Could a cream after surgery stop cervical cancer in HIV-Positive women?
NCT ID NCT05413811
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is an acceptable and feasible way to treat cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it acceptable, not yet to prove it works. It's an early step toward possibly preventing cervical cancer in this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 5-fluorouracil cream
- What this could lead to
- If this combination approach is acceptable and effective, it could offer a better way to prevent cervical cancer in women with HIV.
- What could go wrong
- This was a small, early feasibility study (180 participants) focused on acceptability, not proof of cure. The results may not apply to all women or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CERVICAL CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Clinical HIV Research Unit Temba Lethu Wing Helen Joseph Hospital
Westdene, Johannesburg, 2092, South Africa
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new drug combo revive Immunotherapy's power against resistant tumors?
- Can an antiviral make radiation more effective against cervical cancer?
- A One-Two punch against cervical cancer: testing plus vaccination in HIV-Positive women
- Can a Two-Antibody combo outsmart advanced cancer?
- Can robotic surgery match open surgery in beating cervical cancer?
- Blood test clues could sharpen cervical cancer treatment