New imaging agent could sharpen view of HER2 cancers

NCT ID NCT06828588

First seen Oct 31, 2025

Summary

This early-phase study tests a radioactive tracer called [68Ga]Ga-ABY-025 for PET scans in 30 adults with advanced HER2-positive cancers (breast, stomach, head/neck, esophageal). Participants receive the tracer and a PET/CT scan while on standard HER2-targeted therapy. The main goal is to check safety and see if the tracer helps identify tumors better than current methods.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

[68Ga]Ga-ABY-025 (a radioactive tracer for PET scans)

What this could lead to

If successful, this imaging method could help doctors more accurately spot HER2-positive tumors and monitor treatment response.

What could go wrong

This is a very early, small pilot study (30 people) focused on safety and imaging, not treatment. It may not lead to better outcomes or work for all patients.

Conditions

The condition(s) this trial relates to.

breast neoplasm esophageal squamous cell carcinoma gastric neoplasm head and neck squamous cell carcinoma HER2 positive breast carcinoma metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.