Could a common antibiotic help kids breathe easier with severe RSV?

NCT ID NCT05026749

Recruiting now Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the antibiotic azithromycin can help children with severe RSV infection who need breathing support in the ICU. About 370 children will receive either azithromycin or a placebo for three days. The main goal is to see if the drug shortens the time they need to stay in the hospital.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: azithromycin
What this could lead to: If it works, this could provide a simple, widely available treatment to shorten hospital stays for children with severe RSV.
What could go wrong: This is a single drug tested in one setting; results may not apply to all children, and azithromycin may not improve outcomes or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

respiratory syncytial virus infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY SYNCYTIAL VIRUS INFECTIONS

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's National Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Oklahoma Health Sciences
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Rainbow Babies and Children's Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
Riley Children's Health
RECRUITING

Indianapolis, Indiana, 46202, United States
St. Louis Children's Hospital
RECRUITING

St Louis, Missouri, 63110, United States
The University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
The University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75247, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06520-8064, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.