PROSTATE CANCER

This early-phase study tests a new radioactive drug, 161Tb-LNC1011, in 15 men with advanced prostate cancer that no longer responds to hormone therapy. The drug is designed to seek out and deliver radiation directly to cancer cells. The main goals are to check safety, find the be…

This early-stage study tests a new drug called GLR2037 in 65 men with metastatic prostate cancer that has spread to bones or soft tissues. The main goal is to check the drug's safety and how the body processes it. Participants must have had prior hormone therapy and still have ca…

This early-stage study tests whether injecting stem cells from donated fat tissue can help men recover erectile function after prostate removal for cancer. Forty men aged 40-70 with localized prostate cancer will receive either stem cells or a placebo. The goal is to see if the t…

This study tests whether daily online adaptive radiotherapy (ART) can safely deliver fewer, stronger radiation doses for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to either standard radiation or the new adaptive approach…

This early-phase study tests whether immune cells (white blood cells) coated with a special antibody can safely attack HER2-positive metastatic breast and prostate cancers. About 23 adults with advanced cancer will receive weekly infusions for 5 weeks, then every other week. The …

This study tests whether adding darolutamide to standard hormone therapy after prostate removal can delay cancer return in high-risk patients. About 40 men will receive the combination for 2 years. The main goal is to see how many stay cancer-free based on PSA levels.

This early-stage trial tests a new drug called TB511, alone or with pembrolizumab, in 12 adults with advanced solid tumors (lung, prostate, colorectal, or liver cancer) that stopped responding to standard treatments. The goal is to find the safest dose and see if it can shrink tu…

This study tests a new radioactive drug called terbium-161 PSMA in 60 men with advanced prostate cancer that has spread and is no longer responding to hormone therapy or chemotherapy. The drug targets cancer cells and delivers radiation to kill them. Participants will receive thr…

This study tests whether memantine hydrochloride, a drug used for Alzheimer's, can help treat advanced prostate cancer that has stopped responding to standard treatments. About 15 men with metastatic castration-resistant prostate cancer will take the drug alongside their usual th…

This study tests a new navigation system that combines PSMA-PET, MRI, and ultrasound images to guide surgeons during robot-assisted prostate removal. About 98 men with prostate cancer that has spread just outside the gland will take part. The goal is to remove all cancer while pr…

This early-stage study tests a new radioactive drug called 177Lu-FC516 in 13 men with advanced prostate cancer that no longer responds to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also look at whether the drug can…

This long-term registry will follow 2,500 men with prostate cancer who receive Vanquish water vapor ablation therapy, a treatment that uses steam to destroy cancer cells. The study aims to see how well the therapy works in real-world settings and track any complications over time…

This study tests if taking trimethoprim, a common antibiotic, daily for 3 months can safely lower folate levels in men starting hormone therapy for advanced prostate cancer. About 50 men will participate. The goal is to see if this approach is safe and might improve treatment out…

This study is for men with high-risk prostate cancer that hasn't spread to lymph nodes. It uses PSMA-PET scans to precisely target radiation to the prostate and nearby tissues, with or without whole pelvis radiation. The goal is to improve cancer control and reduce side effects. …

This study looks at how daily step counts change in 80 vulnerable adults with metastatic hormone-sensitive prostate cancer who are taking darolutamide plus standard hormone therapy. Researchers want to see if physical activity levels relate to treatment safety and quality of life…

This study tests a new vaccine (TriAdeno) plus a drug (N-803) in 52 men with early-stage prostate cancer who are currently under active surveillance. The goal is to see if this combination can boost the immune system to attack the tumor and prevent it from growing. Participants r…

This study tests a new way to give radiation for prostate cancer using only two treatments instead of the usual five or more. Doctors will use MRI scans to see how the tumor responds after the first dose, then adjust the second dose to target it more precisely. The goal is to saf…

This study compares two types of radiation therapy for prostate cancer: one treats the whole prostate gland, while the other focuses extra radiation on the main tumor. The goal is to see which approach causes fewer bladder and bowel side effects. About 186 adults with prostate ca…

This study tests a new procedure called PFA (pulsed field ablation) to treat prostate cancer that hasn't spread. The goal is to see if it's safe and works well. About 50 men aged 45 or older with low- or favorable intermediate-risk prostate cancer will take part. The main focus i…

This early-phase study tests a new type of radiation (carbon-ion therapy) given in only 6 sessions instead of the usual 12 for men with low- or intermediate-risk prostate cancer. The goal is to see if it is safe and works well. Twenty men will receive the treatment, and some may …

This phase 2 trial tests whether adding dapagliflozin, a common diabetes medication, to standard hormone therapy can better control metastatic castrate-resistant prostate cancer. About 60 adults with advanced prostate cancer that has stopped responding to hormone therapy will be …

