COGNITIVE IMPAIRMENT

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tested whether a 40-hour, 8-week cognitive telerehabilitation program could reduce the risk of memory and thinking problems after a stroke. 86 adults who recently had a stroke were randomly assigned to either the home-based brain training or standard care. The program …

This study tested if transplanting healthy gut bacteria (fecal microbiota) can help people with chronic insomnia. 80 adults received either the bacteria or a placebo in capsules. Researchers measured sleep quality using sleep tests and questionnaires to see if the treatment impro…

This study tested a 12-week intensive exercise program (aerobic and resistance training) in 58 adults aged 40-85 with type 2 diabetes and mild cognitive issues. The goal was to see if exercise could improve thinking, blood sugar, inflammation, and physical function. Results may h…

This study tested an experimental drug called EG-501 for people with lupus who experience cognitive impairment, often called "brain fog." The trial involved 131 participants who received either the drug or a placebo over 14 weeks. The goal was to see if EG-501 could safely improv…

This study tested whether a nasal insulin spray and a diabetes pill called empagliflozin, alone or together, could improve memory and brain function in 47 adults aged 55-85 with mild cognitive impairment or early Alzheimer's disease. The goal was to see if these treatments are sa…

This study tested a tablet-based platform called Tenèpsia® for remote cognitive assessments in 250 healthy adults and people with cognitive impairment. The goal was to collect normal test scores and validate the digital tool for diagnosing neurocognitive disorders. If proven reli…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested whether hypnotic suggestion can improve working memory in adults who had a brain injury at least a year earlier. 90 participants received either four weekly sessions of hypnosis or mindfulness. The goal was to see if hypnosis could unlock hidden memory capacity …

This study tested a 12-week music therapy program for 76 care home residents with dementia or cognitive impairment. Residents received individual music therapy sessions, and staff were trained to use music techniques. The goal was to see if music therapy could reduce unmet care n…

This study tested a personalized brain stimulation technique called iTBS to help people with long-term thinking and memory problems after a stroke. Sixty participants received either real or sham stimulation over three weeks. The goal was to see if this approach could safely impr…

This study tested whether combining somatotherapy (body awareness and movement exercises) with occupational therapy (training in daily tasks like dressing and cooking) could improve cognitive function in 50 adults who had a stroke. Participants received 35-minute sessions five da…

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study tested whether a humanoid robot named HUMANE could help older adults living at home feel less lonely and more connected. Sixty people aged 50 and older used the robot for 6 weeks, interacting with it through music, news, games, and conversation. Researchers measured lo…

This study tested a 7-week program to help older adults with both chronic pain and mild memory problems manage their pain better. Participants received weekly phone coaching and watched educational videos. The goal was to see if the program was practical and could reduce how much…

This study tested whether virtual music therapy can lower stress as well as live music therapy in older adults with memory problems. Thirty-two participants from assisted living facilities took part. Researchers measured stress through surveys, heart rate, and blood pressure befo…

This study tested whether a program of aerobic, strength, and balance exercises, combined with a gentle vibrating device placed on the legs, could help older adults in care homes who have muscle loss (sarcopenia) and frailty. Forty adults over age 75 took part. The goal was to se…

This study tested whether walking while doing simple mental tasks (like memory or attention exercises) can help older adults with brain fog. 90 people aged 65+ took part, either walking with cognitive tasks or walking only, three times a week for four weeks. Researchers measured …

This study tested whether giving insulin through the nose can help people with mild memory problems. Thirteen participants received either 20 or 40 units of insulin via a nasal device. Researchers measured how much insulin reached the fluid around the brain and checked memory wit…

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinkin…

This study tested an optimized multichannel tDCS (a non-invasive brain stimulation device) against standard and sham versions in 60 adults with moderate-to-severe major depression. The goal was to see if the new protocol better reduces depressive symptoms and improves memory and …

This study tested whether two types of mild electrical brain stimulation (tDCS and tRNS) could improve memory and thinking in 36 people with schizophrenia. Participants received both types of stimulation on different days to compare effects. The goal was to see if these safe, non…

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested a hearing care program for older adults with both hearing loss and dementia. Speech-language pathologists delivered the program at home. The goal was to see if better hearing could reduce troubling symptoms like agitation and improve quality of life. 77 people t…

This study tested whether giving intravenous guanfacine to critically ill patients with delirium in the ICU could improve their brain function. 46 adults on breathing machines or for shock were randomly assigned to receive guanfacine or a placebo. Researchers measured days withou…

This study tested a 6-week outpatient rehab program for 125 adults with Long COVID. The program included physical and speech therapy tailored to each person's needs, aiming to improve breathing, thinking, and daily function. Researchers measured progress using a six-minute walk t…

This study tested a mobile app called SleepFix that provides digital behavioral therapy for insomnia in 128 older adults aged 50+ who also had mild memory concerns. Participants either used the app or received online sleep health education. The goal was to see if the app could re…

This study tested a 12-week program that combines cognitive exercises with whole-body vibration in 50 older adults (ages 60-75) who have mild to moderate cognitive impairment. The goal was to see if this training could improve both thinking skills and balance. Participants did 36…

This study looked at whether two types of talk therapy—cognitive behavioral therapy (CBT) and relaxation training—could improve mood and thinking in people with relapsing-remitting multiple sclerosis. 140 participants with mild to moderate disability were randomly assigned to one…

