QUALITY OF LIFE

This study tests whether giving ICU patients extra protein and activating their muscles early can prevent muscle loss. About 40 critically ill adults on breathing machines will be split into two groups: one gets standard care, the other gets extra protein and muscle stimulation. …

This study looks at three ways to correct nearsightedness in children aged 7-17: regular glasses, special glasses that blur peripheral vision, and overnight contact lenses. Researchers will track how each method affects quality of life, how well it works, and how much it costs ov…

This study looks at whether a dual bronchodilator can improve both breathing and heart function in people newly diagnosed with moderate-to-severe COPD. Researchers will measure exercise capacity, quality of life, and lung function after 12 weeks of treatment. The study involves 8…

This study follows 384 women who receive Silimed smooth surface breast implants for breast augmentation. Researchers will track any side effects or complications over 10 years, and measure how satisfied patients are with the results. The goal is to better understand the long-term…

This study tests whether smartphone apps and text messages can help African American adults aged 50 and older better manage their blood pressure and stick to their medication routine. About 208 participants will use a mobile health app to track their progress. The goal is to impr…

This study looks at whether giving patients more oxygen during and right after major surgery can lower the chance of wound infections and other complications. About 7,800 adults having planned surgeries will be randomly assigned to receive low, medium, or high levels of oxygen. T…

This study tests a special vacuum dressing (Negative Pressure Wound Therapy) on the incision after emergency abdominal surgery. The goal is to see if it reduces wound problems like infection or reopening compared to a standard bandage. About 720 adults having emergency laparotomy…

This study compares giving a single high-dose radiation treatment versus several smaller doses for people whose cancer has spread to a few places (up to 5 spots). The goal is to see if one session works just as well with fewer side effects and better quality of life. About 598 ad…

This study tests whether adding the drug adebrelimab to standard chemotherapy before surgery can completely eliminate esophageal cancer in 25 patients with stage II/III disease. The main goal is to see if no cancer cells remain after treatment. Researchers will also monitor side …

This study tests whether starting dialysis twice a week instead of the usual three times a week can reduce hospital stays and improve quality of life for older adults (60+) with kidney failure who still produce some urine. The trial will follow 428 participants for up to two year…

This study tests a program to help veterans manage pain and reduce risky substance use after leaving the military. About 1,800 veterans will be assigned to either standard training for case managers or extra support to adopt a new care pathway. The goal is to see if extra support…

This study compares two types of surgery (Parks and Bacon) for people with very low rectal cancer. The goal is to see which method leads to better bowel function and quality of life one year after surgery. About 256 adults aged 18–75 with tumors close to the anal opening will tak…

This study tests whether a treatment plan called total neoadjuvant therapy (TNT) can help about half of rectal cancer patients avoid surgery and keep their rectum. Participants receive chemotherapy and radiation before deciding if they need surgery. Those who respond very well ar…

This study tests whether special air cleaners and ventilators can improve indoor air quality and help control asthma in children and adults living in low-income homes. Over one year, 80 households will receive either active or placebo devices. Researchers will measure lung functi…

This study tests whether a home blood pressure monitoring program with health coaching can help rural adults better control their high blood pressure. About 334 participants will either get the coaching program or a standard health app. The goal is to see if blood pressure and me…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in people with severe brain injuries. About 3,300 adults on ventilators in intensive care will be randomly assigned to recei…

This study tests whether moderate to high doses of LSD can reduce anxiety, pain, and depression in 60 adults with advanced, life-limiting illnesses (life expectancy 12 weeks to 2 years). Participants receive either two doses of LSD or a very low active placebo, and researchers me…

This study tests whether cannabidiol (CBD) suppositories can reduce pain during sex and improve overall well-being. Fifty adults who experience sexual pain will use different doses of CBD suppositories for one month, with a follow-up after 12 weeks. The goal is to see if this app…

This study aims to see if adding two weekly check-in phone calls to standard cognitive behavioral therapy (CBT) improves quality of life for adults living in rural Texas. Researchers will compare CBT alone to CBT plus the extra calls in 60 participants. The goal is to find a simp…

This study looks at whether adding Brandt-Daroff exercises to the standard GANS maneuver can better reduce dizziness and improve quality of life in people with BPPV, a common inner ear condition that causes brief spinning sensations. Researchers will compare the GANS maneuver alo…

