PROSTATE CANCER

This early-stage trial tested an experimental immunotherapy called VTP-850 in 22 men whose prostate cancer had returned after initial treatment like surgery or radiation. The goal was to check safety and see if the treatment could lower PSA levels, a marker of cancer activity. Th…

This study looked at whether a drug called OPC could lower AGE levels in men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). AGEs are substances that can build up in the body and may cause health problems. The study planned to enroll 41 part…

This study tested the drug cabozantinib in men with a hard-to-treat type of prostate cancer that has spread and no longer responds to hormone therapy. The goal was to see if the drug could shrink tumors or slow the disease, especially in patients with certain gene changes or canc…

This early-stage study tested a new drug called acapatamab in 212 men with metastatic castration-resistant prostate cancer that had stopped responding to standard therapies. The drug works by directing the body's immune cells to attack cancer cells. The main goals were to check s…

This study tested a temporary, biodegradable balloon placed between the prostate and rectum during radiation therapy for intermediate-risk prostate cancer. The goal was to see if the balloon could reduce radiation damage to the rectum by creating more space. The study enrolled 24…

This study tested a new laser system that uses MRI and ultrasound images to precisely target and destroy prostate cancer cells. Only 2 people took part before the study was stopped early. The goal was to see if the treatment is safe and can accurately treat cancer while avoiding …

This study tested a combination of two drugs—enzalutamide (already approved for prostate cancer) and tivozanib (an experimental drug that cuts off a tumor's blood supply)—in men with advanced prostate cancer that had stopped responding to standard hormone therapy. The goal was to…

This study tested a drug called pacritinib in 6 men whose prostate cancer had returned after surgery or radiation. The goal was to see if the drug could slow the rise of PSA levels. The trial was stopped early, so results are limited.

This study tested a new drug called NUV-868, alone or combined with other cancer drugs (olaparib or enzalutamide), in people with advanced solid tumors like ovarian, pancreatic, prostate, or breast cancer. The main goals were to check safety and find the right dose. The study was…

This study tested a combination of two drugs, cabozantinib and abiraterone, in men with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could delay cancer growth or death. However, t…

This study aimed to find the lowest effective dose of the prostate cancer drug abiraterone for men starting treatment. Researchers planned to enroll 50 men and test different doses over 12 weeks, measuring hormone levels and PSA. The study was terminated early, so results are lim…

This study tested whether a special MRI contrast agent called Ferumoxtran-10 (Ferrotran®) can better find prostate cancer that has spread to lymph nodes compared to standard MRI. About 172 men with newly-diagnosed prostate cancer at medium to high risk of spread received an enhan…

This study looked at whether giving only 2 radiation treatments instead of 5 is better for men with low or intermediate-risk prostate cancer. The main goal was to see if fewer treatments cause fewer bowel and urinary side effects. The study was stopped early, but it aimed to help…

This study tested whether placing a special placental tissue over nerves during prostate cancer surgery helps men recover erections and bladder control faster. Only 3 men with early-stage prostate cancer and good pre-surgery sexual function took part. The study was stopped early,…

This study tested a special technique that combines organizing traumatic memories with slow, deep breathing to reduce PTSD symptoms in people with advanced cancer and their partners. The goal was to see if this approach could lower stress, inflammation, and possibly improve survi…

This study looked at whether an online video simulator helps surgeons learn a specific type of prostate cancer surgery. It involved 29 surgeons who were new to the procedure. The main goal was to see if the simulator affected surgery time and complication rates.

This study tested whether combining two advanced imaging techniques (PSMA-PET and MRI) can help doctors better target radiation for men with unfavorable-risk prostate cancer. The goal was to see if this approach is safe and feasible. Only 8 participants were enrolled before the s…

This study looked at whether a special monitor (CardioQ-ODM+) could accurately predict when patients having robot-assisted prostate surgery need extra fluids. The surgery involves gas inflation and a head-down position, which can affect normal fluid measurements. The study enroll…