Smart scans may slash radiation doses for metastatic prostate cancer
NCT ID NCT07674771
First seen Jun 30, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This early-phase trial explores whether PSMA PET scans can help doctors adjust radiation therapy for men with prostate cancer that has spread to 4 to 20 spots in the body. Participants receive standard hormone therapy plus a special PET scan, then targeted radiation to all visible tumors. A repeat scan after three radiation sessions may allow some tumors to skip the final two sessions if they show a complete response. The goal is to see if this adaptive approach can safely reduce the total radiation dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 68Ga-PSMA-11 and adaptive stereotactic ablative radiotherapy (SABR)
- What this could lead to
- If successful, this approach could reduce the amount of radiation needed for each tumor site, potentially lowering side effects while maintaining cancer control.
- What could go wrong
- This is a very early-phase trial with only 30 participants, so results may not apply broadly. The imaging and radiation technique may not shrink tumors as expected.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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