PROSTATE CANCER

This study is testing an oral drug called pacritinib for men with advanced prostate cancer that has spread and is no longer responding to standard hormone-blocking treatments. About 32 participants will take the drug twice daily to see if it can slow the cancer's growth. The main…

This early-stage trial is testing a new drug called TB511, both by itself and in combination with the immunotherapy drug pembrolizumab (Keytruda). It aims to find a safe dose and see if it can shrink tumors in people with advanced solid cancers, including lung, prostate, colorect…

This study is testing if using a special scan (PSMA-PET) to guide a lower dose of radiation can reduce side effects while still controlling prostate cancer that comes back after surgery. It will involve about 54 men whose prostate cancer has returned, as shown by a rising PSA blo…

This study is testing if adding a drug called trimethoprim to standard hormone therapy helps men with advanced prostate cancer. Researchers want to see if lowering folate levels in the body at the start of treatment makes the cancer more responsive. The main goal is to check the …

This study is testing the safety of a new treatment called Alpha DaRT for men whose prostate cancer has come back locally after initial treatment. Up to 12 participants will have tiny radioactive seeds placed directly into their tumor to deliver a strong, localized dose of radiat…

This study is testing if adding a common diabetes drug, dapagliflozin, to standard hormone therapy helps control advanced prostate cancer that has spread and stopped responding to standard hormone treatments. It will involve 60 men whose cancer has spread and who are starting a s…

This early-stage study is testing whether a shorter, more intense schedule of carbon-ion radiation therapy is safe for men with localized prostate cancer. Instead of the usual 12 treatments, researchers are giving 6 treatments over 3 weeks to see if it controls the cancer while c…

This study is for men with intermediate- or high-risk prostate cancer who are scheduled to receive hormone therapy and radiation. The goal is to see if a special type of imaging scan (PSMA PET/CT), taken during hormone treatment, can help doctors more accurately aim radiation at …

This registry will track the long-term safety and effectiveness of Vanquish water vapor ablation therapy for prostate cancer in real-world settings. It will follow up to 2,500 patients who receive this treatment as part of their regular care. The main goals are to see how well th…

This study aims to find out if testosterone replacement therapy is safe for men who have both low-risk prostate cancer and low testosterone levels. It will follow 35 men who are on active surveillance for their cancer to see if the testosterone treatment causes their cancer to wo…

This study is testing a new radiation treatment called Tb-161 PSMA for men with advanced prostate cancer that has spread and stopped responding to standard treatments. The treatment delivers radiation directly to cancer cells using a targeted approach. Researchers want to see if …

This study is testing whether taking a drug called darolutamide, with or without standard hormone therapy, before surgery can better control high-risk prostate cancer. It will involve 60 men with aggressive, localized prostate cancer. Doctors will see if this pre-surgery treatmen…

This pilot study is testing a new procedure called PFA ablation for men with prostate cancer. It aims to see if the procedure is safe and if it can successfully remove significant cancer from the prostate. The study will enroll 50 men with different stages of prostate cancer to e…

This early-stage study is testing a new drug called SHR-4394 when given alongside other prostate cancer treatments. Researchers want to find the safest and most effective dose and see if the combination helps control the cancer. The trial will enroll about 100 men with advanced p…

This study is testing if adding a newer drug called darolutamide to standard hormone therapy (ADT) can better prevent prostate cancer from returning after surgery. It will involve about 40 men who had surgery for high-risk prostate cancer but did not have extensive lymph node rem…

This study is testing if a short course of hormone-blocking drugs before prostate removal surgery helps control high-risk prostate cancer. Researchers will use a special PET scan to see how the cancer responds to the drugs and if that scan can predict whether the cancer is likely…

This study is testing a shorter, more precise form of radiation therapy for early-stage prostate cancer. It aims to control the cancer while closely monitoring patients' quality of life and side effects. The treatment uses advanced technology that adjusts the radiation plan daily…

This study compares two radiation therapy schedules for men whose prostate cancer returns after surgery. Researchers want to see if a shorter 4-week treatment causes no more side effects than the standard 5-week approach while keeping cancer under control. The study will enroll 4…

This is the first study in people to test a new drug called GLR2037 for men with advanced prostate cancer that has spread. The main goal is to find a safe dose and understand the drug's side effects in 65 participants. Researchers will also take initial measurements to see if the…

