TESTICULAR CANCER

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This early-stage trial tests a new drug called GV20-0251 in people with advanced solid tumors that no longer respond to standard treatments. The main goal is to check the drug's safety. About 10 adults with cancers like liver, lung, or skin cancer will take part. This is not a cu…

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancer that has come back or stopped responding to standard treatments. The drug works by helping the immune system attack cancer cells that have a specific marker called CLD…

This study tests whether adding a drug called tarlatamab to standard radiation therapy is safe and effective for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and bladder cancers. About 30 adults with advanced or returning cancers will receive …

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell cancer (including testicular cancer) who are receiving standard chemotherapy. About 35 participants at high risk for clots will take aspirin alongside their chemo…

This study is testing a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages participants to stay engaged with their follow-up medical care. Abo…

This study compares two standard pain relief methods—morphine given via a spinal injection and methadone given through an IV—for men undergoing testicular cancer surgery. The goal is to see which provides better pain control and reduces the need for additional opioids. About 142 …

This study looks at two common ways to remove a testicle affected by cancer. The goal is to find out if one method causes less pain and requires fewer painkillers after surgery. About 80 adults with testicular cancer will take part, and they will report their pain levels and reco…

This study follows 160 men with good prognosis metastatic testicular cancer to see if surgery (RPLND) causes fewer side effects than chemotherapy. Participants choose or are assigned to either surgery or 3-4 rounds of chemo. Researchers track quality of life, fatigue, and other o…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…