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Engineered immune cells take aim at childhood liver cancers

NCT ID NCT04634357

Recruiting now Disease control Sponsor: Eureka Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial investigates a new cell therapy called ET140203 T cells for children and young adults (ages 1–21) with certain liver cancers—hepatoblastoma, hepatocellular carcinoma, or related tumors—that have come back or not responded to standard treatment. Participants must have high levels of a protein called AFP and a specific immune marker (HLA-A2). The study aims to find a safe dose and check whether the therapy can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ET140203 T cells (a type of immune cell therapy)
What this could lead to
If successful, this could offer a new treatment option for children with liver cancers that have not responded to standard therapies.
What could go wrong
This is an early-phase trial with only 12 participants, so results may not apply broadly. The therapy may cause side effects or fail to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatoblastoma hepatocellular carcinoma liver and intrahepatic bile duct neoplasm liver cancer Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMNOS HEPATOBLASTOMA HEPATOCELLULAR CARCINOMA (HCC) LIVER CANCER LIVER NEOPLASMS METASTATIC LIVER CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital Orange County

    RECRUITING

    Orange, California, 92868, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Dana-Farber/Boston Children's Cancer and Blood Disorders Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UCSF Benioff Children's Hospitals

    RECRUITING

    San Francisco, California, 94158, United States

    Contact

    Contact Email: •••••@•••••

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