This study tests a drug called pacritinib in 32 men with advanced prostate cancer that has spread and stopped responding to standard hormone therapies. The goal is to see if pacritinib can slow or stop cancer growth for at least six months. Participants must have a biopsy showing…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study tests whether a shorter course of radiotherapy (20 sessions over 4 weeks) is as safe and effective as the standard longer course (25 sessions over 5 weeks) for men whose prostate cancer has returned after surgery. About 434 men with a detectable PSA will be randomly as…

This study tests whether adding two extra drugs to standard hormone therapy can more thoroughly shrink high-risk prostate tumors before they are removed. About 94 men with aggressive prostate cancer will receive the combination and then have surgery to check how much cancer remai…

This study tests a new approach called Bioblation, where doctors perform a prostate biopsy and laser treatment in one session for men with severe urinary symptoms and suspected low- to intermediate-risk prostate cancer. The goal is to relieve symptoms quickly and reduce the need …

This study tests a new type of radiation treatment for prostate cancer that has come back after initial therapy. Up to 12 participants will receive tiny implants that release alpha radiation directly into the tumor. The main goal is to check safety, but researchers will also moni…

This study looks at whether testosterone replacement therapy is safe for men who have both low-risk prostate cancer and low testosterone (hypogonadism). Researchers will monitor 35 men over 12 months to see if the treatment causes their cancer to worsen or requires more aggressiv…

This early-stage trial tests a new drug called TRC003 in 90 men with a type of advanced prostate cancer that has stopped responding to standard treatments. The study aims to check the drug's safety and how well it shrinks tumors. Participants will receive up to 6 cycles of TRC003…

This study tests if tamoxifen, a common breast cancer drug, can help men recover normal testosterone levels faster after finishing hormone therapy for prostate cancer. About 96 men who completed hormone therapy will take tamoxifen or a placebo to see if it speeds up recovery and …

This early-stage study tests BPX-601, a CAR-T cell therapy made from a patient's own immune cells, for advanced prostate cancer that has stopped responding to standard treatments. The main goals are to find safe doses and understand side effects. About 36 participants will receiv…

This study tests whether adding the heart medication propranolol to standard hormone therapy before surgery can improve outcomes for men with high-risk prostate cancer. About 30 participants will receive the combination treatment before their prostate removal. The goal is to see …

This study tests a drug called darolutamide, given with or without hormone therapy, before surgery for high-risk prostate cancer. About 60 men will receive the treatment for 3-6 months, then have their prostate removed. The goal is to see if the drug can reduce cancer cells left …

This study is testing a new drug called AZD9750 for men with metastatic prostate cancer that has spread. Researchers want to see if the drug is safe, how the body processes it, and if it shows early signs of fighting the cancer. The trial will test AZD9750 alone and combined with…

This study tests a new biopsy approach for men suspected of having prostate cancer. Instead of taking many random samples (systematic biopsy), doctors will take extra samples only near the suspicious spot seen on MRI. The goal is to catch dangerous cancers while avoiding overdiag…

This study involves 1,908 men aged 50 to 75 with elevated PSA or suspicious exam results. Participants receive an MRI first, and only those with suspicious MRI findings undergo biopsy. The study compares targeted biopsies alone versus combined targeted and systematic biopsies to …

This study compares a new bedside test (viscoelastic test) to standard lab tests for diagnosing bleeding problems during surgery. About 210 adults having high-bleed-risk surgeries (like heart or joint replacement) will participate. The goal is to see which method gives a faster d…

This study tests a new PET scanner designed specifically for the prostate. Researchers want to see if it can find prostate cancer more clearly than standard whole-body scans. About 25 men with known or suspected prostate cancer will get both a standard scan and the new scan, and …

This study looks at whether adding a special PET scan (18F-PSMA) to standard MRI can better find aggressive prostate cancers in men whose MRI results are unclear. About 250 men with suspicious but not definitive MRI findings will be randomly assigned to get either MRI-guided biop…

This study tests whether an artificial intelligence (AI) algorithm can help doctors find prostate cancer more accurately during biopsies. It includes 50 men aged 40 and older who have unclear or low-risk MRI results but high PSA levels. Half will get an AI-guided biopsy, and the …

This study looks at whether a high-resolution ultrasound (micro-ultrasound) can find aggressive prostate cancers that standard MRI might miss. About 90 men with low-risk prostate cancer or those on active surveillance will get a micro-ultrasound exam. If suspicious areas are seen…

