Unc Lineberger Comprehensive Cancer Center

This study tested whether adding a bone-strengthening drug (denosumab) to a standard immunotherapy could improve the body's ability to fight advanced melanoma. It involved 25 adults with stage III or IV melanoma who had not yet received certain immunotherapies. Researchers took b…

This study tested whether a three-part treatment approach could reduce side effects and improve outcomes for people with head and neck cancer. Forty patients received chemotherapy first to shrink tumors, followed by minimally invasive surgery, and then radiation/chemotherapy tail…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy could better shrink tumors before bladder removal surgery. It involved 39 adults with muscle-invasive bladder cancer who were scheduled for surgery. The goal was to see if th…

This study looked at whether adding physical and occupational therapy consultations when patients are admitted for a bone marrow transplant helps them recover better. Researchers compared 75 patients' outcomes before and after making this therapy a standard part of admission. The…

This study tested a personalized immune cell therapy for adults with a hard-to-treat type of testicular cancer that had come back or worsened after standard treatments. Doctors collected and modified a patient's own immune cells (T cells) to better target and attack cancer cells.…

This study tested whether combining two targeted drugs, palbociclib and cetuximab, could help control advanced colon cancer that has spread. It involved 24 patients whose cancer had specific genetic features and who had already tried other treatments. The goal was to see if hitti…

This study tested whether adding a special anti-cancer cream after standard surgery could better treat cervical precancer in women living with HIV. Researchers wanted to see if this two-step approach was practical and acceptable to 180 women in South Africa. The goal was to lower…

This small, completed pilot study tested whether a 6-month smartphone app program was practical and acceptable for helping young adult cancer survivors manage their weight. The program used an app, a smart scale, and an activity tracker to help with diet and exercise. Researchers…

This study tested whether high-intensity interval training (HIIT) before standard surgery could slow the growth of endometrial cancer. Thirty women with early-stage endometrial cancer completed personalized HIIT workouts before their hysterectomy. Researchers measured changes in …

This small pilot study tested whether a 3-month digital program could help young adult cancer survivors become more active and eat healthier. The program used a smartphone app, lessons, and optional features like text messages and simplified food tracking. Researchers measured if…

This study aimed to find the most effective advertisements to encourage people who smoke menthol cigarettes to quit. Researchers showed over 1,200 US adults different types of anti-smoking ads in an online survey. They measured which ads made people feel most motivated and confid…

This study tested two ways to train clinic staff on how to better communicate with parents about the HPV vaccine. Researchers compared training delivered by an outside expert to training delivered by a respected 'vaccine champion' from within the clinic's own healthcare system. T…

This study tested whether adding graphic images to warning labels on little cigars and cigarillos could prevent teenagers from starting or continuing to use these tobacco products. Researchers surveyed 928 young people aged 15-20 who were either current users, had tried these pro…

This study tested whether putting warning labels on e-cigarette devices and refills could help people quit vaping. Researchers randomly assigned over 1,300 adult vapers to receive either neutral messages, text warnings, or picture warnings on their vaping supplies. The main goal …

This study tested whether having a financial navigator could help cancer patients manage the high costs of treatment and reduce their financial stress. It involved 258 patients from both rural and non-rural clinics in North Carolina who were struggling with treatment expenses. Pa…

This study tested a mobile app designed to help Black women with breast cancer learn about nearby clinical trials. Researchers wanted to see if the app was easy to use and if it helped women discuss trials with their doctors. The study involved 80 participants who used the app al…

This study aimed to understand how people notice and emotionally react to health warnings on little cigars and cigarillos. Researchers tracked the eye movements and skin responses of 90 current cigar users as they looked at different package designs. The goal was to gather eviden…

This study aimed to understand how often patients with chronic lymphocytic leukemia or multiple myeloma experience financial difficulty due to their cancer treatment. Researchers surveyed 218 patients and their doctors to measure the financial burden, identify what types of costs…

This study tested whether a detailed health survey could help identify and address problems in women aged 70+ after their main breast cancer treatment. Researchers gave the survey results to the patients' doctors and made specialist referrals when needed. The main goal was to see…

This study tested whether a blood test that looks for tiny pieces of cancer DNA could be used to monitor people with muscle-invasive bladder cancer. One participant undergoing standard treatment had their blood and urine collected at different times. The main goal was to see if c…