Could a fixed T-Cell dose make stem cell transplants safer?
NCT ID NCT00959140
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving a fixed number of CD3+ T cells (a type of immune cell) during stem cell transplants from sibling donors leads to more predictable outcomes. Researchers want to see if standardizing the dose reduces variation in complications like graft-versus-host disease. The trial involves 20 patients aged 19 and older.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CD3+ T cell depletion (device-based cell selection)
What this could lead to
If successful, this could make stem cell transplants more predictable and reduce complications like graft-versus-host disease.
What could go wrong
This is a small, early-phase study with only 20 participants, so results may not apply broadly. The procedure carries risks including infection and graft failure.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Alabama Hospital
Birmingham, Alabama, 35294, United States