LIVER CANCER

This study tests a new way to give radiation for liver cancer that uses real-time MRI to guide the beam and adjust the plan during a single treatment session. It aims to improve survival and reduce side effects compared to standard radiation. The trial is for adults with certain …

This study tests a drug called 177Lu-PSMA-617 in people with advanced liver cancer that has spread. The drug delivers radiation directly to cancer cells that have a specific marker (PSMA). The trial will enroll 10 adults whose cancer has worsened after standard treatment, to see …

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study tests a new temperature-sensitive gel that is used during a procedure called TACE to treat liver cancer. The gel is mixed with chemotherapy drugs and injected into the tumor's blood supply to block it and deliver drugs directly. The trial will compare this new gel to a…

This study looks at two ways to use a special dye during liver cancer surgery to help surgeons see and remove tumors more precisely. About 200 adults with liver cancer will take part. The goal is to see which dye method leads to fewer cancer returns and better recovery.

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This early-phase study tests a new drug, SON-DP, in 96 adults with advanced solid tumors, including liver and gastric cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants must have a measurable tumor and be between 1…

This study tests whether adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver. About 100 adults whose cancer cannot be removed by surgery will receive both treatments. R…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study tests a new radiation therapy called vGRID SBRT for people with liver cancer that cannot be removed by surgery. The goal is to find the highest safe dose and see how well it controls tumors. About 18 adults with advanced liver cancer will take part. The approach aims t…

This early-phase trial tests a new experimental treatment called CARE T cells for children and young adults with certain solid tumors (like liver cancer or Wilms tumor) that have returned or not responded to standard therapy. The treatment involves taking a patient's own immune c…

This early-stage trial tests a new mRNA vaccine designed to help the immune system fight advanced liver cancer. It is for people whose cancer has not responded to standard treatments. The main goal is to check safety and see if the vaccine can control the disease.

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed with surgery. The treatment uses short electric pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to see if …

This study is testing whether using a radiofrequency device to lightly burn the edges of the liver after tumor removal can reduce the chance of cancer returning at that spot. About 720 adults with liver cancer (either from colorectal cancer spread or primary liver cancer) will be…

This study tests the drug pembrolizumab (Keytruda) in children and young adults up to age 30 whose liver cancer has come back or not responded to treatment. The goal is to see if the drug can shrink tumors or slow the disease. About 18 participants will receive the immunotherapy,…

This study tests a new imaging tool that uses folic acid and tiny carbon dots to make liver cancer cells glow under a special camera. After surgery to remove liver cancer, the removed tissue is treated with these dots and scanned to see if the glow can help find cancer edges and …

This study is testing a new type of PET/CT imaging that uses special probes to target and highlight digestive system cancers, including cancers of the liver, stomach, colon, pancreas, and more. Researchers want to see how these probes spread in the body and how well they can find…

This study tests whether a new type of ultrasound can find liver cancers that standard ultrasound often misses. About 328 adults at risk for liver cancer will get both standard and new ultrasound scans. The goal is to catch more cancers early, when they are easier to treat.

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study tests whether contrast-enhanced ultrasound (CEUS) can more accurately show if liver cancer has been killed by a targeted radiation treatment called TARE. Standard CT or MRI scans often take months to give clear results, delaying next steps. Researchers will enroll 30 a…

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This study compares standard ultrasound monitoring to ultrasound plus a short, 10-minute MRI (Fast-MRI) for detecting early-stage liver cancer in people with cirrhosis who are at high risk. About 944 participants will be followed for several years to see which method finds more e…

This study tests whether a blood test (GALAD) is better than ultrasound for finding liver cancer early in 5500 people with cirrhosis or chronic hepatitis B. Participants will be randomly assigned to one of two screening methods every six months. The goal is to see which approach …

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study looks at how two types of liver cancer treatments affect patients' quality of life. Researchers will track changes in well-being using surveys before and after treatment. The study includes 78 adults with liver cancer who cannot have surgery, and whose tumors are small…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study tests a new type of CT scan (HyperSight) that may produce clearer images during radiation therapy for cancer. About 50 adults with various cancers will get extra scans to see if the new method improves image quality and could help doctors plan treatment more accurately…

This study is observing 50 adults with advanced cancers (like lung, breast, or colon) who are starting immunotherapy. Researchers want to see if changes in a blood marker called ctDNA can predict early on whether the treatment is working. They will also look at other tumor marker…

This study looks at whether artificial intelligence (AI) can help doctors write more accurate and efficient treatment reports for patients with common cancers like lung, breast, and colon cancer. The researchers will have 40 junior doctors use either an AI tool or traditional met…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. It does not provide any treatment. Up to 1,750 participants will give blood samples, and some may also provide tissue, urine, or stool. The …

This study aims to develop a new 4D-MRI imaging method to track how tumors move when you breathe, which could make radiation therapy more accurate for lung and liver cancer. Researchers will test this technique in 100 healthy volunteers and cancer patients. The goal is to improve…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, it checks their health once a year for 15 years to watch for any long-term side effects. Up to 750 participants with various cance…

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study is creating and testing an educational tool to teach people how to prevent liver cancer. About 40 adults from a community clinic who do not have liver cancer will review the material and give feedback. The goal is to make sure the information is clear, helpful, and eas…

This study looks at whether emotional disorders like anxiety or depression impact how well liver cancer patients respond to immunotherapy. Researchers will follow 651 adults with newly diagnosed liver cancer who are starting treatment. The goal is to see if emotional health affec…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study creates a collection of blood, urine, stool, and other samples from up to 9,150 people with cholestatic liver diseases like primary biliary cholangitis and primary sclerosing cholangitis. The samples and health data will be used by researchers to better understand thes…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study is collecting data from 1500 people with liver tumors who are getting a treatment called thermal ablation, which uses heat to destroy cancer. Researchers will use artificial intelligence to analyze this data to find the best ways to plan and evaluate the treatment. The…

This study aims to understand how the immune system and genes change in people with advanced liver cancer during immunotherapy. Researchers will collect blood and tumor samples from 50 participants before, during, and after treatment. The goal is to find biomarkers that predict h…

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse models, to test new treatments in the future. Participants do not receive any experime…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study aims to make a common liver cancer treatment called TARE more predictable and effective. Researchers will create computer models of each patient's liver blood vessels to simulate how radioactive beads spread during treatment. By analyzing factors like catheter position…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…