Glow-in-the-dark dye may help surgeons spot hidden prostate cancer cells

NCT ID NCT07725523

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether a fluorescent dye called zopocianine can make prostate cancer cells glow under near-infrared light during surgery. Men with prostate cancer scheduled for prostatectomy receive a single dose of the dye before surgery. The goal is to see if the dye helps surgeons detect and remove cancerous tissue that might otherwise be missed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a fluorescent dye called zopocianine (OTL78) that targets prostate cancer cells and glows under near-infrared light during surgery
What this could lead to
If successful, this approach could help surgeons remove prostate cancer more completely during prostatectomy, potentially reducing the chance of leaving cancerous tissue behind.
What could go wrong
This is an early-phase trial with only 36 participants, so results may not apply broadly. The dye may not reliably distinguish all cancerous tissue, and there is a risk of false positives or false negatives.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Indiana University Health North Hospital

    Carmel, Indiana, 46032, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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