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Experimental combo targets Hard-to-Treat cancers

NCT ID NCT03994601

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested an experimental drug called BMS-986288, both by itself and combined with the immunotherapy nivolumab (Opdivo), in 219 people with advanced solid tumors that had worsened after standard treatments. The main goal was to check safety and tolerability, and to find the right dose. The study is now complete, but results are not yet available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BMS-986288 (an experimental drug) and nivolumab (Opdivo, an immunotherapy)

What this could lead to

If successful, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.

What could go wrong

This is an early-phase trial focused on safety, so it is not yet known if the drug combination works. Side effects could be serious, and the results may not lead to a widely available treatment.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CANCER

Contacts and locations

Locations

  • Centre Hospitalier intercommunal de Toulon La Seyne sur Mer

    Toulon, 83100, France

  • Local Institution - 0001

    Hackensack, New Jersey, 07601, United States

  • Local Institution - 0002

    Baltimore, Maryland, 21287, United States

  • Local Institution - 0004

    St Louis, Missouri, 63110, United States

  • Local Institution - 0005

    Aurora, Colorado, 80045, United States

  • Local Institution - 0006

    Toronto, Ontario, M5G 2M9, Canada

  • Local Institution - 0008

    ABB, Distrito Federal, C1199, Argentina

  • Local Institution - 0009

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Local Institution - 0010

    Viña del Mar, Valparaiso, 2520598, Chile

  • Local Institution - 0011

    Ciudad Autónoma de Buenos Aires, Buenos Aires, 1426, Argentina

  • Local Institution - 0012

    CABA, Distrito Federal, C1430, Argentina

  • Local Institution - 0013

    Río Cuarto, Córdoba Province, 5800, Argentina

  • Local Institution - 0014

    Córdoba, Córdoba Province, X5000HXL, Argentina

  • Local Institution - 0015

    Paris, 75248, France

  • Local Institution - 0016

    Buenos Aires, C1280AEB, Argentina

  • Local Institution - 0017

    Buenos Aires, 1431, Argentina

  • Local Institution - 0018

    Bron, 69677, France

  • Local Institution - 0019

    Santiago, Santiago Metropolitan, 7510032, Chile

  • Local Institution - 0022

    Saint-Herblain, Loire-Atlantique, 44800, France

  • Local Institution - 0023

    Madrid, 28041, Spain

  • Local Institution - 0024

    Majadahonda, 28222, Spain

  • Local Institution - 0025

    Valencia, 46026, Spain

  • Local Institution - 0026

    Marseille, 13915, France

  • Local Institution - 0028

    Ancona, 60126, Italy

  • Local Institution - 0031

    Milan, 20162, Italy

  • Local Institution - 0033

    Catanzaro, 88100, Italy

  • Local Institution - 0034

    Bordeaux, Gironde, 33075, France

  • Local Institution - 0035

    Santiago, Santiago Metropolitan, 7620002, Chile

  • Local Institution - 0036

    Santiago, Santiago Metropolitan, 7500921, Chile

  • Local Institution - 0038

    Padova, Veneto, 35128, Italy

  • Local Institution - 0039

    Roma, 00168, Italy

  • Local Institution - 0040

    Milan, Lombardy, 20133, Italy

  • Local Institution - 0042

    Montreal, Quebec, H2X 0A9, Canada

  • Local Institution - 0046

    Montreal, Quebec, H3T 1E2, Canada

  • Local Institution - 0050

    Orange, California, 92868-3201, United States

  • Local Institution - 0054

    Barcelona, Catalunya [Cataluña], 08036, Spain

  • Local Institution - 0055

    Seville, 41013, Spain

  • Local Institution - 0056

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Local Institution - 0074

    Buenos Aires, Buenos Aires F.D., C1096AAS, Argentina

  • Local Institution - 0075

    Costa Mesa, California, 92627, United States