COGNITIVE IMPAIRMENT

This study tested whether a drug called EG-501 could improve thinking and memory problems, often called 'brain fog,' in people with lupus. 131 adults with lupus and confirmed cognitive impairment were randomly assigned to receive either EG-501 or a placebo (inactive substance) fo…

This study tested whether a nasal insulin spray and a diabetes pill (empagliflozin), alone or together, could help people with early memory loss or Alzheimer's disease. It involved 47 adults aged 55-85 who showed early signs of Alzheimer's. The main goal was to check if the treat…

This study tested whether a new, multi-channel brain stimulation technique (tDCS) works better than the standard method or a fake treatment for major depression. It involved 60 adults with moderate-to-severe depression. Researchers measured changes in depression symptoms, thinkin…

This study tested a special nasal spray device designed to deliver insulin directly to the brain. Researchers wanted to see if this method could increase insulin levels in the fluid surrounding the brain and potentially improve memory. The study involved 20 people, some with mild…

This study tested whether an intravenous form of the drug guanfacine could help treat delirium (acute brain confusion) in patients who are critically ill in the ICU. The goal was to see if the treatment could reduce the number of days patients experienced delirium or coma, help t…

This study tested whether a special three-week program could improve thinking skills. Participants, including healthy adults and people with stable depression or bipolar disorder, spent time in a room with low oxygen levels (like being at high altitude) while doing brain-training…

This study tested whether combining two different brain training approaches could help stroke survivors with mild thinking problems. Researchers worked with 36 participants who had experienced a stroke and had mild cognitive impairment. They compared different rehabilitation tech…

This study tested whether a 12-week intensive exercise program could improve thinking skills, blood sugar control, and overall health in middle-aged and older adults with type 2 diabetes. Researchers enrolled 58 participants, some of whom were at higher risk for memory and thinki…

This study tested a computer program designed to help primary care doctors identify older adults at risk for dementia or memory loss. The tool, integrated into the clinic's electronic health record, flagged at-risk patients and gave doctors resources for next steps like assessmen…

This study tested a new program designed to check for memory and thinking problems in older adults after they leave the intensive care unit (ICU). It involved 109 people aged 60 and older who had a long ICU stay. The program screened patients at 6 weeks and 6 months after dischar…

This study tested whether a 24-week home-based program of physical activity and brain training could prevent or delay memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older who were at high risk for memory decline. They compared different …

This study tested a new brain training program designed to help people who have survived brain cancer but are struggling with memory, thinking, or behavior changes. The program involved both the patient and a family caregiver to help practice new skills at home. Researchers wante…

This small study tested whether a new occupational therapy program is practical to run for people who have trouble with daily activities after a stroke due to thinking problems. The therapy was designed by neuropsychologists and occupational therapists to help with tasks like get…

This study tested whether taking capsules containing healthy gut bacteria from a donor (fecal microbiota transplantation) could improve sleep for people with chronic insomnia. 80 participants were randomly given either the real treatment capsules or identical-looking placebo caps…

This study tested whether listening to personally meaningful music could help people with advanced Alzheimer's disease. It involved 54 participants aged 65 and over who listened to personalized music. Researchers measured if this improved their daily living skills, memory, and th…

This study tested whether a digital sleep therapy app could reduce insomnia in adults aged 50 and older who also reported memory or thinking problems. Researchers compared the app, which guides users through sleep improvement techniques, against basic online sleep education. The …

This study tested a new home-based coaching program designed to help older adults with memory loss who live alone. The program involved weekly meetings with a coach to help participants stay active, safe, and socially connected at home. Researchers wanted to see if the program wa…

This study compared two different activity programs to see which might better help people with schizophrenia. Researchers tested whether regular physical exercise or training using virtual reality (VR) could improve physical abilities, thinking skills, and quality of life. The st…

This study tested a program called SHARP-CG, designed to support older Black caregivers of people with dementia. Small groups walked together three times a week for 16 weeks, using a tablet to view historical photos of their neighborhood as conversation starters. Researchers meas…

This study tested whether a 4-week virtual reality (VR) brain training program could improve thinking skills and daily functioning in people with stable depression, bipolar disorder, or schizophrenia. 62 participants were randomly assigned to receive either the active VR cognitiv…

This study tested a new online tool designed to make it easier for caregivers to help people with dementia share their life stories. The tool uses speech-to-text and artificial intelligence to create personal storybooks from conversations. Researchers wanted to see if using these…

This study tested whether a friendly robot could help people with dementia or memory problems feel more socially connected and engaged. For three weeks, residents, their families, and staff in an assisted living community tried using a robot that led activities like trivia and ga…

This study tested a 6-week outpatient rehabilitation program designed to help people with Long COVID. The program included tailored physical therapy, breathing exercises, and brain training to address common symptoms like fatigue, shortness of breath, and thinking problems. Resea…

This study tested whether music therapy could help older adults maintain their thinking skills and improve their quality of life. It involved 210 people aged 65 and over, including those who were healthy and those with mild to moderate memory or thinking problems. Researchers com…

This study tested whether two types of group talk therapy could help people with multiple sclerosis (MS) feel better and think more clearly. Researchers compared a cognitive behavioral therapy (CBT) program and a psychophysiological regulation therapy to standard care in 140 part…

This study tested a new way to provide hearing care to people living with dementia at home. A speech-language pathologist delivered affordable hearing help instead of an audiologist. Researchers wanted to see if this improved patients' behavioral symptoms and overall quality of l…

This study tested whether two types of gentle, non-invasive electrical brain stimulation could improve thinking skills like memory and problem-solving in people with schizophrenia. Thirty-six adults with schizophrenia received different stimulation types in a random order to see …

This study tested whether a special exercise program that combines mental tasks with physical movement, plus whole-body vibration therapy, could help improve thinking skills and balance in older adults with mild to moderate memory and thinking problems. Fifty participants aged 60…

This small pilot study tested a new program designed to help older adults who have both long-term pain and mild memory problems. Participants received weekly phone calls from a health coach and watched educational videos to learn pain management skills. Researchers wanted to see …

This study aimed to understand why some people experience confusion and memory problems after surgery, a condition known as post-operative cognitive dysfunction (POCD). Researchers followed 115 patients having hip or heart surgery to see if inflammation from body fat, especially …

This study aimed to understand how exercise might help protect the aging brain. Researchers had 60 healthy but inactive adults aged 50-80 complete a 12-week, supervised exercise program. They measured changes in thinking skills and specific hormones in the blood before and after …

This study explored whether taking music improvisation classes could help improve self-regulation and thinking skills in older adults. Researchers enrolled 53 adults aged 60 and over, some with mild memory concerns and some without, to test the new training program. The goal was …

This study looked at 129 older adults having planned orthopedic surgery to see if certain markers in their blood and spinal fluid were linked to physical frailty and thinking problems before their operation. Researchers wanted to understand if these markers could help identify pa…

This study aimed to understand if the health of a person's blood vessels is linked to changes in their memory and thinking skills over time. It followed 131 older adults with high blood pressure who had concerns about their memory. Researchers measured blood vessel stiffness and …

This study aimed to understand why many people with COPD (a serious lung disease often from smoking) also experience problems with memory and thinking. Researchers examined 170 smokers, some with early signs of lung damage, using brain scans and thinking tests. The goal was to id…