PROSTATE CANCER

This study tested whether adding a radioactive drug called radium-223 to standard targeted radiation (SBRT) helps men with prostate cancer that has returned in a few spots but is still hormone-sensitive. Twelve men participated, receiving either SBRT alone or SBRT plus radium-223…

This early-phase study tested whether injecting a man's own bone marrow stem cells into the penis could safely help restore natural erections after prostate cancer surgery. 18 men with localized prostate cancer and normal erections before surgery took part. The approach aims to r…

This study tested a shorter course of radiation (2-4 weeks) for men whose prostate cancer came back after surgery. The goal was to find the shortest schedule that is safe and effective. Thirty men participated, and researchers monitored side effects and cancer control for two yea…

This study looked at whether eating a whole food plant-based diet for six months could help men with prostate cancer whose PSA levels were rising. Eleven men took part, attending cooking classes and eating mostly plants. The goal was to see if this diet could lower PSA and other …

This study tested a precise type of radiation (SBRT) in 86 men with prostate cancer that had started growing despite hormone therapy. The goal was to see if zapping just the growing spots could slow the cancer down and delay the need for chemotherapy. The researchers also looked …

This study tested whether a new drug (TAK-700) combined with standard hormone therapy helps men with newly diagnosed metastatic prostate cancer live longer compared to the usual combination of bicalutamide and hormone therapy. Over 1,300 men took part. The goal was to see which a…

This study tested a special type of radiation called stereotactic body radiation therapy (SBRT) in 17 men whose prostate cancer returned after earlier radiation. The treatment delivers high doses of radiation in just 5 sessions over 2 weeks, targeting only the tumor. The goal was…

This study tested a shorter radiation treatment called proton-based SABR for men with early-stage prostate cancer. Instead of the usual eight weeks, patients received five treatments over two weeks. The goal was to see if this approach keeps side effects low and maintains quality…

This small pilot study tested a procedure called prostatic arterial embolization in 10 men with low-risk prostate cancer that was only on one side of the prostate. The idea was to cut off blood supply to the tumor, causing it to shrink or stop growing. The study looked at safety …

This early study tested a new laser treatment for prostate cancer that uses MRI and ultrasound images to guide the laser precisely. Ten men with early-stage prostate cancer took part. The main goal was to see if the procedure is safe and feasible, by tracking any side effects or …

This study tested a new drug called ARN-509 in 127 men with advanced prostate cancer that had stopped responding to standard hormone therapy. The goal was to find a safe dose and see if the drug could lower PSA levels, a marker of cancer activity. The study had two phases: first …

This study tested whether giving anti-testosterone medications before, during, and after high-dose, targeted radiation can keep prostate cancer from returning in very high-risk patients. 64 men with aggressive prostate cancer took part. The approach aims to control the disease lo…

This study tested if adding two newer drugs (apalutamide and abiraterone) to standard hormone therapy could better control prostate cancer that has returned after surgery. 504 men with a fast-rising PSA took part. The goal was to see how long the cancer stayed under control, but …

This study tested three treatments in 351 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if combining two immunotherapy drugs (nivolumab and ipilimumab) or using one alone works better than standard chemotherapy (cabazitaxel). Th…

This study tested a cancer vaccine called ETBX-011 in 43 people with advanced cancers (colorectal, lung, breast, or prostate) that make a protein called CEA. The vaccine uses a modified virus to teach the immune system to attack cancer cells. The main goals were to check safety a…

This study tested a new way to give testosterone therapy to men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. Instead of injections, patients took oral testosterone for seven days, then stopped for seven days, repeating this cycle. I…

This study tested a single, high-dose radiation treatment for men with low-risk prostate cancer. The goal was to see how well patients tolerated the procedure and what side effects occurred within the first 6 months. 35 patients received the treatment, and researchers monitored u…

This study tested the drug nivolumab in 8 men whose prostate cancer returned after initial treatment and who had specific genetic changes (MMR-deficient or CDK12-altered). The goal was to see if nivolumab could lower PSA levels without using hormone therapy. While the approach of…

This study looked at how well two drugs (apalutamide and abiraterone) work in Black and White men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. About 93 men took part. The goal was to see if the drugs could delay cancer growth and l…

