PROSTATE CANCER

This early-stage trial is testing whether dapagliflozin (Farxiga), a drug used for diabetes and heart failure, is safe and tolerable when taken for four weeks before prostate removal surgery in men with localized prostate cancer. The study will also look for signs that the drug m…

This early-phase trial tested a new approach: taking a patient's own white blood cells, genetically modifying them in the lab to recognize a specific cancer mutation (KRAS G12D), and infusing them back to attack tumors. The study enrolled only 5 adults with advanced gastrointesti…

This study tested a combination of two drugs—tivozanib and enzalutamide—in men with advanced prostate cancer that had stopped responding to standard hormone therapy. Enzalutamide blocks male hormones that fuel cancer growth, while tivozanib cuts off the tumor's blood supply. The …

This study tested a combination of two drugs, bortezomib and docetaxel, in 15 men with advanced prostate cancer that had stopped responding to hormone therapy. The goal was to see if the combo could lower PSA levels and ease pain. The trial was terminated early, so the findings a…

This phase 2 trial tested the drug cabozantinib in men with a hard-to-treat type of prostate cancer that had spread and stopped responding to hormone therapy. The study focused on patients whose tumors had specific genetic changes or had spread to the liver. Only 4 men were enrol…

This study tested a temporary biodegradable balloon placed between the prostate and rectum during radiation therapy for intermediate-risk prostate cancer. The goal was to see if the balloon could reduce radiation damage to the rectum by pushing it away from the prostate. The stud…

This study looked at whether a grape seed extract called OPC or the diabetes drug metformin could lower levels of AGEs (advanced glycation endproducts) in men with prostate cancer who are on hormone therapy. The trial planned to enroll 41 participants but was terminated early. Th…

This study tested a new way to treat prostate cancer using a laser guided by MRI images. Only 2 men took part before the study was stopped. The goal was to see if the treatment was safe and could precisely target cancer while avoiding healthy tissue.

This phase 2 trial tested two drugs—cabozantinib and abiraterone—together in 54 men with castration-resistant prostate cancer that had spread to bones. The goal was to see if the combination could delay cancer growth. However, the study was stopped early by the sponsor for busine…

This phase 2 trial tested the drug pacritinib in 6 men whose prostate cancer had come back after surgery or radiation, shown by rising PSA levels. The goal was to see if the drug could delay further cancer growth. However, the study was terminated early, so we have limited inform…

This early-phase trial tested an experimental immunotherapy called VTP-850 in 22 men whose prostate cancer had returned (shown by rising PSA levels) after initial treatment like surgery or radiation. The therapy used two modified viruses to train the immune system to attack prost…

This early-stage trial tested an experimental drug called NUV-868, alone or with other cancer drugs, in 82 adults with advanced solid tumors (including ovarian, pancreatic, prostate, and breast cancers). The goal was to find safe doses and check for early signs of effectiveness. …

This early-phase study tested a new drug called acapatamab in 212 men with advanced prostate cancer that had stopped responding to standard hormone therapy and chemotherapy. The drug works by helping the body's immune cells attack cancer cells. The main goals were to check safety…

This study looked at whether men with prostate cancer could take a lower dose of the drug abiraterone (combined with prednisone) and still control their cancer. About 50 men who had never taken abiraterone before were enrolled. The goal was to find the smallest dose that still lo…

This study tests a new blood test called EPIDROP that looks for live circulating tumor cells in men with metastatic prostate cancer. The test uses a special technique to isolate single cells and measure their activity. Researchers want to see if EPIDROP is as good as or better th…

This study tested whether a special type of PET/CT scan, called PSMA PET/CT, can better detect if prostate cancer has spread to nearby lymph nodes before surgery. The scan uses a radioactive tracer that sticks to prostate cancer cells, making them visible. The goal was to help do…

This study looked at whether taking fewer systematic biopsy cores (6 instead of 20) during an MRI-targeted prostate biopsy could still detect dangerous prostate cancers while reducing risks like infection and overdiagnosis. The trial involved 126 men with suspicious MRI results. …

This phase 3 trial tested whether an iron-based contrast agent called Ferumoxtran-10 (Ferrotran®) could improve MRI scans to find prostate cancer that has spread to lymph nodes. The study involved 172 men with newly diagnosed prostate cancer at intermediate to high risk of spread…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This study looked at men with low or intermediate-risk prostate cancer to see if 2 MRI-guided radiation treatments cause fewer bowel and bladder side effects than 5 treatments. The goal was to find a shorter treatment plan that is just as safe and less bothersome. The study was s…

This Phase 2 trial tested a neuroscience-based technique combining memory structuring and deep vagal breathing to reduce PTSD symptoms in people with advanced, incurable cancer and their partners. The study enrolled 19 patients who had just received a terminal diagnosis. The appr…

This study tested whether placing a special placental tissue over nerves during prostate cancer surgery helps men regain erections and bladder control faster. Only 3 men participated before the study was stopped early. The approach aimed to protect nerves during surgery, but resu…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different types of PET scans to see which one better highlights cancer cells. The goal was to compare the scans' ability to detect and measure…

This study aimed to see if a simple blood test could predict memory and thinking problems in men with prostate cancer receiving hormone therapy (ADT). Researchers planned to follow 32 men over time, comparing those on ADT to those not on it. The study was stopped early, so result…

This study tested whether an online video simulator helps surgeons learn laparoscopic radical prostatectomy, a surgery for prostate cancer. It enrolled 29 surgeons who were new to the procedure, comparing those who used the simulator to those who did not. The trial was terminated…

This study looked at whether a special monitor (CardioQ-ODM+) could help doctors give the right amount of fluids during robot-assisted prostate surgery. The surgery uses gas and a head-down position, which can affect how well standard fluid monitors work. The study planned to inc…

This early-stage study aimed to see how the experimental drug ceralasertib affects the way the body processes three other drugs (Drug X, Y, and Z) in people with advanced solid tumours. Only one person was enrolled before the study was terminated, so no useful information was gat…

This study tested whether combining two types of scans (PSMA-PET and MRI) can help doctors better target radiation for prostate cancer. The goal was to see if this approach is safe and possible. Only 8 people took part before the study was stopped early.