New drug may tame Life-Threatening side effects of cancer immunotherapy
NCT ID NCT04975555
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether the drug siltuximab can lessen the severity of cytokine release syndrome (CRS) and neurological side effects (ICANS) that often occur after CAR-T cell therapy for blood cancers like lymphoma and leukemia. Twenty-four participants received siltuximab alongside their CAR-T treatment. The goal was to see if the drug could help resolve these side effects faster, making the therapy safer and more tolerable.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States