This study compared two types of radiation therapy for men with intermediate-risk prostate cancer: standard image-guided external beam radiation (IGRT) alone versus IGRT plus a high-dose-rate brachytherapy boost. The goal was to see which approach is more effective and has fewer …

This study tested a drug called 177Lu-PSMA-617, which delivers radiation directly to prostate cancer cells. It involved 94 men in Japan with advanced prostate cancer that had stopped responding to hormone therapy. The goal was to see if the drug could shrink tumors and control th…

This study tested whether adding a bone-targeting drug (Radium-223) to precise radiation therapy (SABR) helps men with prostate cancer that has spread to a few spots (oligometastatic). Sixty-four men participated, and the main goal was to see how long the cancer stayed under cont…

This study looked at men with high-risk prostate cancer to see if adding a drug called TAK-700 to standard hormone therapy and radiation could improve outcomes. About 239 men took part. The main goal was to see if the combination reduced the chance of cancer coming back (measured…

This study tested three different drug combinations in 292 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to see if adding nivolumab (an immunotherapy) to either rucaparib, docetaxel, or enzalutamide could shrink tumors o…

This study tested a combination of two drugs, talazoparib and temozolomide, in 16 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to find the safest dose and see if the drugs could shrink tumors. The treatment is not a cur…

This study tested a new treatment that uses a 3D map to guide microwaves and destroy only the main tumor in men with intermediate-risk prostate cancer. 76 men from Europe took part, and the goal was to see if the cancer was gone 12 months later. The approach aims to control the d…

This study tested whether a small implantable spacer can help protect the rectum from radiation damage during prostate cancer treatment. 175 men who had already received radiation with the spacer were evaluated. The goal was to see if the spacer reduced radiation to nearby organs…

This study tested a drug called enzalutamide in men with a type of prostate cancer that has stopped responding to hormone therapy but hasn't spread yet. The goal was to see if the drug could delay the cancer from spreading to other parts of the body. About 1,400 men took part, an…

This study tested a daily supplement of curcumin (from turmeric) and piperine (from black pepper) in 30 people with early-stage prostate cancer or the blood conditions MGUS and low-risk smoldering multiple myeloma. The goal was to see if the supplement could lower disease markers…

This study tested whether combining two drugs, Radium-223 and enzalutamide, is safe for men with advanced prostate cancer that has spread to bones and no longer responds to hormone therapy. Forty-five participants received the combination to track side effects and how long the ca…

This study tested a new oral drug (BXCL701) combined with an immunotherapy (pembrolizumab) in 98 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to find the right dose and see if the combo can shrink tumors or slow the disease. Participa…

This study tested a new radiation treatment (177Lu-PSMA) in 58 men with prostate cancer that had spread to a few spots but was still hormone-sensitive. The treatment targets cancer cells specifically, aiming to delay disease progression compared to standard care. Results help det…

This study looked at men with a type of prostate cancer that no longer responds to hormone therapy and has spread to only a few spots in the body. Researchers wanted to see if adding focused radiation to standard treatments could delay the cancer from growing or spreading further…

This early-stage study tested a new drug combination for men with advanced prostate cancer that no longer responds to standard hormone therapy. The trial included 42 participants and aimed to see if adding relacorilant to enzalutamide is safe and can help control the disease. Res…

This small pilot study tested a new way to treat low-risk prostate cancer using MRI-guided laser ablation. Seven men with early-stage prostate cancer received the treatment to see if it was safe and could successfully destroy tumors. The goal was to control the disease with fewer…

This study tested a new treatment for men whose prostate cancer returned after initial radiation therapy. It combined a local treatment (brachytherapy) with a radioactive drug (177Lu-PSMA) that targets cancer cells throughout the body. The goal was to control the cancer and poten…

This study tested a device called Pelvic Clock® to help men recover bladder control and sexual function after robotic prostate cancer surgery. 60 men aged 55-80 took part. The device was compared to standard pelvic floor exercises. The goal was to see if more men could achieve ca…