This is the first-ever study in humans of a new drug called DXC014, designed for people with advanced solid tumors like lung cancer, melanoma, and prostate cancer. The main goal is to find a safe dose and understand how the body processes the drug. Researchers will also look for …

This study is testing a new high-tech navigation system designed to help surgeons perform more precise prostate cancer removal. It combines multiple advanced scans to create a real-time 3D map during robot-assisted surgery. The goal is to help surgeons better see and remove cance…

This trial is testing a new radioactive drug called Actinium rhPSMA-10.1 for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The drug is designed to find and destroy prostate cancer cells throughout the body using targeted …

This study is testing if a drug called memantine hydrochloride, commonly used for Alzheimer's disease, can help control advanced prostate cancer that has spread and stopped responding to standard hormone therapies. It will involve about 15 men who have already tried one or two ot…

This study is testing if adding a common blood pressure drug, propranolol, to standard hormone-blocking therapy can better shrink tumors in men with high-risk prostate cancer before they have surgery. The goal is to see if this drug combination leads to less or no detectable canc…

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This study is for men with high-risk prostate cancer that hasn't spread to their lymph nodes. It compares two ways of giving radiation therapy: targeting just the prostate versus also treating the entire pelvic area. Doctors will use a special PSMA scan to get a clearer picture o…

This early-stage study is testing the safety of combining two treatments for advanced prostate cancer that has spread to the liver. It will give a radioactive drug that targets prostate cancer cells, along with a separate treatment focused directly on the liver tumors. The goal i…

This early-stage study is testing a new personalized therapy for people with advanced breast or prostate cancer that has spread and stopped responding to standard treatments. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer, and then infu…

This study is testing whether a drug called axelopran can help control advanced cancers of the lung, breast, pancreas, and prostate in patients who are taking opioid pain medication. Researchers want to see if the drug can slow tumor growth, improve bowel function, and reduce inf…

This study is testing if a more targeted form of radiation for prostate cancer can better preserve a patient's urinary quality of life compared to the standard method. It will involve 58 men with intermediate- or high-risk prostate cancer that shows up on a special MRI scan. The …

This study will compare four different approaches to follow-up care after curative prostate cancer treatment to determine which works best. It will track 100,000 men across England who have completed initial treatment, comparing hospital visits, GP care, shared care, and self-mon…

This early-stage clinical trial is testing a new drug called AZD9750 in men with metastatic prostate cancer that has spread. Researchers will study the drug's safety, how it moves through the body, and early signs of effectiveness when given alone or combined with another cancer …

This early study is testing a new radioactive drug called 161Tb-LNC1011 for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The main goals are to find the safest dose and see how the drug travels to and stays in tumors. Resear…

This study compares two hormone therapy approaches for prostate cancer that has spread to nearby lymph nodes but is too small to see on regular scans. Researchers want to know if adding the drug abiraterone to standard hormone therapy, along with radiation, works better than stan…

This study aims to compare four different imaging tracers to see which one best shows prostate cancer tumors on PET/CT scans. Researchers will enroll 9 men with advanced prostate cancer who have already shown positive results on a standard PSMA scan. The study focuses on measurin…

This study aims to find a better way to diagnose serious prostate cancer. It will test if using a detailed MRI scan to guide a targeted biopsy is as effective as the current standard method, which adds many random samples. The goal is to accurately find cancers that need treatmen…

This early-stage study is testing a new radioactive tracer called ⁶⁸Ga-FC516 for use in PET/CT scans. The goal is to see if this new agent is safe, where it goes in the body, and if it can help doctors spot prostate cancer tumors as well as or better than existing imaging methods…

This early study is testing a new fluorescent dye called AS1986NS. It is designed to make prostate cancer cells glow under special light during a biopsy, potentially helping surgeons see the cancer more clearly. The main goal is to check if the dye is safe when given in a very sm…

This study is testing whether watching a suspicious prostate area with two MRI scans over time, instead of acting on just one scan, can help doctors make better decisions. The goal is to reduce unnecessary biopsies and the overtreatment of slow-growing cancers that may not need i…

This study aims to see if a faster, bedside blood test can diagnose clotting problems during surgery more quickly than standard lab tests. It will involve 210 patients undergoing major surgeries where significant bleeding is expected, such as heart or joint replacement operations…

