Can a quick zap after liver surgery keep cancer away?

NCT ID NCT05492136

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether applying a radiofrequency device to the cut surface of the liver after tumor removal can reduce the chance of cancer returning at that spot. About 720 adults with liver cancer (either colorectal metastases or hepatocellular carcinoma) will be randomly assigned to receive either standard surgery or surgery plus this extra coagulation step. The main goal is to see if local recurrence rates are lower in the group that gets the extra treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

radiofrequency coagulation procedure

What this could lead to

If successful, this could provide a simple, low-cost way to lower the chance of liver cancer coming back after surgery.

What could go wrong

This is an early-stage trial testing a technique already used in practice, so the benefit may be small or none. There is also a risk of liver damage from the extra coagulation.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma liver cancer Liver Neoplasms Neoplasms, Second Primary secondary malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hospital del Mar Research Institute

    RECRUITING

    Barcelona, Spain

    Contact

    Contact Email: •••••@•••••

    Contact