This study looked at 588 men with intermediate-risk prostate cancer to see if adding external beam radiation to brachytherapy (internal radiation seeds) works better than brachytherapy alone. The goal was to see which approach better controls the cancer over time. Results help do…

This early-phase study tested a new treatment schedule for men with castration-resistant prostate cancer. The approach alternates between giving testosterone through the skin and the drug enzalutamide. The main goal was to see if this treatment plan is practical and safe. Thirty …

This study tested whether combining several immunotherapy drugs could help people with advanced prostate cancer that no longer responds to hormone therapy. 59 adults received one of three drug combinations. The goal was to see if the treatments could shrink tumors or lower PSA le…

This study tested a combination of two drugs, abiraterone acetate and prednisone, in 131 men with advanced prostate cancer that had not yet shown up on scans. The goal was to see if the treatment could lower a key cancer marker (PSA) and delay the time until the cancer visibly gr…

This study looked at 74 men with prostate cancer that had come back in up to 5 pelvic lymph nodes after initial treatment. They received high-dose radiation to the affected nodes along with hormone therapy. The goal was to see how long it would take for the cancer to progress aga…

This study tested a treatment called focused ultrasound (HIFU) for men with intermediate-risk prostate cancer. The goal was to destroy only the cancerous part of the prostate, avoiding common side effects like incontinence and impotence from standard treatments. 174 men participa…

This study tested a high-dose internal radiation method called brachytherapy in 43 people with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver the right dose. Participants received…

This study tested a shorter course of radiation therapy (16 sessions instead of the usual 40+) for men with early-stage prostate cancer. The goal was to see if this approach is safe and effective at controlling the cancer while reducing side effects. Researchers tracked urinary, …

This study tested a device called the Vanquish System to see if it can safely destroy cancerous tissue in the prostate. 32 men with prostate cancer who were already scheduled for prostate removal surgery received this treatment first. Researchers then checked the removed prostate…

This study looked at 94 men with advanced prostate cancer that was no longer responding to standard hormone therapy. Researchers tested whether increasing the daily dose of abiraterone from 1000 mg to 2000 mg could stop the cancer from growing. The goal was to see if the higher d…

This study checked the long-term safety of the drug degarelix in 57 men with prostate cancer. Participants received the drug for up to 5 years. The main goal was to see if any serious side effects occurred, such as changes in blood pressure or liver function. The results help doc…

This study tested whether adding short-term hormone therapy (androgen deprivation) to higher-dose radiation therapy helps men with intermediate-risk prostate cancer live longer. Over 1,500 men participated, and researchers tracked overall survival and signs of cancer returning. T…

This study looked at whether a care plan led by a geriatrician and a nurse could help older adults (70+) with cancer live longer and feel better. It included 792 people with different cancers like breast, lung, or prostate. The approach was compared to usual cancer care to see if…

This study compared two ways to detect prostate cancer: using MRI to guide a few targeted biopsies versus the standard method of taking 12 random samples. It involved 108 men aged 45-75 with elevated PSA levels. The goal was to see if the MRI-targeted approach could find cancer j…

This study tested a new imaging agent called [18F]CTT1057 for PET scans to find where prostate cancer has returned in men with rising PSA levels after initial treatment. About 190 men with biochemical recurrence took part. The goal was to see how accurately the scan locates cance…

This study tested a new, rapid PSA test that uses a small drop of blood to quickly screen for prostate cancer. Researchers compared its accuracy to the standard lab test in 94 patients with prostate issues. The goal was to see if the faster test could reliably detect high PSA lev…

This early-phase study tested a new radioactive imaging agent, rhPSMA-7.3 (18F), in 24 people: some healthy volunteers and some with prostate cancer. The goal was to check safety and see how well the agent spreads through the body and lights up cancer cells on scans. The study wa…

This study tested a new, non-invasive method to find and count prostate cancer cells in blood samples from 127 men. The goal was to see if this approach could help diagnose prostate cancer before a traditional biopsy. Researchers used a special filtering technology to capture tum…

This study tested a new deep-learning MRI technique to detect prostate cancer more quickly and accurately. 34 adults who needed a prostate MRI took part. The goal was to see if the new method could find suspicious spots as well as the standard scan, but in less time.

