COGNITIVE IMPAIRMENT

This study tested whether a nasal insulin spray combined with the diabetes drug empagliflozin can safely improve memory and thinking in people with early Alzheimer's or mild cognitive impairment. 47 adults aged 55-85 with signs of Alzheimer's in their brain took part. The goal wa…

This study tested an experimental drug called EG-501 for people with lupus who experience cognitive impairment, often called "brain fog." The trial involved 131 participants who received either the drug or a placebo for 14 weeks. The goal was to see if EG-501 could safely improve…

This study looked at whether a home-based physical activity program and computer-based cognitive training, alone or together, could prevent memory loss in older women with heart disease. 253 women aged 65 and older with cardiovascular disease but no regular exercise or cognitive …

This study tested a hearing program delivered by a speech-language pathologist for older adults with both hearing loss and dementia. The goal was to see if improving hearing access could reduce troubling symptoms like agitation or mood changes. 77 people with mild to moderate dem…

This study looked at whether two types of psychological therapy could help people with relapsing-remitting multiple sclerosis who also have anxiety, depression, or thinking problems. 140 people took part and were randomly assigned to cognitive behavioral therapy, relaxation thera…

This study tested a 12-week intensive aerobic and resistance exercise program in 58 adults aged 40-85 with type 2 diabetes and mild cognitive issues. Researchers measured changes in thinking skills, blood sugar, inflammation, and physical function. The goal was to see if exercise…

This study looked at whether virtual reality training or physical activity works better to improve physical function, thinking skills, and quality of life in people with schizophrenia. 45 adults with schizophrenia took part. The goal is to find new ways to help manage symptoms an…

This study tested whether a 4-week virtual reality (VR) training program could improve thinking skills and daily functioning in 62 adults with stable mood disorders (like depression or bipolar disorder) or psychosis spectrum disorders (like schizophrenia). Participants used VR to…

This study tested whether a drug called galantamine, combined with a specific brain-training program, could improve thinking and memory in people who had a first stroke 3 months earlier. 47 adults aged 35-70 took part. The goal was to see if the combo helped brain activity and da…

This study tested whether an optimized multichannel tDCS device can better ease depression symptoms compared to standard or sham (fake) tDCS. Sixty adults with moderate-to-severe major depression received one of the three tDCS types. Researchers measured mood changes using standa…

This study tested a 7-week phone-based program to help older adults with both chronic pain and mild memory problems manage their pain better. Participants received weekly calls from a community health worker and watched educational videos. The goal was to see if the program was p…

This study tested a 6-week outpatient rehab program for 125 adults with Long COVID. The program included exercises for breathing, strength, balance, and thinking skills. The goal was to see if it helps people walk farther and feel better in daily life.

This study looked at whether walking while doing simple thinking tasks (like counting or naming things) can help older adults with brain fog. 90 people aged 65+ with brain fog took part. They were split into two groups: one walked while doing mental tasks, the other just walked. …

This study tested whether fecal microbiota transplantation (FMT) — giving healthy donor gut bacteria in a capsule — can improve sleep in people with chronic insomnia. 80 adults took either FMT capsules or placebo starch capsules. Researchers measured sleep quality using sleep stu…

This study tested a special training program that combines thinking exercises with whole-body vibration (standing on a gently vibrating platform) to see if it helps older adults with mild to moderate memory and balance problems. Fifty adults aged 60 to 75 with cognitive impairmen…

This study looked at whether listening to personalized music can improve thinking and daily living skills in people with advanced Alzheimer's disease. 54 older adults with advanced-stage Alzheimer's took part. Researchers measured changes in memory, attention, and independence be…

This study tested whether digital or physical brain games can improve thinking, mood, and quality of life in 514 older adults with mild-to-moderate Alzheimer's disease. Participants did one-on-one cognitive stimulation activities, either on a computer or with traditional material…

This study tested a digital sleep therapy program (dBTi) in 128 adults aged 50+ who had trouble sleeping and reported memory concerns. Participants used either the sleep therapy app or received online sleep health education for 8 weeks. The goal was to see if the app could reduce…

This study tested whether a medicine called guanfacine, given through an IV, can help critically ill patients in the ICU have fewer days of confusion or unconsciousness. 46 adults on breathing machines or with shock took part. The goal was to see if the drug could improve brain f…

This study tested whether combining a personalized exercise program (aerobic, strength, and balance) with a gentle vibrating device on the legs could improve muscle health, frailty, and thinking skills in older adults living in care homes. Forty people over age 75 took part. The …

This study tested whether a 40-hour, 8-week cognitive telerehabilitation program done at home could reduce the risk of long-term thinking problems after a stroke. 86 adults who had a recent stroke took part. The treatment group did the home program, while the control group receiv…