This study tests a mobile app called Stappvoorstap for adults waiting for mental health treatment in the Netherlands. The app helps users track daily stress, learn coping skills, and do relaxation exercises. Over 4 weeks, researchers will measure changes in stress, coping confide…

This study tests a free 6-week online coaching program for NSU undergraduate students. The program aims to reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the study measures changes using standard …

This study tests whether a 12-week digital yoga program called MediYoga can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get online support. The goal is to see if this…

This study tests whether drinking Jing Si Herbal Tea twice a day can improve quality of life and sleep for people with dementia and their caregivers. Researchers will compare the tea against a placebo in 400 participants over six months. The goal is to see if this simple, natural…

This study tests a coaching program for pregnant or new-mom doctors to see if it reduces burnout and improves well-being. About 48 residents or fellows will be randomly assigned to receive coaching or not. The program includes one-on-one and group coaching sessions over 4 months,…

This study looks at whether extending the nightly fasting period (not eating for a longer stretch each night) can help breast cancer survivors who have trouble with sleep and thinking clearly. Researchers will compare a fasting program to a health education program in 60 female s…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help women with endometrial or cervical cancer use fewer opioid painkillers and feel better. About 120 participants will be randomly assigned to use the app or not. The goal is to…

This study is testing a smartphone app that uses artificial intelligence to help people with oral cancer recover and return to work. The app provides personalized support for physical symptoms, emotional distress, and communication challenges. Researchers will compare 650 patient…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to relieve severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see which method …

This study follows 160 men with good-prognosis metastatic testicular cancer to compare side effects of two treatments: surgery (RPLND) or chemotherapy. Researchers want to know which approach causes less fatigue and better overall quality of life. Participants choose their treatm…

This study is for people aged 60 or older having hip replacement surgery. It compares two doses of a steroid called dexamethasone given during surgery to see if it helps with pain, fatigue, and overall recovery. The goal is to find out if a higher dose improves quality of life up…

This study tests whether a 24-week Frame Running training program can improve physical function, daily activity, and quality of life in children aged 8-18 with cerebral palsy or other physical disabilities. Participants start with a low-intensity 12-week period, then move to a hi…

This study looks at whether taking a collagen supplement for 8 days can improve quality of life, appetite, and blood sugar control in overweight or obese adults aged 18 to 65. Participants will take the supplement or a placebo, fill out questionnaires about their mood and energy,…

This study tests three different hand therapies—mirror therapy, brain stimulation (rTMS), and robotic hand training—added to standard rehab for stroke survivors. The goal is to see which approach best improves arm movement, reduces pain, and boosts quality of life. About 120 adul…

This study tests a program called CAPABLE Transplant to help people with kidney failure who are waiting for a transplant. The program addresses barriers like frailty, depression, and lack of support to help them become active on the waitlist. About 43 low-income adults will parti…

This study tests whether a tailored physical activity program helps preserve exercise capacity, heart function, memory, and quality of life in adults with lymphoma or breast cancer undergoing treatment. About 110 participants will be randomly assigned to either health education w…

This study compares two types of exercise training—Dynamic Neuromuscular Stabilization (DNS) and Pelvic Floor Muscle Training (PFMT)—in women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 51 women will be randomly assigned to one o…

This study tests if a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. About 106 survivors with thinking, mood, or social problems will use a web app designed to support their recovery. The goal is to see if this easy-to…

This study tests whether a program called CAPABLE can be added to home-based primary care to help older adults who feel lonely or isolated. The program focuses on improving daily activities, reducing pain, and easing depression. Researchers will enroll 450 homebound older adults …

This study compares underwater exercise to regular aerobic exercise in 100 adults with muscle weakness and low quality of life. Participants will be assigned to one of the two exercise programs. The goal is to see which approach better improves muscle power, reduces pain, and enh…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other discomforts. About 80 postmenopausal women will apply the gel for 8 weeks. Researchers will use a questionnaire to measure changes in sy…

This study tests a modified double-J ureteral stent designed to reduce common side effects like pain, blood in urine, and discomfort when urinating. About 40 adults with kidney or ureteral stones will receive either the new stent or a standard one. Researchers will measure how th…

This study is testing whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help Black teenagers and young adults with sickle cell disease cope with stress related to racism. About 30 participants aged 14–21 will attend 10 group therapy sessions as par…

This study looks at whether a special drink made from fermented whey and fiber can help recreational athletes feel better in their stomach. Researchers will test it in two groups: athletes without stomach issues and those who often have digestive problems. The goal is to see if t…