This study tested whether a new, high-resolution ultrasound (micro-ultrasound) can find aggressive prostate cancers as well as MRI does. Over 800 men with suspected prostate cancer were randomly assigned to biopsy guided by micro-ultrasound, MRI, or both. The goal was to see whic…

This study tested a new AI system that combines blood tests (cfDNA) and MRI scans to more accurately detect prostate cancer. The goal was to help men with borderline PSA levels avoid unnecessary biopsies. Over 1,600 men participated, including those with healthy prostates, enlarg…

This study tested whether using MRI to guide prostate biopsies finds more aggressive cancers than the usual ultrasound-guided method. 275 men with suspected prostate cancer had both types of biopsies. The goal was to see if MRI-targeted biopsies detect more high-grade (Gleason 7 …

This study looked at 60 men with suspected prostate cancer to see if a newer type of scan (PSMA PET/CT) works better than MRI for guiding a prostate biopsy. The goal was to find out which method helps doctors spot more aggressive cancers. Results could lead to more accurate diagn…

This study tested a new type of PET/CT scan using a radioactive tracer called copper Cu 64 PSMA I&T to find prostate cancer that has come back after initial treatment. The study involved 235 men with rising PSA levels after surgery or radiation. The goal was to see how accurately…

This study tested a new imaging agent called rhPSMA-7.3 (18F) for PET scans in 391 men with suspected prostate cancer recurrence after initial treatment. The goal was to see how well it could detect cancer that had come back based on rising PSA levels. The results showed the scan…

This study tested a new radioactive imaging agent called 68Ga-OncoACP3 in 20 men with prostate cancer. The goal was to see if it is safe and how much radiation the body receives. The agent helps doctors see cancer spots that other scans might miss.

This study tested whether an artificial intelligence (AI) system can help doctors find prostate cancer on MRI scans. 365 men who needed a prostate biopsy took part. Researchers compared how often AI and senior radiologists detected dangerous cancers. The goal was to see if AI can…

This study tested a new type of PET scan (89Zr-DFO-huJ591) to see if it can find prostate cancer that has spread to other parts of the body, especially bones. 77 men with metastatic prostate cancer received both a standard PET scan and the experimental scan. Researchers compared …

This study tested a dye called IS-002 that makes prostate cancer cells glow under near-infrared light during robotic prostate removal surgery. 59 men with aggressive prostate cancer received the dye before surgery to see if it helps surgeons find and remove all cancer cells. The …

This study tested a new imaging agent called 68Ga-NTA-476 for PET scans in 10 men with prostate cancer. The goal was to see how well it finds tumors compared to the standard scan agent, and to check for side effects. This was the first time this agent was used in humans.

This study involved 55 men whose prostate cancer returned after surgery, with very low PSA levels. Researchers compared two different radioactive tracers (piflufolastat and flotufolastat) used in PET scans to see which one caused less radioactivity in the bladder, potentially mak…

This study tested a new PET imaging agent called [18F]CTT1057 to see how well it can find prostate cancer tumors. 195 men with high-risk prostate cancer who were scheduled for surgery received the PET scan, and the results were compared to tissue samples taken during surgery. The…

This study tested whether a special fluorescent dye called Cytalux can help surgeons better see prostate cancer tissue during surgery. The dye is injected before the operation and glows under near-infrared light, potentially revealing cancer that might otherwise be missed. The go…

This study looked at whether watching a short video before a prostate biopsy helps men feel less pain and anxiety compared to just hearing verbal instructions or looking at static images. Over 200 men participated, and their pain and anxiety levels were measured before and after …

This study tested whether acupuncture, given before a prostate biopsy, can reduce pain and anxiety during the procedure. 72 men were randomly assigned to receive either real acupuncture or a sham (fake) version, in addition to standard numbing medicine. Researchers measured pain …

This pilot study tested a program called ActiveHeal EST (Engage-Sustain-Triumph) to see if it helps breast and prostate cancer survivors keep doing daily activities despite challenges. Thirty adults diagnosed within the last year took part. The study measured resilience, quality …

This study tested whether watching 360° virtual reality movies can help lower fear and anxiety in cancer patients before they start radiation treatment. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched VR movies and then…

