Major study to settle debate: surgery or radiation for aggressive prostate cancer?

NCT ID NCT05931419

Recruiting now Knowledge-focused Sponsor: Comprehensive Cancer Centre The Netherlands Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 837 men with high-risk prostate cancer who choose either robot-assisted surgery or radiation therapy (with or without hormone therapy). Researchers will compare quality of life, side effects, and cancer control over time. The goal is to help patients and doctors make more informed treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors and patients choose the best treatment for high-risk prostate cancer based on quality of life and survival.
What could go wrong: This is an observational study, not a randomized trial, so results may be influenced by patient selection. It will take years to complete and may not provide definitive answers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE ADENOCARCINOMA PROSTATE CANCER

Contacts and locations

Locations

Admiraal de Ruyter Ziekenhuis
RECRUITING

Goes, Netherlands
Albert Schweitzer Ziekenhuis
RECRUITING

Dordrecht, Netherlands
Amsterdam UMC
RECRUITING

Amsterdam, Netherlands
Antoni van Leeuwenhoek Ziekenhuis
RECRUITING

Amsterdam, Netherlands
BovenIJ ziekenhuis
RECRUITING

Amsterdam, Netherlands
Canisius Wilhelmina Ziekenhuis
COMPLETED

Nijmegen, Netherlands
Catharina Ziekenhuis
COMPLETED

Eindhoven, Netherlands
Dijklander Ziekenhuis
RECRUITING

Hoorn, Netherlands
Erasmus Medisch Centrum Rotterdam
RECRUITING

Rotterdam, Netherlands
Franciscus Gasthuis & Vlietland
RECRUITING

Rotterdam, Netherlands
Haaglanden Medisch Centrum
RECRUITING

The Hague, Netherlands
Leids Universitair Medisch Centrum
RECRUITING

Leiden, Netherlands
Maasstad Ziekenhuis
RECRUITING

Rotterdam, Netherlands
Martini ziekenhuis
RECRUITING

Groningen, Netherlands
Maxima Medisch Centrum
COMPLETED

Veldhoven, Netherlands
Noordwest Ziekenhuisgroep
RECRUITING

Alkmaar, Netherlands
OLVG
RECRUITING

Amsterdam, Netherlands
Ommelander Ziekenhuis
RECRUITING

Scheemda, Netherlands
Radboudumc
COMPLETED

Nijmegen, Netherlands
Rode Kruis Ziekenhuis
RECRUITING

Beverwijk, Netherlands
Saxenburgh Medisch Centrum
RECRUITING

Hardenberg, Netherlands
Spaarne Gasthuis
RECRUITING

Hoofddorp, Netherlands
St Jansdal
RECRUITING

Harderwijk, Netherlands
Treant
RECRUITING

Hoogeveen, Netherlands
Universitair Medisch Centrum Groningen
RECRUITING

Groningen, Netherlands
Verbeeten Instituut
RECRUITING

Tilburg, Netherlands
Wilhelmina Ziekenhuis
RECRUITING

Assen, Netherlands
Zaans Medisch Centrum
RECRUITING

Zaandam, Netherlands

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