Unc Lineberger Comprehensive Cancer Center

This study is for people with muscle-invasive bladder cancer who are scheduled for surgery but cannot take standard chemotherapy beforehand. Researchers want to see how two different drug combinations affect the immune system and the tumor. One group gets an immunotherapy drug (p…

This study tested a new combination of cancer drugs for people with an aggressive type of lymphoma (DLBCL) that has returned or did not respond to the first treatment. The goal was to see if adding a newer targeted drug (polatuzumab vedotin) to a standard chemotherapy mix could b…

This study is testing if a standard four-drug treatment for multiple myeloma works just as well when given on a simpler, once-a-week schedule instead of twice a week. It involves 39 adults newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. The main…

This early-stage study is testing the safety of a new type of personalized cell therapy for adults with B-cell lymphoma that has come back or not responded to other treatments. Doctors take a patient's own immune cells (T cells), modify them in a lab to better target cancer, and …

This study is testing a combination of three drugs for multiple myeloma that has returned or stopped responding to prior treatments. It specifically aims to see if using lower doses of two of the drugs is safe and effective for older patients or those who are too frail for standa…

This study is testing a three-step treatment for people with advanced head and neck cancer that can be removed by surgery. First, patients receive a combination of three drugs (carboplatin, nab-paclitaxel, and durvalumab) to try to shrink the cancer. Then, they have surgery. Fina…

This is an early-stage study testing the safety of a new cell therapy for adults with multiple myeloma that has come back or stopped responding to standard treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to better recognize and attack cancer …

This study is testing a new cell therapy for people whose Hodgkin's or Non-Hodgkin's lymphoma has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them back into th…

This study is testing a new type of personalized cell therapy for adults whose CD30+ lymphomas have come back or not responded to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify them to better find and attack cancer cells, and then inf…

This study is testing a new type of treatment for people whose acute lymphoblastic leukemia (ALL) has come back or hasn't responded to other therapies. Doctors take a patient's own immune cells (T cells), genetically modify them to better find and attack leukemia cells, and add a…

This study is testing whether adding two drugs, pembrolizumab and olaparib, before and after standard chemoradiation can better control a difficult-to-treat form of head and neck cancer. It will involve about 45 adults with locally advanced cancer who have not had prior treatment…

This study is testing whether a radiation treatment for small liver cancer tumors can be safely done in one day instead of two. Researchers aim to simplify the process for 30 patients by removing a safety scan they believe is unnecessary for small tumors. The goal is to reduce pa…

This early-phase study is testing the safety of a new cell therapy for women with recurrent ovarian cancer that hasn't responded to standard treatments. Doctors modify a patient's own immune cells to recognize and attack cancer cells, then infuse them back into the abdomen. The m…

This study is testing whether the drug rituximab is safe and effective for treating multicentric Castleman disease in Malawi. The trial involves 15 adults with active disease who receive four weekly doses of rituximab, with some higher-risk patients also receiving chemotherapy. R…

This study is testing whether a vaginal insert (artesunate) can help clear HPV infection and prevent cervical precancer from returning in women living with HIV. It aims to improve the success of standard thermal ablation treatment, which often fails in this high-risk group. The t…

This study is testing whether giving clinics financial bonuses can help doctors communicate better and get more children vaccinated against HPV. It involves 34 clinics in North Carolina, where some clinics get communication training and others get the same training plus a bonus p…

This study aimed to see if regular clinic visits and a pneumonia vaccine could help prevent infections in cancer patients after they received CAR-T cell therapy. The plan was to enroll 50 adults with blood cancers or solid tumors who were getting this specialized treatment. Resea…

This study is testing whether a physical activity program, co-created with the community, is practical and helpful for Black colorectal cancer survivors. Researchers are measuring if the program improves quality of life, reduces symptoms like fatigue and pain, and increases daily…

This study aimed to test whether using detailed MRI scans to guide radiation treatment could help reduce severe, long-lasting dry mouth in people receiving radiation for throat cancer. Researchers planned to compare a new approach that specifically avoids damaging key saliva duct…

This study aims to build a database to help researchers understand the autoimmune-like side effects that can occur from powerful cancer immunotherapy drugs. It will collect health data and samples from 32 adult cancer patients receiving these treatments. The goal is to learn who …

This study aims to understand how cancer treatment affects children's muscle mass, physical strength, and aging markers. Researchers will measure 28 children ages 8-21 at diagnosis, during treatment, and after treatment using simple tests and routine scans. The goal is to learn h…

This study aims to understand how early breast cancer treatment affects women's quality of life and daily function years after they finish therapy. Researchers are following 253 women who are cancer-free for at least three years, comparing those who received chemotherapy to those…

This study aims to find out if it's practical to use online questionnaires to track symptoms in gynecologic cancer patients before, during, and after radiation therapy. It involves 100 patients at a high-volume clinic. The goal is to gather detailed information on how symptoms ch…

This study observes how HIV-related Kaposi Sarcoma, a type of cancer, responds to standard chemotherapy treatments given in Malawi and South Africa. It follows 127 adult patients already receiving standard care to understand why outcomes vary and identify markers that could predi…

This study aimed to see if a special imaging scan (FFNP PET/MRI) could predict whether a hormone-releasing IUD would successfully treat early endometrial cancer or a precancerous condition. It planned to enroll 8 women who were scheduled to receive this IUD treatment. The goal wa…