This study tested a gel-like spacer placed between the prostate and rectum to protect the rectum during radiation therapy for prostate cancer. Twenty men who were already scheduled for radiation with a hydrogel spacer took part. The main goal was to see if the spacer reduced the …

This study tested whether a prehabilitation program (exercise, education, and support) before robotic prostate removal helps men regain quality of life faster after surgery. 100 men with localized prostate cancer took part. The program aimed to speed up recovery of physical and m…

This study looked at whether a small device that sends mild electrical pulses (TENS) can ease pain during a prostate biopsy. 84 men were randomly assigned to get TENS, a fake TENS device, or standard numbing medicine alone. The goal was to see if TENS lowers pain scores and is sa…

This study tested whether giving a lower dose of the steroid dexamethasone before the chemotherapy drug docetaxel is safe for people with breast or prostate cancer. The goal was to see if a reduced dose could still prevent allergic reactions and fluid buildup while causing fewer …

This study looked at 140 men with prostate cancer who were about to have surgery or radiation. It compared starting a patient empowerment program before treatment versus after. The program included daily texts and emails with tips on exercise, diet, and mental health, plus a supp…

This study tested a remote exercise training program for 27 men with prostate cancer who were receiving hormone therapy (androgen deprivation therapy). The goal was to see if the program was practical and acceptable, and to measure physical activity levels. The study did not test…

This small study tested a 3-month program combining nightly fasting with text-based health coaching for 40 men with prostate cancer on hormone therapy. The program was well-received, with participants showing good engagement and some improvements in weight and quality of life. Ho…

This study looked at whether testosterone replacement therapy (TRT) can safely improve symptoms like low energy and sexual problems in men who had their prostate removed for cancer. 136 men with low-risk prostate cancer and stable PSA levels took part. The goal was to see if TRT …

This study tested a special barbed stitch (Symmcora) for closing the bladder after robot-assisted prostate removal in 70 men with prostate cancer. The goal was to see if it made the stitching step faster without causing more problems like leaks. Results will show if this stitch i…

This study tested if using buffered lidocaine (a less acidic numbing medicine) reduces pain during prostate biopsy. 350 men scheduled for a biopsy rated their pain on a scale. The goal was to see if this simple change makes the procedure more comfortable.

This study tested whether using the UroLift system before radiation therapy is safe for men with both prostate cancer and an enlarged prostate (BPH). Fifteen men participated, and researchers monitored side effects and quality of life for 90 days after treatment. The goal was to …

This small pilot study looked at whether acupuncture can reduce hot flashes and night sweats in men with prostate cancer who are on hormone therapy. Twelve patients in Ireland received acupuncture, and researchers measured how well it worked and how acceptable it was. The goal wa…

This pilot study tested a program called PROWESS for Black and Hispanic men with prostate cancer who are on hormone therapy (ADT). The program used a Fitbit and coaching to help men exercise more, reduce treatment side effects, and improve quality of life. Fourteen men took part,…

This study tested a web-based program called True North Peer Navigation for men with prostate cancer. 184 men who recently finished treatment were matched with trained peer navigators for practical information and emotional support. The goal was to see if the program helps men ta…

This study looked at 112 men aged 70 and older with prostate cancer who were treated with radiation and hormone therapy. The goal was to find out how many of them had sarcopenia (muscle loss) and what factors made it worse. Researchers used a simple questionnaire and body scans t…

This study looked at how closely 200 patients with advanced breast or prostate cancer follow their prescribed oral medication routines. Participants filled out questionnaires about their pill-taking and gave blood samples to check certain health markers. The goal was to understan…

This study followed 25 men who carry BRCA1 or BRCA2 gene mutations, plus a control group, to see if they developed prostate cancer. Researchers called participants to update their health history and track new diagnoses. The goal is to help design better screening programs for men…

This study looked at whether a special gel placed near the rectum can help doctors aim radiation more accurately for prostate cancer. Seventeen men who already had the gel and small metal markers were included. The goal was to see if the gel could replace the markers for daily al…

This study tracked the safety of the drug olaparib in over 1,000 Chinese patients with ovarian or prostate cancer. Researchers recorded side effects and how doctors managed them in everyday practice. The goal was to better understand the drug's real-world safety profile in this p…

