Unc Lineberger Comprehensive Cancer Center

This study tested whether adding denosumab (a bone-strengthening drug) to standard immunotherapy (pembrolizumab or nivolumab) could help control advanced melanoma that has spread. Twenty-five adults with stage III or IV melanoma that had not been treated with immunotherapy before…

This study looked at whether adding an anti-cancer cream (5-fluorouracil) after surgery is an acceptable and useful way to treat cervical precancer in 180 women with HIV in South Africa. The goal was to see if women would stick with the treatment and find it acceptable. The appro…

This study tested a personalized three-step treatment for head and neck cancer that combines chemotherapy, surgery, and radiation. The goal was to see if this approach could reduce harmful side effects while still effectively controlling the disease. Forty adults with previously …

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 adults with a specific type of metastatic colon cancer that had not responded to standard treatments. The goal was to see if the combination could shrink or stabilize tumors. While the treatment aimed …

This study tested whether artesunate vaginal inserts, a medicine used for malaria, can help clear HPV after standard cervical precancer treatment in women living with HIV. 120 women in Kenya used the inserts or a placebo for 5 days on, 1 week off, over 3 cycles. The goal was to s…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (gemcitabine and cisplatin) could shrink tumors more effectively before bladder removal surgery in people with muscle-invasive bladder cancer. 39 participants received the co…

This study looked at whether stronger warning labels on little cigars and cigarillos (LCCs) can reduce teens' and young adults' desire to use them. Nearly 1,000 participants aged 15-20 who had used or were open to using LCCs completed surveys about their willingness to use these …

This study looked at whether measuring tiny bits of tumor DNA in blood and urine (called ctDNA) is possible in people with muscle-invasive bladder cancer receiving standard treatment. Researchers collected samples before, during, and after therapy to see if ctDNA levels could hel…

This study tested whether putting warning labels directly on e-cigarette devices makes people want to quit vaping, without causing them to switch to smoking. Over 1,300 adult vapers had their devices labeled with either a control message, text warning, or picture warning. Researc…

This study looked at whether high-intensity interval training (HIIT) before standard surgery could have anti-cancer effects in women with endometrial cancer. Thirty women participated, and researchers measured changes in tumor growth markers in tissue samples taken before and aft…

This study tested whether a mobile app-based weight loss program is practical and well-liked by young adults who survived cancer. Researchers enrolled 63 survivors aged 18-39 and used a smartphone app with activity tracking and diet logging. The goal was to see if people would jo…

This study tested a financial navigation program for 258 cancer patients in rural and non-rural North Carolina clinics. The goal was to see if helping patients manage costs could reduce financial toxicity and improve quality of life. Participants had high financial distress and r…

This study looked at whether adding physical and occupational therapy consultations for adults admitted for a bone marrow transplant could improve outcomes. Researchers compared patients who received therapy with historical data to see if it reduced hospital stays, readmissions, …

This study tested different ads to see which ones best encourage people who smoke menthol cigarettes to quit. Over 1,200 US adults aged 21 and older rated the ads online. The goal is to find the most effective messages for future quit-smoking campaigns.

This study tested a new treatment using a patient's own modified T cells (called CAR T cells) to target a protein called CD30 on nonseminomatous germ cell tumors, a rare type of testicular cancer. Only 2 adults who had already tried at least one other treatment took part. The mai…

This study tested a mobile health app designed to help Black women with breast cancer learn about and join clinical trials. Researchers worked with 80 participants to see if the app was easy to use and helpful. The goal was to understand how well the app fits into clinic routines…

This study looked at whether it's possible to repeatedly measure muscle mass, physical function, and biological aging in children (ages 8-21) with newly diagnosed solid tumors or lymphoma during cancer treatment. Researchers used simple tests like walking and grip strength, along…

This study surveyed 218 adults with chronic lymphocytic leukemia or multiple myeloma to learn about the financial difficulties they face from cancer treatment. Researchers asked patients about money problems over the past year and also surveyed doctors and clinics. The goal is to…

This study looked at women aged 70 and older who finished early-stage breast cancer treatment within the past two months. Researchers used a geriatric assessment survey to find symptoms and issues, then shared results with the medical team to make referrals. The goal was to see i…

This study looked at how removing flavor descriptions from little cigar and cigarillo packages changes how people notice and react to health warnings. Researchers used eye-tracking and skin sensors to measure attention and emotional responses in 90 adult tobacco users. The goal i…

This study tested a mobile program designed to help young adult cancer survivors (ages 18-39) eat healthier and be more physically active. 72 survivors joined the pilot trial to see if the program was easy to use and liked by participants. The goal was to learn if this approach c…

This study tested two approaches to help doctors talk to families about the HPV vaccine. Some clinics got training from an outside expert, while others learned from a vaccine champion within their own healthcare system. Researchers looked at vaccination records of 9-12 year olds …