This study will follow 1,000 men with suspected prostate cancer to see if repeated MRI scans can help doctors decide when a biopsy is truly needed. By watching how suspicious spots on MRI change over time, the goal is to avoid unnecessary biopsies while still catching dangerous c…

This study tests a special dye that makes prostate cancer cells glow under near-infrared light during robot-assisted surgery. About 18 men with prostate cancer will receive the dye before their prostate removal surgery. The goal is to see if the dye helps surgeons find and remove…

This study will test a new blood test called PROSTest in 1,500 men who are scheduled for a prostate biopsy due to high PSA levels or abnormal exams. The goal is to see if the blood test can accurately tell who has prostate cancer and who doesn't, potentially helping many men avoi…

This study will compare two imaging methods—18F-PSMA PET/CT and standard CT—in men with prostate cancer. The goal is to see if the newer scan is better at finding cancer initially, tracking how well treatment works, and detecting cancer that has come back. About 59 participants w…

This study tests four different radioactive imaging agents to see which one works best for detecting prostate cancer on PET/CT scans. Nine men with advanced prostate cancer will receive each agent and have their scans compared. The goal is to find the probe that gives the cleares…

This early-stage trial tests a fluorescent dye called AS1986NS that may help doctors see prostate cancer cells during a biopsy. Ten men with suspected prostate cancer will receive a tiny dose of the dye before their standard biopsy. The main goal is to check if the dye is safe an…

This study tests a new way to detect prostate cancer early by looking at how suspicious spots on MRI change over time, rather than relying on a single scan. About 380 men with a suspicious MRI lesion will be followed to see if this approach reduces unnecessary biopsies and treatm…

This study tests a new tool called LaserSAFE that uses a special microscope to scan the prostate right after it is removed during surgery. The goal is to see if it can quickly find cancer cells at the edge of the prostate, which helps surgeons decide whether it is safe to spare n…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can prevent postoperative delirium—sudden confusion and disorientation—in older adults after urological surgery. About 220 patients aged 60 and older will re…

This study tests whether targeting only the visible tumor in the prostate (focal brachytherapy) causes fewer urinary problems than treating the whole gland. About 58 men with intermediate- or high-risk prostate cancer will receive either focal or standard whole gland brachytherap…

This study tests whether listening to music during a prostate biopsy can lower pain and anxiety. About 78 men over 50 who need a first-time biopsy will be randomly assigned to either listen to music or not during the procedure. Researchers will compare pain scores, stress levels,…

This study looks at whether giving a local anesthetic to the abdominal wall at the start of robotic prostate surgery, rather than at the end, can reduce the amount of strong painkillers (opioids) needed during the operation. About 50 adults with prostate cancer or benign prostate…

This study looks at how two different treatments for early-stage prostate cancer affect quality of life. One treatment removes the whole prostate (prostatectomy), and the other uses focused ultrasound to destroy only the tumor (focal HIFU). Researchers will follow 102 sexually ac…

This study tests a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) to see if it helps reduce anxiety and depression and improve quality of life in 300 Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. Participants will be randomly a…

This study tests whether a program of daily erectile medication, pelvic floor exercises, aerobic workouts, nutrition advice, and mental wellness techniques can help men recover erectile function and bladder control after robot-assisted prostate removal for prostate cancer. Sixty-…

This study tests whether early electroacupuncture (a type of acupuncture with mild electric pulses) can help men regain bladder control after prostate cancer surgery. About 216 men aged 18 to 80 who had their prostate removed will receive either real or fake electroacupuncture fo…

This study tests whether fezolinetant can reduce hot flashes in men receiving hormone therapy (ADT) for prostate cancer. About 54 men will be randomly assigned to receive the drug or a placebo. The main goal is to see if the drug lowers the severity and frequency of hot flashes, …

This study tests whether starting acupuncture before the urinary catheter is removed can help men control urination better right after prostate cancer surgery. 144 men will receive either real or sham acupuncture sessions, then have their urine leakage measured. The goal is to se…

This study tests a web-based program called SCIPI that gives men newly diagnosed with prostate cancer easy-to-understand information, tools for talking with doctors, and social support. About 200 participants will be randomly assigned to use SCIPI or receive usual care. The goal …

This study tests a program called FOCUS, delivered through a smartphone app and telemedicine, to help people with advanced cancer manage common symptoms like trouble sleeping, worry, sadness, and fatigue. The goal is to improve quality of life and make these skills accessible to …

This study tests a new type of radiation therapy for early-stage prostate cancer that delivers treatment in fewer, stronger doses. The machine adjusts the radiation beam daily to match the patient's anatomy, which may reduce side effects. Researchers will track quality of life an…

This study tests whether a 16-week remote exercise program can improve physical function and quality of life in 40 World Trade Center responders who have had prostate cancer. Participants will join live video exercise sessions three times a week. The goal is to see if the program…

