HER2
Clinical trials for HER2 explained in plain language.
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New pill takes on hard-to-treat HER2 cancers, including brain tumors
Disease control Recruiting nowThis early-phase trial tests an experimental drug called IAM1363 in people with advanced cancers that have HER2 alterations. The study aims to find a safe dose and see if the drug can shrink tumors, including those that have spread to the brain. About 383 adults whose cancer has …
Matched conditions: HER2
Phase: PHASE1 • Sponsor: Iambic Therapeutics, Inc • Aim: Disease control
Last updated May 17, 2026 03:26 UTC
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New pill takes aim at hard-to-treat cancers with HER2 mutations
Disease control Recruiting nowThis early-phase study tests a new oral drug, CGT4255, in about 100 adults whose advanced solid tumors have certain genetic changes (ERBB2 alterations or HER2 overexpression). The main goals are to check the drug's safety, find the best dose, and see if it shrinks tumors, includi…
Matched conditions: HER2
Phase: PHASE1 • Sponsor: Cogent Biosciences, Inc. • Aim: Disease control
Last updated May 12, 2026 13:41 UTC
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New hope for hard-to-treat cancers: triple therapy targets HER2-positive tumors
Disease control Recruiting nowThis study tests a combination of two targeted drugs (trastuzumab and serplulimab) plus chemotherapy in 20 adults with advanced bile duct or bladder cancers that have stopped responding to standard treatments. The goal is to see if this triple therapy can shrink tumors and improv…
Matched conditions: HER2
Phase: PHASE2 • Sponsor: Xiujuan Qu • Aim: Disease control
Last updated May 11, 2026 20:48 UTC
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New hope for hard-to-treat ovarian cancer: targeted drug combo shows promise
Disease control Recruiting nowThis study tests a new drug (distamab vedotin) combined with carboplatin for people with advanced ovarian cancer that has a specific protein called HER2. The goal is to see if this combination works better and has fewer side effects than standard chemotherapy. About 20 participan…
Matched conditions: HER2
Phase: PHASE2 • Sponsor: Zhejiang Cancer Hospital • Aim: Disease control
Last updated May 11, 2026 20:40 UTC
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New PET tracer could sharpen view of HER2 cancers
Diagnosis Recruiting nowThis early study tests whether a special radioactive tracer called [68Ga]Ga-ABY-025 can improve PET scans to find HER2-positive tumors in people with advanced breast, stomach, head and neck, or esophageal cancers. About 30 adults already receiving standard HER2-targeted therapy w…
Matched conditions: HER2
Phase: EARLY_PHASE1 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Diagnosis
Last updated May 17, 2026 03:31 UTC
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Italian study maps rare HER2 mutations in advanced lung cancer
Knowledge-focused Recruiting nowThis study looks at how often HER2 gene changes occur in people with advanced non-small cell lung cancer (NSCLC) in Italy, and how doctors currently treat these cases. About 50 adults with advanced NSCLC will be observed for one year. The goal is to gather information, not to tes…
Matched conditions: HER2
Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica • Aim: Knowledge-focused
Last updated May 17, 2026 03:19 UTC