This study looks at children with congenital melanocytic nevi (CMN), a type of birthmark, to see if surgical removal improves their quality of life and reduces feelings of being stigmatized. About 100 children aged 9 months to 16 years will be followed before and after surgery. T…

This study is testing whether regular, friendly phone calls from trained volunteers can help reduce loneliness, depression, and thoughts of suicide in older adults who are homebound. About 400 people aged 65 and older who receive home-delivered meals or other community services w…

This study compares two different hormone treatments used to prepare the ovaries for egg retrieval in IVF. The goal is to see which method patients find more tolerable and satisfying. About 60 women undergoing fertility preservation or genetic testing will try both methods and re…

This study tests if trauma-adapted yoga, added to usual care, can improve mental health and quality of life in 180 teens diagnosed with ADHD or PTSD. Participants will be randomly assigned to a yoga group or a waiting list. The goal is to see if yoga reduces symptoms like inatten…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health and quality of life in women waiting for IVF treatment. 120 women with at least mild anxiety, stress, or depression will be randomly assigned to receive lavender oil, a placebo, or n…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain education, can reduce migraine-related disability and improve sensory and muscle function in women aged 18 to 48 with migraine. One hundred participants will be randomly ass…

This study looks at whether a non-invasive radiation treatment called stereotactic radiosurgery can improve quality of life and reduce shaking in people with essential tremor or Parkinson's tremor. About 60 adults whose tremors are not well controlled by medication will be follow…

This study looks at quality of life in women aged 65 and older with low-risk breast cancer after a lumpectomy. Participants will receive either a short course of radiation or hormone therapy for five years. The goal is to see which treatment leads to better daily well-being while…

This study looks at how a health and wellness product affects digestion and quality of life in 133 adults, including those taking GLP-1 medications for weight loss. Participants will complete surveys and provide samples to track changes in gut health and related symptoms. The goa…

This study looks at whether dry needling—a treatment where thin needles are inserted into muscles—can help people with chronic low back pain feel better and improve their quality of life. Researchers will test three different needling sessions in 42 adults, including healthy volu…

This study looks at whether combining pain education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women with endometriosis will take part. The goal is to see if this approach helps …

This study compares early pain after two types of weight-loss surgery: robotic sleeve gastrectomy and laparoscopic sleeve gastrectomy. About 91 adults eligible for sleeve gastrectomy will be randomly assigned to one of the two procedures. The main goal is to see if robotic surger…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in veterans aged 60 and older who have both COPD and obstructive sleep apnea (called overlap syndrome). About 668 participants will use PAP th…

This study looks at how getting a full set of fixed dental implants changes people's daily lives and happiness. Researchers will ask 100 adults with no teeth how their oral health affects their well-being before and after treatment. The goal is to understand the real-world benefi…

This study tests a special gel and mouthwash (XCM-OM118) in 63 head and neck cancer patients getting radiation, with or without chemo. The goal is to see if it lowers the chance of severe mouth sores and improves quality of life. Patients use the product during radiation and late…

This study tests a new rehabilitation program that uses multiple senses (like hearing and touch) to help people with ultra low vision. The goal is to improve visual ability, hand-eye coordination, and quality of life. The program is designed for people whose vision is 20/1600 or …

This study is testing whether a special snack rich in plant nutrients and fiber can improve common menopause symptoms like hot flashes, night sweats, mood changes, and sleep problems. About 20 women aged 40-55 who are not on hormone therapy will eat the snack or a placebo daily f…

This study compares four mouthwashes (Bone Bioactive Liquid, Hyaluronic Acid, Chlorhexidine, and Warm Saline) to see which one helps the healing of wisdom tooth extraction sockets. One hundred adults who need a lower wisdom tooth removed will be randomly assigned to use one of th…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical and mental health in women veterans aged 18-45. Participants will play VR games that involve physical movement, and researchers will measure changes in depression, anxiety, PTSD, …

This study is testing whether a pulmonary rehabilitation program can help people with advanced non-small-cell lung cancer maintain muscle mass, improve lung function, and reduce inflammation. About 94 participants will take part while receiving standard cancer treatments like che…

This study tests whether a minimally invasive procedure called alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18–45 with ovarian endometriomas. Participants are randomly assigned to receive the procedure or no treatment (expectant managemen…

