COGNITIVE IMPAIRMENT

This study tests whether a tablet-based brain training program and/or a powerful cholesterol-lowering drug (PCSK9 inhibitor) can improve thinking and memory in 420 adults aged 55-80 with narrowed brain arteries. Participants will be split into four groups, combining or not combin…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study tests whether eating foods high in resistant starch (a type of fiber) can slow down memory and thinking problems in people who have a high genetic risk for cognitive decline. Seventy adults aged 40 and older with obesity or large waistlines will eat either high-resista…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study tests a 6-week virtual rehabilitation program to help prevent falls in older veterans who have cognitive impairment (memory or thinking problems). Falls are a major cause of injury and hospital stays for this group. The program is delivered remotely via video calls and…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive flexibility—the ability to adapt thinking—in people with major depression. 105 participants will receive either active stimulation to two brain areas, active stimulation to one a…

This study tests whether a handheld robot that guides meditation with touch and voice can improve sleep quality in older adults with mild memory concerns. 100 participants will either use the robot or a standard meditation app for daily sessions. The goal is to see if the robot h…

This study explores whether a virtual reality mindfulness meditation program is practical and well-liked by older adults with mild to moderate cognitive impairment living in long-term care homes. About 36 participants will try up to 8 VR sessions over 4 weeks, and researchers wil…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether minocycline, an antibiotic that reduces brain inflammation, can safely prevent or reverse memory and thinking problems in adults with sickle cell disease. About 30 participants will take either a low dose, high dose, or placebo for one year. Researchers w…

This study tests whether a new medicine, Xanomeline/Trospium (also called KarXT), can improve thinking and memory in adults with schizophrenia. Unlike standard antipsychotics, this drug targets a different brain system and may help with cognitive symptoms. Researchers will follow…

This study tests a 10-session program called ViCCY for caregivers of heart failure patients who also have mild to moderate memory problems. About 256 caregivers and 60 patients will take part. The goal is to see if the program improves caregivers' mental health and reduces stress…

This study tests whether N-Acetyl-Cysteine (NAC), a supplement, can reduce chemotherapy-related cognitive impairment (often called 'chemo brain') in ovarian cancer patients. About 102 postmenopausal women with advanced ovarian cancer receiving platinum-based chemotherapy will tak…

This pilot study will test whether a non-invasive brain stimulation device called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory problems. Eighty participants will receive six sessions of targeted magnetic pulses over three weeks. Researc…

This study tests whether giving home health aides extra training on dementia care can reduce troubling behaviors in older adults with dementia or mild cognitive impairment and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs …

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory and thinking in people with bipolar disorder. The trial will involve 88 adults with bipolar disorder who are currently stable. They will receive e…

This study tests whether aerobic exercise, alone or with a gentle brain stimulation technique called tDCS, can improve thinking and memory in people with treatment-resistant schizophrenia. About 160 participants will be assigned to exercise, tDCS plus exercise, or a control group…

This study looks at whether whole body vibration therapy—standing on a gently vibrating platform for 25 minutes, three times a week—can improve thinking, balance, and quality of life in older adults with mild cognitive impairment. Researchers will compare the vibration group to a…

This study looks at how obstructive sleep apnea (OSA) affects thinking skills like attention and memory, and how those changes relate to quality of life. Adults newly diagnosed with OSA will take an overnight sleep test, followed by computer tasks and questionnaires. Their result…

Some people have memory, attention, or thinking speed issues after leaving the ICU. This study explores whether a simple eye-tracking test can help identify these problems early. Adult patients who recently left the ICU will take a cognitive test and an eye-tracking test. The goa…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention. Researchers will test 40 adults—some who use cannabis often and some who use it rarely—to see if eye-tracking can reliably detect impairment. The goal is to deve…

This study looks at why some older people experience confusion or memory problems after major surgery. Researchers will test 40 patients aged 70 and older before and after colorectal or urological surgery. They will use memory tests and blood samples to see if they can link chang…

This study tests whether a device that briefly restricts blood flow to the arm (remote ischemic conditioning) can improve thinking and memory in people with cerebral small vessel disease. Forty participants will receive either the real treatment or a sham version twice daily for …

This study looks at whether older adults with mild memory issues are more likely to become confused after planned hip replacement surgery. Researchers will test memory before surgery and watch for confusion in the first three days after. The goal is to see if a quick memory test …

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study looks at how diabetes affects small blood vessels and nerves in the eyes and brain. Researchers will use advanced imaging to detect damage and test a traditional Chinese herbal medicine called Tangshen'an Granules to see if it can help. 160 adults with diabetes will ta…