QUALITY OF LIFE

This study tests whether spermidine, a natural substance found in foods like wheat germ and soy, can improve heart and muscle health in older adults with coronary artery disease. About 180 participants aged 65 and older will receive either spermidine or a placebo for a period, an…

This study is testing a new, simpler laparoscopic surgery for women with pelvic organ prolapse (when pelvic organs drop from their normal position). The goal is to restore anatomy and improve quality of life while reducing risks from surgical mesh. About 60 women aged 30-80 with …

This study tests whether injecting special stem-like cells called Muse cells directly into the ovaries can help women aged 28 to 70 going through perimenopause. The goal is to see if the treatment can stabilize hormones, reduce symptoms like hot flashes and mood changes, and impr…

This study looks at whether a planned two-step procedure is safer and more effective than a single long procedure for people with completely blocked heart arteries (chronic total occlusion). About 200 participants will be treated with a first procedure to prepare the blockage, fo…

This study tests a special program called Horizons for adults who have had a stem cell transplant and developed chronic graft-versus-host disease (GVHD). The program includes counseling and support to help patients manage their symptoms, reduce stress, and take their medications …

This study tests whether a 12-week physical exercise program can improve quality of life and daily function in people who have had heart surgery, such as valve replacement or bypass. About 76 participants will be assigned to either the exercise program or standard care, and their…

This study was designed to see if a food supplement called ARACOMPLEX® could help maintain or improve quality of life in people with advanced pancreatic cancer who are also receiving chemotherapy. The supplement contains maca extract, vitamins, and minerals. The study planned to …

This study tests whether a group-based program called Horizons can improve quality of life and coping skills in adults with chronic graft-versus-host disease (cGVHD), a complication after stem cell transplant. About 20 participants will attend 8 group sessions. The main goal is t…

This study tests an online self-help program, Together After Cancer, for breast cancer survivors and their intimate partners. About 480 couples will be randomly assigned to the program or usual care. The goal is to see if the program improves the survivor's quality of life and th…

This study compares two weight-loss surgeries—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—in 200 adults with obesity. The goal is to see which approach leads to fewer digestive problems (dumping syndrome) and better quality of life six months after…

This study looks at whether a regular, 8-week exercise program can improve physical fitness and quality of life for paramedic students. About 60 students will be randomly assigned to either the exercise group or a control group. Researchers will measure changes in endurance, stre…

This study tests a program called Bright IDEAS that teaches problem-solving skills to parents of children receiving palliative care. The goal is to see if it helps reduce parents' anxiety, depression, and stress compared to standard support. About 40 parents will take part in 6-8…

This study looks at whether giving more blood transfusions to anemic patients after they leave the intensive care unit (ICU) can help them feel less tired and improve their quality of life. About 346 adults who are ready to leave the ICU and have low hemoglobin will be randomly a…

This study gives 250 advanced cancer patients $1,000 each month for a year to see if it eases financial stress and improves their quality of life. Participants complete surveys every three months and some share their experiences in interviews. The goal is to learn whether extra i…

This study compares two treatments for early-stage throat cancer: robotic surgery (TORS) or radiation therapy (IMRT). It looks at which one leads to better swallowing function and overall quality of life. About 138 adults with HPV-related throat cancer are taking part. The goal i…

This study tests whether watching 10-minute virtual reality nature videos twice a week for 12 weeks can improve quality of life and mood in nursing home residents with dementia. Sixty participants will either receive the virtual nature sessions plus usual care, or just usual care…

This study tests whether an 8-week mobile app program, combined with phone counseling, can reduce the severity of urinary incontinence and improve quality of life and sleep in menopausal women. 82 women aged 40-65 with bladder control issues are split into two groups: one gets th…

This study aimed to see if practicing mindfulness breathing exercises could improve heart rate, blood pressure, metabolism, and quality of life in adults with spinal cord injury. It planned to enroll people aged 18-70 with injuries from C5 to T10. However, the study was withdrawn…

This study tests whether focused ultrasound (MR-HIFU), alone or with standard radiation, can better relieve pain from cancer that has spread to the bones. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to see if adding ult…

This study aims to see if exercise can help children aged 8-18 with acute lymphoblastic leukemia (ALL) who are on maintenance chemotherapy feel better and be more active. Researchers will measure quality of life, physical activity, sleep, and fatigue. The goal is to find simple w…

This study tests a 12-week program called Breathe Easier+ for people who have finished treatment for non-small cell lung cancer and their partners. The program includes guided walking, strength training, and meditation delivered remotely via tablet or smartphone. The goal is to s…

This study aimed to see if trazodone, a sleep aid, works better than quetiapine (an antipsychotic) or a placebo for treating delirium in adult surgical ICU patients. Delirium causes confusion, agitation, and sleep problems. The trial planned to measure how long delirium lasts, sl…

This study aimed to see if the Sana device could improve quality of life and reduce pain in people with fibromyalgia. It planned to compare the active device to a sham (fake) device in about 100 adults aged 18 to 65 who had fibromyalgia symptoms for at least 3 years. However, the…

