Cancer cocktail trial halted early – what went wrong?
NCT ID NCT02959437
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a combination of three drugs (azacitidine, pembrolizumab, and epacadostat) in 70 people with advanced solid tumors, including lung and colorectal cancers. The goal was to see if the combination was safe and could shrink tumors. However, the trial was terminated early, meaning the results are incomplete and no clear conclusions can be drawn about its effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
azacitidine, pembrolizumab, and epacadostat
What this could lead to
If successful, this combination might offer a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
What could go wrong
The trial was terminated early, so results are limited. The combination may cause significant side effects, and it is unclear if it works better than existing treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Churchill Hospital
Oxford, Ox37le, United Kingdom
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City of Hope National Medical Center
Duarte, California, 91010, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Sarah Cannon
Nashville, Tennessee, 37203, United States
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The University of Chicago
Chicago, Illinois, 60637, United States
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Univ De Navarra
Pamplona, 31008, Spain
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University College London Hospitals (Uclh)
London, W1t7ha, United Kingdom
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University of California San Diego
La Jolla, California, 92093, United States
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University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19014, United States
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University of Washington
Seattle, Washington, 98109, United States
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Vall D Hebron Univ
Barcelona, 08035, Spain
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States