This study tested whether a specially designed occupational therapy program could help people with mild-to-moderate thinking problems after a stroke perform daily activities like dressing or cooking. Only 8 people took part, and the goal was to see if the therapy was practical to…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills in 62 people with depression, bipolar disorder, or psychotic disorders like schizophrenia. Participants practiced daily-life tasks in VR, such as cooking and shopping, guided by…

This completed study tested an online platform called LifeBio Memory that helps collect life stories from people with dementia. The platform uses machine learning to turn spoken memories into personalized storybooks. Researchers wanted to see if this tool could improve mood, redu…

This study tested a program called SHARP-CG for older Black caregivers of people with dementia. Caregivers, their loved ones with dementia, and a support person walked together while using a tablet to look at old neighborhood photos and talk about memories. The goal was to see if…

This study tested a program called ImPACT for brain cancer survivors who have trouble with thinking and memory. The program pairs each survivor with a carer to identify strengths and challenges, and create practical strategies for daily life. The trial enrolled 27 survivors and t…

This study tested a three-week program where healthy adults and people with depression or bipolar disorder did cognitive training inside a room with low oxygen (like being at 4,400 meters altitude). The goal was to see if the combination improves memory, attention, and executive …

This study tested whether listening to personalized music can improve thinking and daily function in people with advanced-stage Alzheimer's disease. Researchers enrolled 54 older adults and had them listen to either their favorite music or a classical piece. The goal was to see i…

This study tested whether virtual reality training or physical activity could improve physical function, thinking, and quality of life in 45 adults with schizophrenia. Participants did either VR gaming or structured exercise for 12 weeks. Researchers measured balance, walking abi…

This study looks at people with severe but symptom-free narrowing of the carotid artery in the neck. It tests whether opening the artery with surgery or stenting can improve memory and thinking problems caused by poor blood flow to the brain. About 385 participants from a larger …

This study looked at 181 elderly patients (65 and older) having emergency non-heart, non-lung surgery. Researchers measured brain oxygen levels during surgery and checked for confusion or memory problems (called postoperative cognitive dysfunction) up to 72 hours later. The goal …

This study looked at whether a single session of different exercises—qigong, brisk walking, or elastic band workouts—could improve cognitive flexibility (the ability to switch between tasks) in 60 older adults with mild cognitive impairment. Participants did 30 minutes of moderat…

This study tested whether a lifestyle program delivered through a smartphone app could help older adults (ages 60-77) at risk for dementia. 156 participants in four countries were split into two groups: one received a structured program with app support and in-person sessions, wh…

This study tested a program called SHARE that helps older adults with memory problems and their families talk about healthcare wishes with their primary care doctor. About 273 people took part. The program provided tools and guidance to improve communication and advance care plan…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This small study tested whether a nurse-led walking and sit-to-stand program is practical and liked by older adults with cognitive issues like dementia who are in transitional care after a hospital stay. Six people took part, and the researchers measured how many joined, stayed, …

This study tested a simpler version of a cube-building puzzle to see if it can be used at a patient's bedside to assess planning and problem-solving skills. Researchers worked with 30 healthy volunteers to identify any practical issues with the new test. The goal is to develop a …

This study tested whether a community health worker (CHW) can help people with dementia and their family caregivers after a hospital stay. The CHW provided education, care planning, and support through home visits and phone calls. The goal was to see if the program was feasible a…

This study tested a program that screens older adults (60+) for memory and thinking problems after they leave the intensive care unit (ICU). The goal was to see if it's possible to identify issues like mild cognitive impairment or dementia early. 109 people took part, and the stu…

This completed study looked at 115 obese patients undergoing hip or heart surgery to see if inflammation in their fat tissue is linked to confusion or memory problems after the operation. Researchers collected blood and fat tissue samples during surgery and tracked patients' thin…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other brain-related chemicals, before and after the program. The goal was t…

This completed study looked at 170 smokers with COPD to understand how lung damage affects brain structure and thinking skills. Participants took memory and thinking tests, had lung function tests, and underwent brain scans. The goal was to find early clues that could one day lea…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild memory problems. Fifty-three volunteers aged 60 and over took part in the training. The goal was to see if this creative activity cou…

This study tested a computer program that helps primary care doctors identify older adults who might have early memory loss or dementia. Over 3,200 patients aged 65 and older took part. The tool uses information from electronic health records to flag patients who may need further…

This study tested a special device that sprays insulin into the nose to see how much gets into the brain. Twenty people with mild memory problems or normal thinking took part. The goal was to measure insulin levels in spinal fluid and check if it helps memory. This is an early st…

This study tested a program called Home Alone for older adults (55+) with mild cognitive impairment or memory loss who live alone. The program involves weekly one-hour coaching sessions over several months to help participants stay engaged, active, and safe at home. Researchers m…

This completed study examined 129 older adults having elective orthopedic surgery under regional anesthesia. Researchers measured cognitive frailty and collected blood and spinal fluid to look for biomarkers of brain inflammation and degeneration. The goal was to see if these bio…

This study looks at whether blood vessel health is linked to memory decline in older adults with high blood pressure who have memory complaints. Researchers will measure artery stiffness, brain scans, and cognitive tests in 131 participants over time. The goal is to understand if…

This completed trial looked at whether combining two types of cognitive rehabilitation—restorative and compensatory—can improve executive functions in people who had a stroke and now have mild cognitive impairment. Thirty-six participants, aged 50 to 70, did exercises like naming…

This study tested whether music therapy can protect cognitive function and wellbeing in healthy older adults and those with mild-to-moderate cognitive decline. Over 5 months, 210 participants received one-on-one, small group, or large group music therapy, sometimes with robotic a…