Can a triple drug attack stop liver cancer from coming back?
NCT ID NCT07790419
First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This trial tests whether combining three treatment approaches can reduce the chance of liver cancer returning after surgery. People who had their liver cancer completely removed but showed signs of microvascular invasion, a risk factor for recurrence, will receive chemotherapy directly into the liver, a daily targeted therapy pill, and an immunotherapy infusion. The study tracks how long participants stay free of cancer and overall survival. The goal is to see if this aggressive combination offers better protection than standard care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A combination of hepatic artery infusion chemotherapy (oxaliplatin and 5-fluorouracil), targeted therapy (donafenib, lenvatinib, or apatinib), and a PD-1 inhibitor (sintilimab, camrelizumab, or tislelizumab)
- What this could lead to
- If it works, this combination could help prevent liver cancer from returning after surgery, potentially improving long-term survival for people with microvascular invasion.
- What could go wrong
- This is a small, single-arm trial with no comparison group, so results may not be definitive. The combination of chemotherapy, targeted drugs, and immunotherapy can cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18-80 years, male or female; 2. Pathologically confirmed hepatocellular carcinoma, with complete resection of all tumor nodules and negative surgical margins; 3. Microvascular invasion (MVI) grade ≥ 1 4. No other history of tumors and no preoperative anticancer treatment. 5. ECOG: 0-1; 6. Baseline blood count tests and blood biochemistry must meet the following criteria: Hemoglobin ≥80 g/L; Absolute neutrophil count ≥1.5×109/L; Platelet count ≥50×109/L; Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤5 times the upper limit of normal (ULN); Total bilirubin ≤3 times ULN; Serum creatinine ≤1.5 times ULN; Albumin ≥28 g/L; prothrombin time (PT) ≤19.5 s; International normalized ratio (INR) ≤2.3 7. Women of childbearing potential must agree to use contraception during the study and for 6 months after the study ends (e.g., intrauterine device, oral contraceptives, or condoms); serum or urine pregnancy test must be negative within 7 days before enrollment, and they must not be breastfeeding; men must agree to use contraception during the study and for 6 months after the study ends; 8. Subjects voluntarily participate in this study, sign the informed consent form, are compliant, and cooperate with follow-up. Exclusion Criteria: * 1\. Patients with any active autoimmune disease or a history of autoimmune disease (including, but not limited to: autoimmune hepatitis, interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism; patients with vitiligo; patients whose childhood asthma has completely resolved and who require no intervention as adults may be included; asthma requiring bronchodilator intervention for medical management cannot be included); 2\. Pregnancy or lactation; 3\. Over 80 years old; 4\. Prior systemic chemotherapy or radiotherapy; 5\. Concomitant malignant pleural effusion or ascites; 6\. History of organ transplantation (including autologous bone marrow transplantation and peripheral stem cell transplantation); 7\. Concomitant infection requiring anti-infective treatment; 8\. Concomitant peripheral nervous system disease or a history of significant psychiatric disease and central nervous system disease; 9\. Diagnosis of other types of malignant tumors within 5 years, excluding non-melanoma skin cancer and carcinoma in situ of the cervix; 10\. Uncorrectable coagulation disorders; 11\. Significant ECG abnormalities or obvious clinical symptoms of heart disease, such as congestive heart failure (CHF), clinically significant coronary heart disease, difficult-to-control arrhythmias, and hypertension; 12\. History of myocardial infarction within 12 months, or cardiac function class III or IV; 13\. Severe liver disease (e.g., cirrhosis), kidney disease, respiratory disease, uncontrolled diabetes, or other systemic diseases; 14\. Individuals deemed unsuitable for inclusion by the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
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- Could a daily mineral make liver cancer therapy work better?