This study tested whether combining PET/MRI scans with machine learning can more accurately identify how aggressive solid tumors are. Researchers scanned 49 adults with prostate cancer, liver cancer, kidney cancer, or brain tumors. The goal was to improve diagnosis, not to treat …

This study looked at whether teaching men with advanced prostate cancer about orchiectomy (surgery to remove the testicles) would make them more likely to choose it over lifelong hormone therapy. 101 men who were already on hormone therapy for at least a year took part. The goal …

This study tested a new education program for men with metastatic prostate cancer who are taking next-generation hormone therapy. The program was designed to help patients learn more about their disease, stick to their medication, and improve their quality of life. The study invo…

This study tested whether a special 2D grid can make CT scans clearer for people with prostate, head/neck, or upper abdomen cancers. Researchers compared standard scans to those taken with the new grid in 43 patients. The goal was to see if the grid reduces image errors and impro…

This early-phase study tested whether giving rituximab (a drug that depletes B cells) before prostate removal surgery could reduce B cell levels in the tumor. Eight men with high-risk prostate cancer received four weekly doses before their scheduled prostatectomy. The main goal w…

This small feasibility study looked at whether advanced MRI scans can be used to adjust radiation treatment for high-risk prostate cancer. Five men with aggressive prostate cancer received standard hormone therapy and radiation, while researchers tested if MRI could reliably trac…

This study tested a digital tool (a chatbot) to help cancer survivors learn about genetic testing for hereditary cancer risk. 50 adults who had certain cancers (like breast, ovarian, or prostate) took part. The goal was to see if the chatbot was easy to use and if it helped more …

This study tested whether a special PET scan can measure low oxygen levels (hypoxia) in prostate cancer tumors. 18 adults with intermediate to high-risk prostate cancer received a tracer called FAZA before their standard treatment. The goal was to see if this imaging method is fe…

This study looked at whether detailed analysis of PET scans (called radiomics) can help predict how aggressive a person's prostate cancer is. Researchers studied 70 men with newly diagnosed, intermediate- or high-risk prostate cancer who were scheduled for surgery. They compared …

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to use a mobile website, receive two motivational coaching calls, o…

This study looked at whether androgen deprivation therapy (ADT), a hormone treatment for prostate cancer, can reduce the heart's pumping ability. Researchers compared heart function in prostate cancer patients who had ADT, those who did not, and cancer-free individuals. The goal …

This study tested an online decision aid called 'Talk to Nathan' to see if it helps men aged 55-69 make informed choices about prostate cancer screening. 88 men used either this tool, a standard decision aid, or standard education materials. Researchers measured changes in knowle…

This study tested a new automated method to grow cancer cells from patients with metastatic cancers (like prostate, breast, lung) inside chicken eggs. The goal was to see if this system could successfully grow tumors from patient samples, which could help doctors study cancer and…

This study looked at how the antibiotic rifampicin changes the way the body processes HRS-5041, a potential prostate cancer drug. Sixteen healthy men took HRS-5041 tablets with and without rifampicin to measure drug levels and safety. The goal was to gather information for future…

This pilot study tested a web-based tool called MAP to help men with low-risk prostate cancer stay on active surveillance. Active surveillance means closely monitoring the cancer instead of treating it right away. The study enrolled 39 men aged 55 and older and measured how well …

This study tested whether iPhones and Apple Watches can help monitor symptoms and activity levels in people with cancer. 49 adults receiving cancer treatment at the NIH wore an Apple Watch and used an iPhone for 4 months. The goal was to see if these devices could reliably measur…

This study tested a new blood test that looks for cancer cells floating in the bloodstream (circulating tumor cells) in 40 men with advanced prostate cancer. The goal was to see if changes in these cells could predict whether the drug abiraterone acetate would work. If successful…

This study reviewed medical records from over 1,300 men with metastatic castration-sensitive prostate cancer to see how long they actually take the drugs apalutamide or enzalutamide. It is not a clinical trial but an observation of real-world treatment patterns. The goal is to un…

