Could a drug combo during surgery speed up recovery?

NCT ID NCT06884540

Ongoing Symptom relief Sponsor: CHU de Quebec-Universite Laval Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 02, 2026 · Updated 4 times

Summary

This pilot study tests whether giving dexmedetomidine and lidocaine during major non-cardiac surgery can help patients recover faster and with less pain. About 100 adults having elective surgery will be randomly assigned to receive one of these drugs or standard care. The main goal is to see if a larger trial is possible, not yet to prove the drugs work.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexmedetomidine and lidocaine
What this could lead to: If this works, it could lead to a simple way to improve recovery after major surgery and reduce reliance on opioids.
What could go wrong: This is a small pilot study testing feasibility, not effectiveness. The drugs may not improve outcomes or could cause side effects like low blood pressure.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIA ANESTHESIA COMPLICATION ANESTHESIA MORBIDITY FEASIBILITY STUDIES PAIN, POSTOPERATIVE PATIENT-CENTREDNESS QUALITY OF LIFE SURGERY

Contacts and locations

Locations

CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus)

Québec, Quebec, G1J 1Z4, Canada
CISSS de Chaudière-Appalaches (Hôtel-Dieu de Lévis)

Lévis, Quebec, G6V3Z1, Canada
Centre hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, H2X 0C1, Canada
Mount Sinai Hospital

Toronto, Ontario, M5G 1X5, Canada
Royal Columbian Hospital

New Westminster, British Columbia, V3L 0A2, Canada

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