Experimental virus therapy VAXINIA tested in advanced cancer patients

NCT ID NCT05346484

Terminated Disease control Sponsor: Imugene Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tested a new treatment called VAXINIA (CF33-hNIS), a virus designed to attack cancer cells, in 66 adults with advanced solid tumors that had spread. The treatment was given alone or with the immunotherapy drug pembrolizumab, either as a shot into the tumor or through a vein. The main goal was to check safety and find the best dose, but the study was stopped early.

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Conditions

The condition(s) this trial relates to.

bile duct cancer bile duct neoplasm carcinoma cholangiocarcinoma metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR BILE DUCT CANCER CHOLANGIOCARCINOMA METASTATIC CANCER SOLID CARCINOMA SOLID TUMOR SOLID TUMOR, ADULT

Contacts and locations

Locations

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
City of Hope Medical Center

Duarte, California, 91010, United States
Corewell Health

Grand Rapids, Michigan, 49503, United States
Highlands Oncology

Springdale, Arkansas, 72762, United States
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
NEXT Oncology

Fairfax, Virginia, 22031, United States
St. Vincent's Hospital

Fitzroy, Victoria, 3065, Australia
Tasman Oncology Research

Southport, Queensland, 4215, Australia
UC San Diego Moores Cancer Center

La Jolla, California, 92093-0698, United States
University of Arizona Cancer Center

Tucson, Arizona, 85724-5024, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Miami

Miami, Florida, 33136, United States

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