This study is testing a blood test called PROSTest to see if it can help doctors decide which men really need a prostate biopsy. It will enroll 1,500 men who have been referred for a biopsy due to an elevated PSA level or an abnormal physical exam. Researchers will compare the bl…

This study is testing whether a blood test called Stockholm3 can accurately detect when prostate cancer becomes more aggressive in men who are being monitored instead of immediately treated. The goal is to see if this test can help doctors safely follow patients with fewer invasi…

This study aims to see if using follow-up MRI scans can help doctors decide the best time to perform prostate biopsies. It will enroll 1,000 men with suspicious prostate findings to track how their MRI scans change over time. The goal is to avoid unnecessary biopsies while still …

This study is testing a new fluorescent dye designed to make prostate cancer cells glow during robotic surgery. The goal is to help surgeons see and remove more cancer tissue while sparing healthy tissue. The study will enroll 18 men with prostate cancer to check if the dye is sa…

This study is testing whether a new artificial intelligence (AI) tool can help doctors perform better prostate biopsies. It will compare the AI-guided method to the current standard biopsy procedure in 50 men whose MRI scans show unclear or low-risk areas. The main goal is to see…

This study is testing a new, high-resolution ultrasound technique to see if it can better detect aggressive prostate cancer in men who are being monitored instead of treated immediately. It focuses on men whose standard MRI scans show no signs of cancer or have remained stable. P…

This study aims to find out if a newer type of scan (called 18F-PSMA PET/CT) is better than the standard CT scan for checking prostate cancer. It will look at 59 men with prostate cancer to see which scan is more accurate for finding where the cancer is, seeing if treatment is wo…

This study aims to find a better way to detect serious prostate cancer in men whose initial MRI scans are unclear. Researchers will compare two approaches: one using only MRI to guide a biopsy, and another that adds a special PET scan called 18F-PSMA. The goal is to see if the co…

This study is testing a new way to perform prostate biopsies that could improve cancer detection. Researchers want to see if taking samples closer to suspicious areas seen on MRI scans (called 'regional biopsies') works better than the current standard method. The goal is to bett…

This study is testing whether a non-invasive brain stimulation technique, given during surgery, can prevent postoperative delirium—a serious state of sudden confusion—in older adults having urological procedures like prostate or kidney surgery. Researchers will use a magnetic coi…

This study aims to see if giving a local anesthetic block to the abdominal wall before surgery starts is better at reducing the need for strong opioid painkillers during the operation, compared to giving the same block after surgery ends. It will involve 50 adults having robotic …

This study is testing whether starting acupuncture before removing the urinary catheter can help men regain bladder control faster after prostate cancer surgery. Researchers will compare real acupuncture to fake acupuncture in 144 men who recently had surgery. The main goal is to…

This study is testing whether adding electroacupuncture to local anesthesia can make prostate biopsies more comfortable. It will involve 190 men who need this diagnostic procedure. Researchers will compare real electroacupuncture to a sham (fake) version to see if it effectively …

This study is testing whether a form of acupuncture with mild electrical stimulation can help men regain bladder control after prostate removal surgery for cancer. Researchers will compare real electroacupuncture to a fake version in 216 men who recently had surgery. The goal is …

This small pilot study is testing whether a 16-week, live video exercise program is practical and helpful for World Trade Center responders who have prostate cancer. The program aims to improve strength, balance, and overall quality of life for 40 participants who are not very ac…

This study is testing whether a 12-week home-based rehabilitation program delivered via video and online tools is usable and acceptable for men with advanced prostate cancer who live in rural areas. The program includes tailored exercises, education, and counseling sessions, all …

This study is testing whether adding a creatine supplement to a supervised weight training program can help men with prostate cancer who are on hormone therapy. The hormone treatment often causes severe muscle loss and weakness. Researchers want to see if this combination can imp…

This study is testing a web-based support program called SCIPI for men newly diagnosed with prostate cancer that hasn't spread. The program provides easy-to-understand information and tools to help patients prepare for doctor visits and make confident treatment decisions. Researc…

This study compares how two different treatments for prostate cancer affect men's quality of life. Researchers will follow 102 men with favorable intermediate-risk prostate cancer who receive either complete prostate removal surgery or a newer, more targeted ultrasound treatment.…

