Tiny lab test hopes to improve bone grafting for tooth loss
NCT ID NCT04964466
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This lab study compares how much growth factor (PDGF-BB) is released over time from two materials used in bone grafting: platelet-rich fibrin (PRF) from a patient's blood and a commercial product called GEM21S. Researchers will mix these with bone substitutes and measure growth factor levels at several time points. Only 5 samples are being tested, so this is early-stage knowledge gathering, not a treatment trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Platelet-rich fibrin (PRF) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB, GEM21S)
What this could lead to
If successful, this could help dentists choose the best way to deliver growth factors for bone healing procedures.
What could go wrong
This is a very small lab experiment with only 5 samples, not a patient trial. Results may not translate to real-world healing.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 35294-0007, United States