This study tested an online platform called LifeBio Memory that helps people with dementia and their caregivers share and record life stories. The platform uses machine learning to turn speech into text, making it easier to create personalized life story materials. 234 residents,…

This study tested whether mild electrical stimulation to the brain (tDCS and tRNS) could improve memory and thinking in 36 adults with schizophrenia. Participants completed thinking tasks after receiving different types of stimulation. The goal was to see if these safe, non-invas…

This study tested a program where older Black caregivers, their loved ones with dementia, and a support person walked together while looking at old neighborhood photos on a tablet. The goal was to improve caregivers' sleep, mood, and overall health. Twenty-one people took part, a…

This study tested a new cognitive rehabilitation program for brain cancer survivors who have trouble with thinking and memory. 27 survivors and their carers took part. The program aimed to help with daily thinking skills and quality of life. Results will show if the program is he…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other markers linked to brain health. The goal was to understand how exerci…

This study tested whether a new type of occupational therapy could help people with mild-to-moderate thinking problems after a stroke manage daily tasks like dressing or cooking. Only 8 people took part, and the goal was to see if the therapy was practical to deliver and study, n…

This study tested a special device that delivers insulin through the nose to see how much gets into the brain. Insulin is a hormone that helps control blood sugar, but it may also affect memory. The study included 20 people with mild memory problems or normal cognition. Researche…

This study tested whether a nurse-led walking and sit-to-stand program is practical and liked by older adults with cognitive issues like dementia in transitional care. Six participants took part to see if the program could improve strength, mobility, and quality of life. The main…

This study tested a new, simpler version of a thinking test called Link's Cube, which measures a person's ability to plan and solve problems. Researchers wanted to see if using fewer, larger blocks would work just as well as the original 27-block version. The study involved 30 he…

This study tested a program called SHARE that helps older adults with memory problems and their family caregivers talk to their primary care doctor about future healthcare wishes. About 248 patient-caregiver pairs took part, with half getting the SHARE program and half getting us…

This study tested whether combining two types of cognitive rehabilitation (restorative and compensatory) could improve thinking skills in people who had a stroke and have mild cognitive impairment. 36 participants aged 50-70 were enrolled. The goal was to see if this combined app…

This study tested a computer system that helps doctors identify older patients at risk for memory problems or dementia. Over 3,200 adults aged 65 and older took part. The system used health records and risk models to alert doctors, aiming to improve early detection and care plann…

This study tested a three-week program where healthy adults and people with depression or bipolar disorder did brain-training exercises in a room with low oxygen (like high altitude). The goal was to see if this combination improves memory, focus, and problem-solving. Researchers…

This study tested whether a community health worker (CHW) program is practical and well-liked by people with dementia and their caregivers after leaving the hospital. Researchers enrolled 34 patients and their caregivers to receive telephone support from a CHW coach. The goal was…

This study looked at 115 patients to see if inflammation in belly fat (white adipose tissue) causes confusion or memory problems after surgery. Researchers measured thinking skills and inflammation levels before and after hip or heart surgery. The goal was to understand why obese…

This study looked at whether music therapy, sometimes with the help of robots, can protect thinking skills and well-being in older adults. Over 200 healthy seniors and those with mild-to-moderate memory problems took part in 5 months of music sessions. Researchers measured change…

This study tested a social robot that plays trivia and gives reminders to people with Alzheimer's or other dementias living in assisted care. The goal was to see if the robot helps improve engagement, mood, and quality of life. 26 residents, family members, and staff took part. T…

This study looked at 129 older adults (over 65) having orthopedic surgery to see if certain substances in the blood and spinal fluid are linked to frailty and thinking problems. The goal was to find early warning signs for cognitive decline in vulnerable patients. The research wa…

This study looked at whether giving insulin through the nose can help people with mild memory problems. Researchers measured how much insulin reached the brain fluid and checked if it improved memory. The study involved 13 adults who were either healthy or had mild cognitive impa…

This study tested a program called Home Alone for adults aged 55+ with mild memory or thinking problems who live alone. The goal was to see if the program was useful and acceptable. Participants worked with a coach in weekly one-hour sessions over 3 to 6 months, and the study mea…

This study looks at whether blood vessel problems can help explain memory decline in older adults with high blood pressure who have memory complaints. Researchers will measure artery stiffness and brain scans in 131 participants over time. The goal is to better understand the lin…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild cognitive impairment. 53 participants aged 60+ with little to no music background took part. The goal was to see if improv training c…

This study tested a program that screens older adults (60+) for memory and thinking problems after a stay in the intensive care unit (ICU). About 109 people took part to see if the screening was practical and helpful. The goal was to find cognitive issues early and connect patien…

This study looked at how lung damage from COPD might change the brain and thinking skills in smokers. Researchers used brain scans and thinking tests in 170 adults aged 30-85. The goal was to find early clues to prevent or delay memory and thinking problems.