This study is testing whether a specialized form of talk therapy, called Meaning-Centered Psychotherapy for Latinos (MCP-L), can better reduce anxiety and depression and improve quality of life for Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. It…

This study is testing a web-based tool called CARE that helps cancer patients understand treatment costs, health insurance, and find financial resources. Researchers will enroll 430 patients with gynecologic, prostate, lung, or colorectal cancer to see if using the tool reduces f…

This study is testing whether stem cells can safely help men regain erectile function after surgery for prostate cancer. It will involve 40 men who are having a specific type of prostate removal surgery. Researchers will compare different methods and timings of giving stem cell i…

This study aims to find out if a newer, more precise type of radiotherapy causes fewer side effects than standard radiotherapy for prostate cancer. It will compare digestive and urinary problems in about 188 men receiving one of the two treatments. Patients will track their sympt…

This study is testing a phone app called FOCUS that teaches coping skills to help people with advanced cancer manage common symptoms like fatigue, anxiety, depression, and sleep problems. It aims to make this support more accessible to patients living in rural areas who may have …

This study aims to see if listening to music can help reduce pain and anxiety for men undergoing a prostate biopsy, a procedure used to check for cancer. It will compare pain and stress levels in about 78 men who either listen to music or do not during the biopsy. The goal is to …

This study aims to create better educational resources and tools to help people understand prostate cancer and make informed decisions with their doctors. It will involve patients, caregivers, and healthcare professionals across Europe to design and test these new materials. The …

This study is testing a new computer tool that uses artificial intelligence (AI) to help doctors and medical physicists review radiation treatment plans for prostate cancer. The tool highlights potential errors and differences in how doctors plan treatments, aiming to catch mista…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study is testing a new type of medical scan to see if it can accurately measure where a prostate cancer treatment called Radium-223 goes in the body. Researchers want to see if this scan is practical, safe, and if its measurements relate to other signs of the disease. The go…

This study aims to see if trained Veteran peer navigators can help other Veterans make better-informed decisions about prostate cancer screening. It will involve 228 male Veterans aged 40-69 who are considering screening. The goal is to improve the quality of these decisions by p…

This study aims to understand how migration history and social factors affect prostate cancer care and quality of life for Black immigrant men. Researchers will interview 40 men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. The goal is to…

This study aims to find out which of two low-flow anesthesia methods is safer and more efficient for men having robotic surgery to remove their prostate due to cancer. Researchers will compare a very low flow (0.5 L/min) to a standard low flow (1 L/min) of anesthetic gas, checkin…

This study is testing whether analyzing cancer DNA in urine can help doctors monitor prostate and bladder cancer without invasive procedures. Researchers will collect urine samples from 25 patients at different points during their standard cancer treatments to see if the test wor…

This study aims to understand how well a blood test can detect tiny amounts of leftover cancer DNA after surgery. It will follow 840 patients with breast, lung, prostate, ovarian, or gastric cancer to see if this 'liquid biopsy' can predict if the cancer might come back. The stud…

This study aims to understand why some communities have less access to prostate cancer genetic services and information. Researchers will interview people from underserved groups to learn about their experiences and needs. Using these insights, they will work directly with commun…

This study aims to understand if daily physical activity, measured by step count, is linked to how well older and vulnerable men with advanced prostate cancer respond to standard treatment. Researchers will follow 80 participants for 6 to 12 months to see if step counts relate to…

This study is testing a simple blood test to see if it can predict which men are more likely to experience long-term side effects from a specific type of radiation therapy for prostate cancer. Researchers will give the test to 220 men before they start treatment and then track th…

This study aims to see if a personalized blood test can predict how well treatments work for men with advanced prostate cancer that has spread. Researchers will follow 50 newly diagnosed patients to see if the test, which looks for tiny amounts of leftover cancer, can tell which …

This study aims to understand if exposure to a banned pesticide called chlordecone increases the risk of prostate cancer. Researchers in Martinique will compare 3600 local men—some with prostate cancer, some with negative biopsies, and some with normal PSA levels—measuring pestic…

This study aims to improve treatment for aggressive prostate cancer by testing drugs on mini-tumors grown from a patient's own cancer cells in a lab. Researchers will compare two different lab techniques to see which one better predicts which treatment will work for each individu…