This study tests a 12-week wellness program for 50 residents of a transitional housing estate in Hong Kong. Participants will do light exercise, gardening, and attend health talks to see if it improves their quality of life, happiness, and daily activities. The program is designe…

This study tests a new digital follow-up program for people who have had early-stage colorectal cancer. The program uses a smartphone app to monitor symptoms, fear of cancer returning, and quality of life, and provides personalized care. About 400 participants will be split into …

This study tests a special support program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The goal is to see if this program can improve quality of life and reduce depression compared to usual care. The study will involve 120 women and …

This study tests whether a non-invasive technique called transcranial magnetic stimulation (TMS) can help people recover movement after brain tumor surgery. Six adults with lasting motor problems will receive TMS once a day for three days. Researchers will measure muscle strength…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests a device called Patient-Controlled Transcutaneous Electrical Acupoint Stimulation (PC-TEAS) to see if it can improve quality of life for people with long-term cancer pain. About 290 adults with cancer pain will use the device at home as needed. Researchers will m…

This study looks at whether adding kinesiotaping (a special tape) to prenatal stretching exercises can reduce low back pain, improve movement, and enhance quality of life in pregnant women. About 34 women between 20-34 weeks of pregnancy and aged 18-35 will take part. Participant…

This study looks at whether a structured exercise program can help recreational video game players react faster and click more accurately. Researchers will measure changes in reaction time and mouse accuracy in 15 college students who play at least one hour of video games per wee…

This study looks at whether using a handheld breathing device (oscillating PEP) helps children (ages 8+) and adults with bronchiectasis feel better day-to-day. Researchers will ask 60 participants about their quality of life before and after using the device. The goal is to see i…

This study looks at whether combining Swiss ball exercises with deep breathing can reduce stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) in pregnant women. About 42 pregnant women with mild to moderate leakage will be split into two groups: one…

This study looks at whether hearing aids can improve the quality of life for cancer patients who develop hearing problems from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing loss will be offered a hearing aid. Researche…

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, combined with practical heat-safety advice, can reduce heat-related illnesses and improve quality of life. Over 7,000 people in low-income neighborhoods of Karachi, Pakist…

This study follows 200 adults with advanced cancer who are receiving immunotherapy at home. Researchers will track their physical and emotional distress, financial strain, care needs, and quality of life over one year. The goal is to develop a risk prediction model to identify pa…

This study tests whether a digital dashboard can help home visitors deliver better mental health and parenting support to families in Rwanda. About 1,800 participants, including caregivers and government officials, will use the tool to track progress and access training materials…

This study translates a questionnaire that measures the impact of involuntary movements (dyskinesia) on daily life in Parkinson's disease into Turkish. Researchers will test the translated version in 130 people with Parkinson's to ensure it is accurate and reliable. The goal is t…

This study is for women who have had the first stage of implant-based breast reconstruction and have surgical drains in place. The goal is to see if showering 48 hours after drain placement increases the risk of infection or affects quality of life. About 100 participants will be…

This study surveys 400 men undergoing ICSI treatment due to low sperm quality. Researchers want to understand their emotional experiences, social burden, and testosterone levels, and compare them to a similar study from 2008. The goal is to see if men's needs and feelings have ch…

This study looks at how small fiber neuropathy (nerve damage causing pain, numbness, and tingling) impacts the quality of life and medical costs for people with Sjögren's syndrome, an autoimmune disease. Researchers will follow 100 adults with Sjögren's to measure their symptoms,…

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, along with practical heat-safety advice, can reduce heat-related illnesses and improve quality of life. Over 7,000 people in rural Pakistani villages will participate, wit…

This study follows 250 people with chronic diverticular disease to see if elective surgery improves their quality of life compared to non-surgical care. Participants will fill out questionnaires about symptoms, bowel function, and overall well-being. The goal is to help doctors a…

This study follows 1500 women for 5 years after breast cancer surgery to understand how their quality of life changes. Participants fill out simple questionnaires about their physical and emotional well-being. No new treatments are tested—the goal is to learn what matters most to…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation machine. The goal is to collect data on survival, tumor control, side effects, and …

This study tests whether an 8-week online program based on logotherapy (finding meaning) can help middle-aged office workers become more active and improve their quality of life. About 200 participants aged 35-60 with desk jobs will be split into two groups: one gets the program,…

