Face mask zaps nerve pain: new hope for trigeminal neuralgia?

NCT ID NCT02708810

Ongoing Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a precise radiation treatment for trigeminal neuralgia, a condition that causes severe facial pain. Instead of a metal frame screwed into the skull, a special face mask holds the head still while x-rays target the painful nerve. The trial includes 40 adults whose pain isn't controlled by medication. Researchers want to see if this frameless approach is feasible and how well it relieves pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Virtual cone radiosurgery device (frameless face mask)
What this could lead to: If it works, this could offer a non-invasive, precise treatment option for people with severe facial nerve pain that isn't helped by medication.
What could go wrong: This is a small, early-phase trial with only 40 people at one hospital. The device may not relieve pain for everyone, and there are risks of nerve damage or other side effects.

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Conditions

The condition(s) this trial relates to.

trigeminal neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRIGEMINAL NEURALGIA

Contacts and locations

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Locations

Hazelrig-Salter Radiation Oncology Center

Birmingham, Alabama, 35233, United States

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