This study aimed to see if using an immersive virtual reality headset for balance exercises is safe and practical for people with multiple sclerosis who experience dizziness and fatigue. The researchers planned to compare this new approach to standard vestibular therapy. However,…

This study looks at whether a special education program before gallbladder removal surgery can improve patients' quality of life after the operation. About 200 adults aged 18 to 75 will take part. One group will get the usual hospital instructions, while the other will attend ext…

This study looks at whether a mobile app called Horizons can help adults who have chronic graft-versus-host disease after a stem cell transplant. About 20 people will use the app and answer surveys to see if it is practical and helpful. The goal is to improve their quality of lif…

This study looks at whether special movement exercises (perceptual-motor training) can help children with ADHD think better, move better, and feel better day-to-day. Thirty children aged 8 to 12 will take part. The goal is to see if these exercises improve cognitive functions, mo…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, calmness training, healthy lifestyle advice, and parent support groups to improve quality of life for both kids and their families. About 100 children and their parents will take part …

This study looks at whether recreational group drumming can improve the health of older adults living in the community. Researchers will measure changes in quality of life, depression, sleep, and blood pressure in 300 participants aged 60 and above. The goal is to see if drumming…

This study looks at whether teaching people how to care for their mouth and teeth can improve oral health, sleep, and overall quality of life for those using a non-invasive breathing machine at home. About 30 adults will be split into two groups: one gets special oral care educat…

This study looks at whether a 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more in control during their radiation treatment. About 109 patients will be randomly assigned to either receive this extra session or standa…

This study tests a video game designed to teach self-advocacy skills to women with advanced cancer. The game lets players make decisions for characters facing similar challenges, helping them learn to communicate better with doctors and manage symptoms. The goal is to improve qua…

This study tests a smartphone platform that uses artificial intelligence to help liver transplant patients manage their health after surgery. Researchers will track self-care, confidence, and quality of life in 133 adults over one year. The goal is to see if the platform reduces …

This study tests a home-based digital literacy program for adults aged 65 and older. The goal is to see if improving tech skills can boost health communication, social support, and quality of life. Twenty participants will learn to use digital tools to better manage their health …

This study looks at whether adding community health worker visits and healthy grocery bags to the standard Meals on Wheels program can improve diet, reduce loneliness, and enhance quality of life for older adults at nutritional risk. About 1,640 participants in Rhode Island will …

This study looks at whether stereotactic radiosurgery (a precise type of radiation) for brain tumors causes problems with thinking, memory, or quality of life. About 80 adults with brain metastases or meningiomas will take memory tests and fill out questionnaires before and after…

This study compares two surgical methods for right-sided colon cancer: open surgery and laparoscopic (keyhole) surgery. The goal is to see which approach leads to less pain, fewer complications, and a faster recovery, while still being equally effective at removing the cancer. Re…

This study looks at how tiredness (fatigue) affects the daily activities and quality of life of 89 children aged 2 to 18 who are being treated for cancer. Researchers will use special questionnaires to measure fatigue and how well the children can do everyday tasks. The goal is t…

This study follows 90 people who survived severe COVID-19 pneumonia in the ICU to understand their long-term physical and mental health. Researchers will check lung function, quality of life, and psychological well-being at 3 months, 6 months, 1 year, and 5 years after leaving th…

This study tests a web-based decision aid and planning tool for female cancer survivors who want to have children in the future. The tool helps them make informed choices about family building after cancer treatment. Researchers will measure how the tool affects decision-making a…

This study is collecting data from up to 300,000 adults who use a digital physical activity program called Sword Move. The goal is to observe how increasing physical activity affects overall health, well-being, and mental health. Participants are healthy or have stable conditions…

This study follows 300 adults in the Bonton neighborhood to see how taking part in community wellness programs (like healthy eating and exercise activities) affects their heart health and quality of life over one year. Participants choose which activities to join, and researchers…

This study looks at 150 adults having their thyroid gland removed. Doctors will use a rapid hormone test during surgery to tell who is at high or low risk for a common complication that causes low calcium levels. Depending on the result, patients will either skip routine blood te…

This study interviews 20 people aged 16-25 who have had urinary problems since childhood and are moving from pediatric to adult urology care. The goal is to learn about their experiences and challenges during this transition. Findings will help doctors improve care for other youn…

This study looks at how invasive breast cancer and its treatments impact the quality of life of 133 patients in Martinique. Researchers will use surveys to understand patients' physical, emotional, and daily challenges, as well as how long treatment takes. The goal is to find way…

This study follows 384 adults in Brazil who are using cannabis-based products prescribed by their doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients for 6 months through online surveys to measure changes in qualit…

This study looks at how spasmodic dysphonia, a condition that causes uncontrollable voice spasms, affects patients' jobs and social lives. Researchers will interview 20 adults who have received botulinum toxin injections to understand the condition's impact and whether treatment …

This study tests whether proactive telemedicine (brief remote coaching on habits like smoking, diet, and exercise) works as well as in-person visits for rural adults who haven't seen their primary care team in over a year. About 120 participants will be randomly assigned to eithe…