) or HIV, and what influences their use of prevention medications. Researchers will follow 830 women who identify as cisgender or transgender and are at risk for HIV, using a smartpho…

This pilot study tests whether giving doctors information about a premature baby's body fat levels helps reduce the baby's total body fat by 3 months old. It involves 50 very premature infants. Half the babies' doctors will see the body fat data, while the other half's doctors wi…

This study aims to understand how a 10-week exercise program might change the types of bacteria living in the gut of breast cancer survivors. Researchers will carefully control participants' diets and measure if changes in gut bacteria are linked to improvements in fatigue and ot…

This study aimed to understand if people with blocked neck arteries (carotid stenosis) but no symptoms have hidden brain inflammation. Researchers planned to use a special PET scan to measure this inflammation in two groups: those with severe blockages and those with mild blockag…

This study aims to understand if and how white blood cells enter the brain in conditions like fibromyalgia, chronic fatigue syndrome, and multiple sclerosis. Researchers will use a special radioactive tracer and PET/MRI scans to track these cells in 120 participants, including he…

This study uses repeated brain scans to understand why standard antipsychotic medications don't work well for many people experiencing their first episode of psychosis. Researchers will follow 156 young adults who have never taken these medications, scanning their brains four tim…

This study is testing a new, non-invasive device to measure lung function in newborn babies. It aims to see how well the device works for both healthy babies and those born with breathing problems, like premature infants. The goal is to gather information to better understand inf…

This study aims to understand how sleep habits and your body's natural daily rhythm affect blood pressure during the night. Researchers will observe over 1,400 people and, for a smaller group, conduct a special 30-hour test to measure their internal body clock. The goal is to gat…

This study is testing whether educational materials help relatives of people with Lynch syndrome decide about getting genetic counseling and testing. About 185 relatives at risk will receive either a standard information letter or the letter plus an educational booklet. Researche…

This study aims to understand why diabetes damages the eyes. Researchers are comparing special blood cells from diabetic patients and healthy people to see if the cells' function can predict the development of diabetic retinopathy, a serious eye disease. The goal is to gather kno…

This is a lab study, not a treatment trial. Researchers are testing two materials used to help bone regrow after dental surgery. They want to see how much of a key healing protein each material releases over time. The goal is to gather information to help dentists choose the best…

This study aims to understand why people with obesity might be more prone to forming calcium oxalate kidney stones. Researchers are comparing how people with a normal weight and people with obesity process a natural substance called oxalate, which is a key component of these ston…

This study aims to find out what kind of exercise program people with spinal cord injury would prefer to use and stick with. Researchers will interview 30 adults with spinal cord injury to understand their needs and then create a survey based on their feedback. The goal is to gat…

This study aims to understand why people with obesity have a higher risk of developing kidney stones. Researchers will put 40 healthy adults without a history of stones on a special low-oxalate diet to measure how much oxalate their bodies produce internally. The goal is to gathe…

This study aimed to understand how heart valve surgery affects lung blood pressure. Researchers planned to check blood samples and heart ultrasounds from patients before and after their procedures. The goal was to find early warning signs of a dangerous lung condition that can de…

This study aims to understand how glaucoma affects the daily mobility of older adults. Researchers are looking at whether vision loss from glaucoma makes it harder for people to leave their homes and move around their communities, especially in low-light conditions like at night.…

This study aims to understand the link between depression and gum disease. Researchers are checking if taking antidepressants can reduce inflammation in the gums of people with chronic periodontitis. They enrolled 92 adults who already needed gum surgery to compare samples from t…

This study aimed to understand why sepsis, a severe body-wide infection, often damages the heart. Researchers planned to measure tiny energy-producing parts of cells (mitochondria) and markers of inflammation in the blood of sepsis patients. The goal was to see if these measureme…

This study uses special brain scans to check for inflammation in the brain after a person has a heart attack. Researchers want to see if the body-wide inflammation from a heart attack also affects the brain. The findings could help doctors understand the link between heart and br…

This study is testing a new, high-resolution imaging tool to take detailed pictures inside the lungs and nose. The goal is to better understand diseases like cystic fibrosis, COPD, and COVID-19, which could help guide future treatments. Researchers are enrolling 60 adults and tee…