LIVER CANCER

This early-stage study tests the safety of combining the immunotherapy drug nivolumab with a procedure called drug-eluting bead transarterial chemoembolization (deb-TACE) in 20 adults with advanced liver cancer. The approach delivers chemotherapy directly to the tumor while also …

This study tests a new treatment called AGAR T cells for children whose solid tumors (like liver cancer or Wilms tumor) have returned or not responded to standard care. The treatment involves taking a patient's own immune cells, adding genes to help them recognize and attack tumo…

This study tests whether the drug nivolumab can help keep liver cancer from returning after surgery or ablation in people at high risk of recurrence. About 545 participants will receive either nivolumab or a placebo, and researchers will track how long they stay cancer-free. The …

This early-phase study tests a treatment called TBI-1301 for people with advanced solid tumors (like sarcoma, melanoma, or ovarian cancer) that have not responded to other therapies. The treatment uses a patient's own immune cells, which are genetically modified in a lab to bette…

This study tests a new device that uses electrical pulses to destroy liver tumors located dangerously close to major blood vessels, where standard heat-based ablation often fails. Twenty adults with liver cancer who cannot have surgery will receive this treatment under general an…

This study tests a treatment called Eye90 microspheres for people with liver cancer that cannot be removed by surgery. The tiny beads deliver radiation directly to tumors to shrink them. The trial involves 120 participants and measures how well the tumors respond and how safe the…

This early-stage trial tests a new treatment for children and young adults with a type of liver cancer that has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells that carry a pr…

This study tests a gradual dose increase of the drug regorafenib in 28 adults with advanced liver cancer who have already tried other treatments. The goal is to see if starting at a lower dose and slowly raising it helps patients handle the drug better and complete more cycles of…

This study tests a precise radiation treatment called SBRT for people with liver cancer or tumors that have spread to the liver. About 280 adults who cannot join other trials will receive SBRT. Researchers will measure how well the treatment controls tumor growth and track any si…

This early-stage study tests a new drug called SH006, given in combination with other treatments, for people with advanced solid tumors (like liver cancer) who have run out of standard options. The main goals are to check safety, find the best dose, and see if the drug shrinks tu…

This study is testing a new blood test called Oncoguard™ Liver to see how well it finds liver cancer early in people who are at high risk, such as those with cirrhosis or hepatitis B. About 2,990 adults will take part, and the test's accuracy will be compared to standard ultrasou…

This study tests a non-invasive treatment called High-Intensity Focused Ultrasound (HIFU) for people with abdominal tumors that cannot be removed by surgery. The goal is to see if HIFU can safely relieve symptoms like pain and improve quality of life. About 38 adults with benign …

This study tests a nurse-led program that starts at least a week before liver cancer surgery. It includes exercise, nutrition support, breathing training, and mental health help. The goal is to see if this program improves patients' strength, nutrition, mood, and reduces complica…

This study collects tumor tissue from about 416 people with various advanced cancers to develop and train a new diagnostic platform called Elephas. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy, compared to standard met…

This study tests whether a special catheter (TriNav) helps doctors better match the test dose with the actual treatment dose during liver cancer radioembolization. About 19 adults with liver tumors that cannot be removed by surgery will take part. The goal is to see if the new ca…

This study looks at whether combining detailed MRI scans, whole genome sequencing, and digital pathology can help doctors choose the best treatment for people with liver cancer. Researchers will study 200 adults who are scheduled for liver surgery. The goal is to see if these adv…

This study looks back at the medical records of 2,500 liver cancer patients treated at a major hospital in Taiwan between 2019 and 2024. Researchers want to see how well newer drugs (like Keytruda, Tecentriq, and Lenvatinib) work compared to older treatments. They will measure su…

This study looks at tissue from liver tumors that were destroyed by ablation. The goal is to see if a special test on that tissue can tell whether the treatment fully killed the cancer or if some cancer cells remain. Standard CT scans can't always tell the difference between new …

This study collects leftover tissue, blood, and other body fluids from 6,000 people with benign or malignant tumors of the soft tissue, gastrointestinal tract, or abdomen. Researchers will use these samples to learn more about what causes these cancers and how to better prevent, …

This study collects blood and tissue samples from 360 people with early-stage liver cancer who have surgery to remove their tumors. Researchers look for patterns in the immune system and antibodies that might help predict if the cancer will come back. The goal is to find better w…

This study collects blood, urine, stool, and tissue samples from 132 adults with liver cancer who have had or will have immunotherapy. The goal is to build a large collection of samples and health data to better understand how liver cancer develops and responds to treatment. Part…

This study compares two types of catheters used during a mapping step before liver cancer treatment. The goal is to see if a pressure-enabled device delivers more radioactivity directly to tumors than a standard catheter. Twenty adults with liver cancer will each receive both cat…

This study collects leftover tissue and blood samples from people with known or suspected cancer who are already scheduled for surgery or biopsy. Researchers will compare cancerous and normal tissues to find differences that could lead to new treatments. About 1,200 adults aged 1…