COGNITIVE IMPAIRMENT

This study tests whether eating foods with resistant starch (a type of fiber) can slow down memory loss in people at high genetic risk for cognitive decline. About 70 adults aged 40 and older will either eat high-starch foods or regular starch foods daily. Researchers will track …

This study tests whether a non-invasive treatment called remote ischemic conditioning (using a blood pressure cuff on the arm) can help prevent or treat memory and thinking problems in people with cerebral small vessel disease. Forty adults aged 30-80 with mild cognitive impairme…

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study aims to see if a non-invasive brain stimulation technique (rTMS) and computer-based thinking exercises can improve mental flexibility in adults with major depression. Researchers will use brain scans to target specific areas thought to be involved in this thinking prob…

This study will see if an artificial intelligence (AI) tool can analyze speech recordings to help identify people with memory problems who need a specialist dementia evaluation. Researchers will record 440 adults over 50 doing speaking tasks and cognitive tests. The goal is to de…

This study tests a 6-week virtual rehabilitation program to help prevent falls in older veterans who have memory or thinking problems. Falls are a major cause of injury and hospitalization in this group. The program will be delivered remotely, and researchers will measure how wel…

This study tests whether a supplement called N-Acetyl-Cysteine (NAC) can reduce memory and thinking problems caused by chemotherapy in ovarian cancer patients. About 102 women with advanced ovarian cancer will receive NAC alongside their standard platinum-based chemo. The goal is…

This study tests whether giving home health aides extra training on dementia care can help reduce troubling behaviors in older adults with dementia or mild cognitive impairment. It also looks at whether this training improves quality of life for both the patients and their care p…

This study tests whether aerobic exercise, alone or with a gentle brain stimulation technique called tDCS, can improve memory and attention in people with treatment-resistant schizophrenia. About 160 adults will take part in a 6-week program. The goal is to find a safe, drug-free…

This study tests a 10-session program called ViCCY for informal caregivers (spouses or children) of older adults with heart failure and mild to moderate memory problems who are receiving home health care. The goal is to reduce caregiver stress and improve their mental health. Abo…

This study tests whether minocycline, an antibiotic that reduces brain inflammation, can safely prevent or reverse memory and thinking problems in adults with sickle cell disease. About 30 participants will receive either a low dose, high dose, or placebo for one year. Researcher…

This study tests whether standing on a gently vibrating platform for 25 minutes, three times a week, can improve thinking, balance, and quality of life in older adults with mild cognitive impairment. 180 volunteers aged 60 and older will be randomly assigned to vibration, a place…

This study tests whether a handheld robot that vibrates and talks can help older adults with mild memory problems sleep better. 100 participants will either use the robot or a standard meditation app for several weeks. The goal is to see if the robot's touch and breathing cues ma…

This study tests a noninvasive magnetic stimulation technique (TMS) targeting brain areas linked to memory and vision. 88 adults with bipolar disorder in a stable phase will receive either real or sham stimulation over 5 days. The goal is to see if this approach safely improves c…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve memory and thinking in people aged 50 to 90 with mild to moderate cognitive decline. Eighty participants will receive six sessions of rTMS over three weeks. Researchers will measure change…

This study tests whether a special type of bright light therapy can improve thinking and memory problems in people with major depression. About 120 adults with depression and cognitive issues will either receive the special light or a dim red placebo light for four weeks. Researc…

This study compares two brain training programs for adults with long-lasting brain fog after a viral infection, including from COVID-19 or ME/CFS. About 30 participants will do online games and a gentle nerve stimulation over 2-4 weeks, with follow-ups for 6 months. The goal is t…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention in people who use cannabis often versus rarely. Researchers will give 40 healthy adults either a placebo, a low dose, or a high dose of THC and test their eye con…

This study looks at whether a detailed health check called a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can help older adults (60+) with advanced kidney disease get a fairer evaluation for a kidney transplant. About 50 participants will either receive …

This study explores whether advanced eye and brain imaging can detect early damage to nerves and blood vessels caused by diabetes. Researchers will also test a Chinese herbal medicine, Tangshen'an Granule, to see if it can prevent or treat this damage. About 160 adults with diabe…

This study looks at why some older adults experience confusion or memory problems after major surgery. Researchers will test memory and collect blood samples from 40 patients aged 70 and older before and after colorectal or urological surgery. The goal is to see if these research…

This study looks at whether older adults with mild thinking or memory problems are more likely to become confused after planned hip replacement surgery. About 400 people aged 65 and older will take a short thinking test before surgery and be checked for confusion for three days a…