This study explores the link between mental health and symptom severity in people with graft-versus-host disease (GvHD), a complication after bone marrow transplant. Researchers will assess depression, anxiety, and quality of life in 200 adults. The goal is to understand if treat…

This study follows 100 people whose pilonidal cyst came back after either surgery or laser treatment. Researchers will use questionnaires to measure how the recurrence impacts quality of life, pain, and daily activities. The goal is to better understand the real-world burden of t…

This study follows 327 adults aged 65 and older who have surgery for gastrointestinal cancer. Researchers want to find out what factors predict a decline in their daily function and quality of life one year later, and how their cancer outcomes look after five years. The goal is t…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep problems. Researchers will track how insomnia develops over the first year, what factors like treatments or emotions contribute, and whether patients get help from sleep specialists. The goal is to …

This study follows children (aged 16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to check if these children have higher risks for heart or kidney problems due to the mother's transplant and medications. Participants will have a one-tim…

This study looks at whether using a smartphone app to fill out recovery surveys after hip replacement is as good as the traditional paper method. About 50 adults having hip surgery will be asked to complete questionnaires on their phone or on paper. The goal is to see if people a…

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their own healthcare. The app includes a digital medical passport, educational information, community suppor…

This study looks at whether providing meal kits and nutrition education can improve food security, diet quality, mental health, and heart health in adults aged 40 and older with low income. About 120 participants will be split into two groups: one gets meal kits and classes, the …

This study looks at how sleep problems impact thinking skills and quality of life in women treated for breast cancer. About 75 participants aged 39 to 69 will have their sleep measured with special devices and answer questionnaires. The goal is to understand these links and find …

This study looks at how stroke survivors' arm muscles respond when they imagine moving or watch someone else move. Researchers at the University of Salamanca will measure muscle activity in the wrist and fingers during these tasks. The goal is to understand which mental technique…

This study looks at how a brief full-body cold-water bath changes the way people make decisions, their mood, and body signals like heart rate and stress hormones. Forty healthy adults aged 18-40 will take both a cold and a warm bath on different days, then complete tasks and surv…

This study looks at how women's views on artificial intelligence relate to their anxiety levels and quality of life while going through infertility treatment. About 191 women aged 18-45 who are currently receiving treatment will answer questionnaires. The goal is to understand if…

This study follows 800 adults who spent at least 48 hours in the ICU to track how many develop ongoing pain. Researchers will call participants at 90 and 180 days after leaving the ICU to ask about pain, sleep, mood, and quality of life. A smaller group will also have a detailed …

This study looks at how inner strengths like resilience, gratitude, and acceptance help older adults (60+) feel better and cope with stress. Researchers will measure quality of life, loneliness, and emotional well-being in 110 participants living in Spain. The goal is to shift th…

This study is collecting blood samples from 5000 people having heart, colorectal, vascular, or lung surgery to find biological markers that can predict serious complications like infections, kidney injury, or death within 30 days. The goal is to improve risk assessment and guide …

This study looks at what makes life better for people aged 60 and older living in nursing homes in Hanoi, Vietnam. Researchers will interview 176 residents to see how things like health, independence, and support from others affect their quality of life. The goal is to use this i…

This study is translating and testing a quality-of-life questionnaire (AQUAREL) for Turkish-speaking people with pacemakers or similar heart devices. Researchers will enroll 120 patients to check if the Turkish version is accurate and reliable. The goal is to give doctors a bette…

This study looks at how well a heart procedure called catheter ablation improves quality of life for people with a fast heart rhythm (ventricular tachycardia) who also have an implantable defibrillator. Researchers will ask 70 adults to fill out questionnaires about their health …

This study looks at how immunotherapy for advanced cancer changes a person's physical fitness and quality of life. About 67 adults with solid tumors will take fitness tests and answer questionnaires before starting treatment and again 12 weeks later. Researchers will also track l…

This study looks at how nerve pain (neuropathic pain) affects the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain levels and quality of life in 128 adults using standard questionnaires. No new treatments are te…

This study looks at how the daily independence of young children with rare genetic disorders affects their families' mental health and quality of life. Researchers will assess 45 children aged 0-4 and their caregivers using questionnaires. The goal is to help doctors provide bett…

This study follows 632 women who received Silimed breast implants (textured or polyurethane-coated) for augmentation. Researchers will track side effects and patient satisfaction over 10 years. The goal is to better understand the long-term risks and how happy women are with thei…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …