COGNITIVE IMPAIRMENT

This large study is testing whether aiming for a lower blood pressure target can better protect people with diabetes from serious heart problems and memory decline. It involves nearly 9,500 participants who have type 2 diabetes and are at high risk for heart disease. Participants…

This study is testing whether a daily treatment using special light and sound stimulation can slow the progression of Alzheimer's disease. About 670 people with mild to moderate Alzheimer's will use either the active stimulation device or a look-alike sham device at home for a ye…

This study is testing whether a one-year course of a dietary supplement called spermidine can help older adults with heart disease. Spermidine is a natural compound found in foods like whole grains and nuts. Researchers will check if it improves heart function, muscle mass, physi…

This study is trying to find out if clearing a severely blocked neck artery can reverse memory and thinking problems in people who have no other stroke symptoms. It is enrolling 385 people from a larger stroke prevention trial who have both the artery blockage and signs of reduce…

This study is testing whether a 6-month program teaching memory strategies and healthy lifestyle habits can help older adults who are worried about their memory. Participants are randomly placed into one of two groups: one receives general coaching, while the other gets specific …

This study is testing whether a program of brain-training computer games and guided physical exercise, done before and after major surgery, can help older adults protect their thinking skills and ability to live independently. Researchers are comparing this combined program to si…

This study is testing a new automated screening tool designed to help primary care doctors quickly identify early signs of memory or thinking problems in older adults. The tool combines simple tasks like symbol matching and voice exercises to create a risk score. Researchers are …

This study aimed to test if a new, short questionnaire could help primary care doctors better identify patients with early memory or thinking problems during their annual check-up. The goal was to see if using this simple 4-question screener would lead doctors to order more appro…

This study is testing whether adding simple mental tasks to a walking routine is more helpful than walking alone for older adults experiencing 'brain fog'—feelings of mental cloudiness or poor concentration. About 90 participants aged 65+ will be randomly assigned to either walk …

This study is testing a new home exercise program for older adults with mild memory loss or dementia. Participants use a special video game system at home to do balance and thinking exercises, which are supervised remotely by a therapist through video calls. The goal is to see if…

This study is testing whether a fun, group-based program can help older adults with mild thinking or physical challenges. The program combines guided art-making and exercise video games. Researchers want to see if it improves memory, attention, balance, and walking ability, and i…

This study is testing a new remote therapy program designed to help reduce anxiety in people living with mild cognitive impairment or dementia. The program uses video calls and a special software platform to deliver cognitive behavioral therapy techniques. Researchers are measuri…

This study is testing whether digital brain games (on a device) or physical, hands-on puzzles and activities are better at helping older adults with mild to moderate Alzheimer's disease. It involves over 500 participants in Portugal and aims to see which type of activity best sup…

This study is testing whether doing computerized brain training exercises in the morning or late afternoon works better for older adults recovering from a stay in the intensive care unit (ICU). Researchers want to see if the timing of these exercises can help improve thinking ski…

This study aims to better predict how deep brain stimulation (DBS) surgery for Parkinson's disease might affect a patient's thinking and memory. Researchers will follow 30 Parkinson's patients before and for five years after their DBS surgery, collecting various health data to id…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This study is testing a new research PET scanner called the PennPET Explorer. The goal is to see how well this scanner works, as it can image a much larger section of the body at one time than standard scanners. The study involves adults, including some with cognitive impairment,…

This study aims to learn which personal factors predict a person's success in group therapy for alcohol use disorder. Researchers will follow 120 patients through treatment and for up to three years afterward to see if factors like other mental health conditions, personality trai…

This study is testing whether taking music improvisation classes can help improve thinking skills and self-control in older adults. Researchers want to see if this fun, creative training can help people stay mentally engaged, especially those with mild memory concerns. The study …

This study aims to understand why many people develop long-term thinking and memory problems after surviving a serious injury and ICU stay. Researchers are following 432 trauma patients to see how factors like confusion in the hospital (delirium) and body-wide inflammation affect…

This study aims to understand why many intensive care unit (ICU) patients develop severe, long-lasting muscle weakness. Researchers will examine 50 critically ill patients using muscle ultrasounds, blood tests, and small muscle samples to learn how this weakness develops. The goa…

This study aims to understand how often and why patients experience memory and thinking problems after hip or knee replacement surgery. Researchers are following 505 patients aged 50+ to track their cognitive function before and after surgery for several months. The goal is to id…

This study aims to understand if being physically active while in the hospital helps older adults recover better after a life-threatening illness. Researchers are tracking 312 patients with conditions like sepsis to see how their activity levels relate to their physical and menta…

This study aims to understand if and how an irregular heartbeat (atrial fibrillation) causes short-term changes in thinking, memory, and decision-making. Researchers will compare how 600 patients perform on tablet-based thinking tests while their heart rhythm is irregular versus …

This study aims to understand the genetic causes of severe childhood obesity and related conditions like Bardet-Biedl Syndrome. Researchers will analyze genetic information from 1,000 children and adults in Germany who developed severe obesity early in life. The goal is to identi…