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Diabetes drug metformin tested to boost brain recovery in young cancer survivors

NCT ID NCT05230758

Recruiting now Symptom relief Sponsor: Donald Mabbott Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether metformin, a widely used diabetes drug, can improve memory and thinking in children and teens who have finished treatment for a brain tumor. About 140 participants aged 7 to 21 will take metformin or a placebo for 16 weeks. Researchers will measure changes in memory, processing speed, and brain growth using tests and brain scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Metformin (a diabetes drug repurposed for brain recovery)
What this could lead to
If it works, this could offer a safe, affordable way to help children recover memory and thinking skills after brain tumor treatment.
What could go wrong
This is still a trial—metformin may not improve cognition more than placebo. The treatment is short (16 weeks), and long-term benefits are unknown.

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Conditions

The condition(s) this trial relates to.

childhood germ cell tumor childhood medulloblastoma Cognitive Dysfunction craniopharyngioma ependymoma medulloblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE IMPAIRMENT MEDULLOBLASTOMA, CHILDHOOD

Contacts and locations

Locations

  • Alberta Children's Hospital

    RECRUITING

    Calgary, Alberta, T3B 6A8, Canada

  • CHU Sainte-Justine

    RECRUITING

    Montreal, Quebec, H3T 1C5, Canada

  • CHU de Québec - Université Laval

    RECRUITING

    Québec, Quebec, G1V 4G2, Canada

  • CHU de Sherbrooke

    RECRUITING

    Sherbrooke, Quebec, J1G 2E8, Canada

  • Cancer Care Manitoba

    RECRUITING

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Children's & Women's Health Centre of British Columbia

    RECRUITING

    Vancouver, British Columbia, V6H 3V4, Canada

  • Children's Hospital in Westmead

    WITHDRAWN

    Westmead, New South Wales, 2145, Australia

  • Children's Hospital of Eastern Ontario

    RECRUITING

    Ottawa, Ontario, K1H 8L1, Canada

  • Children's Hospital, London Health Sciences Centre

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • Hamilton Health Sciences - McMaster Children's Hospital

    RECRUITING

    Hamilton, Ontario, L8S 4K1, Canada

  • Izaak Walton Killam (IWK) Health Centre

    RECRUITING

    Halifax, Nova Scotia, B3K 6R8, Canada

  • John Hunter Children's Hospital

    RECRUITING

    New Lambton Heights, New South Wales, 2305, Australia

  • Monash Children's Hospital

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • Montreal Children's Hospital

    RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

  • Perth Children's Hospital

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Royal Children's Hospital

    RECRUITING

    Parkville, Victoria, 3052, Australia

  • Saskatchewan Health Authority

    RECRUITING

    Saskatoon, Saskatchewan, S7N 0W8, Canada

  • Stollery Children's Hospital

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

  • The Hospital for Sick Children

    RECRUITING

    Toronto, Ontario, M5G 1X8, Canada

  • Women and Childen's Hospital

    RECRUITING

    Adelaide, North Adelaide, SA 5006, Australia

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