This study tests whether adding electroacupuncture to standard local anesthesia can lower pain and anxiety during a prostate biopsy. About 190 men will receive either real or sham electroacupuncture during the procedure. The goal is to see if this ancient technique makes the mode…

This study looks at how a short, home-based high-intensity workout affects steroid hormones in men with low-grade prostate cancer who are on active surveillance. Researchers will collect saliva samples before and after the exercise to measure hormone changes. The goal is to under…

This study looks at whether a blood test can predict long-term side effects from a precise type of radiation therapy for prostate cancer. Researchers will take a blood sample before treatment and measure how sensitive the cells are to radiation. The goal is to identify patients a…

This study tests a new device that measures radiation dose in real time during a type of cancer treatment called brachytherapy. The goal is to catch any errors in radiation delivery, making treatment safer. About 20 people with prostate or gynecologic cancers will take part. The …

This study is for men with intermediate- or high-risk prostate cancer who will receive hormone therapy and radiation. Researchers want to see if a special scan taken during hormone therapy can help doctors better target the remaining cancer with radiation, while avoiding healthy …

This study looks at 70 men having robot-assisted prostate cancer surgery. It compares two low gas flow settings (1 liter vs 0.5 liter per minute) for the anesthesia drug sevoflurane. The goal is to see which flow keeps breathing and blood gases more stable during the operation. R…

This study looks at whether a blood test that counts and analyzes circulating tumor cells can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, pancreatic, or ovarian cancer. Researchers will collect blood samples from 300 adul…

This study works with 100 people from groups often left out of prostate cancer care—Black African and Caribbean men, transgender and non-binary people with a prostate, and those with limited healthcare access. Researchers will interview them to understand what makes genetic risk …

This study tests whether trained veteran peer navigators can help veterans aged 40-69 make informed choices about PSA screening for prostate cancer. The goal is to improve shared decision-making, reduce confusion, and ensure screening aligns with each veteran's values. The study …

This study focuses on helping people better understand prostate cancer prevention and care. Researchers will work with patients, doctors, and community members to create easy-to-use educational tools. The goal is to improve shared decision-making and reduce health inequalities. A…

This study tests a special microscope that lets surgeons check for leftover cancer cells right during prostate removal surgery. About 20 men with prostate cancer will take part. The goal is to see if this method works well in real time, so surgeons can remove any remaining cancer…

This study looks at whether a blood test can find tiny bits of cancer DNA left after surgery for breast, lung, prostate, ovarian, or stomach cancer. About 840 adults who had their cancer removed will give blood samples over a year. The goal is to learn how often this DNA is found…

This study looks at whether a special PET scan using fluciclovine can help doctors decide on treatment for men whose prostate cancer has returned after initial therapy. It is for men whose standard PSMA PET scan was negative or unclear. The goal is to see if this additional scan …

This study looks at 100,000 men in the UK who had surgery or radiation to cure their prostate cancer. It compares four ways of doing follow-up check-ups: hospital visits, GP visits, shared care, or self-care. The goal is to find which method works best for catching cancer return …

This study aims to understand how a man's migration history affects his quality of life after prostate cancer treatment. Researchers will interview 40 Black immigrant men from Sub-Saharan Africa and the Caribbean who were diagnosed within the last 10 years. The goal is to identif…

This study looks at pain in two common ways to biopsy the prostate: through the rectum or through the skin between the scrotum and anus. Researchers will ask 200 men to rate their expected pain before the procedure and their actual pain after. The goal is to help doctors choose t…

This study aims to see if a special type of scan (low-count quantitative SPECT) can accurately measure where the drug Radium-223 goes in the body. Radium-223 is a radioactive treatment for prostate cancer that has spread to bones, but doctors don't know exactly how much reaches t…

This study looks at how prostate cancer and its treatments affect the quality of life of Black and mixed-ancestry men, a group often left out of research. About 800 participants will fill out questionnaires about their physical and mental health after diagnosis. The goal is to le…

This study will test an artificial intelligence (AI) tool designed to help doctors and physicists review radiation treatment plans for prostate cancer before treatment starts. The AI highlights differences in how doctors plan treatments and flags potential errors, aiming to reduc…

This study tests whether the Stockholm3 blood test can accurately detect when low-risk prostate cancer becomes more aggressive in men who are closely monitored instead of treated immediately. Researchers will compare the test's results to follow-up biopsies in 350 men. If success…

This study explores whether analyzing tumor DNA found in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to see if the test works well. The goal is to develop a u…

This study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will follow 50 newly diagnosed patients to see how their genetic features affect treatment resp…