This study looked at why men with prostate cancer who receive hormone therapy (ADT) often develop high blood pressure. Researchers measured how the nervous system and kidneys control blood pressure in 10 men before and after starting ADT. The goal was to understand the causes so …

This completed study looked at how men from different racial and ethnic backgrounds think about their genetic risk for prostate cancer. Researchers asked 100 men aged 40 and older who had never had prostate cancer to share their beliefs and provide a saliva sample. The goal was t…

This study tested a program called KanSurvive-ECHO to help rural primary care clinics provide better follow-up care for cancer survivors. Researchers worked with 15 clinics to improve tasks like scheduling cancer screenings, checking for distress, and tracking weight and tobacco …

This study followed 831 men aged 60 and older with prostate cancer who were starting hormone therapy (GnRH agonists). Researchers tracked changes in quality of life over six months, comparing different age groups. The goal was to understand how this common treatment affects older…

This study asked 51 adults with localized prostate cancer, along with their healthcare providers, about their views on using artificial intelligence (AI) as a tool to help diagnose the disease. Researchers also explored whether people would be willing to share their health data t…

This study tested whether a multimedia educational program helps African American men and their doctors make shared decisions about PSA-based prostate cancer screening. About 161 African American men aged 40-69 took part. Half received the educational program, and the other half …

This study tested a program for older adults (ages 65-90) who had breast, colorectal, or prostate cancer. A community health worker assessed their health and provided coaching to address issues often missed after cancer treatment. The goal was to see if this approach is feasible …

This study did not test a new treatment. Instead, researchers looked at the medical records of over 6,000 prostate cancer patients who received a drug called 177Lu-PSMA-617. They wanted to understand who got the drug, what treatments they had before, and how long they lived. The …

This study tested whether combining MRI and ultrasound imaging with single-cell analysis of biopsy samples can better predict how prostate cancer will progress. Researchers enrolled 600 men scheduled for a special targeted biopsy. The goal was to see if they could grow prostate c…

This pilot study looked at whether a patient navigator could help Black breast and prostate cancer patients complete a shorter course of radiation therapy. The study enrolled 30 African-American adults with these cancers. Researchers used surveys to understand barriers to care an…

This study looked at how often a specific gene change (called HOXB13 c.853delT) occurs in men of African descent with prostate cancer in Martinique. Researchers tested 465 men to find the frequency of this mutation. The goal was to better understand the genetic factors behind the…

This study looked at 30 men with prostate cancer to understand why MRI and PSMA-PET scans sometimes find different cancer spots. Researchers used stored tissue samples to study the genes and molecules of these mismatched spots. The goal was to learn if these spots are harmless, a…

This study collected urine and blood samples from 80 men, including those with prostate cancer, those with suspected cancer, and healthy volunteers. The goal was to find genetic markers (long non-coding RNA) that could help diagnose prostate cancer and predict its progression wit…

This study looked at gene activity in prostate tissue from 867 men to better understand how prostate cancer develops and grows. Researchers compared genetic information with patient health records to find links between genes and disease outcomes. The goal was to learn more about …

This study collected blood and urine samples from 61 men with prostate cancer and healthy volunteers. Researchers looked for cancer DNA in these samples to find better ways to detect and track prostate cancer without invasive procedures. The goal is to improve future diagnosis an…

This study examined over 1,200 men with advanced prostate cancer who received a radioactive drug called Lutetium-177. Researchers wanted to see what types of patients get this treatment, how many doses they receive, and how their PSA levels change. The goal was to understand how …

This study looked at 185 men with low-risk prostate cancer who chose active surveillance (monitoring instead of immediate treatment). Researchers used a genetic risk score based on common DNA variants to see if it could predict when the cancer might progress. The goal is to help …

This study collected MRI and 3D ultrasound images from 2 men who had their prostate removed due to cancer. The goal was to create a database that researchers can use to develop a computer system that spots tumors without needing a biopsy. The study did not test any treatment or d…

This study looked at 382 men with low-grade prostate cancer to find clues that might predict if the cancer is actually more aggressive than it appears. Researchers collected medical information and biological samples to build a risk prediction tool. The goal is to help doctors de…

This study looked at whether a simple blood test can predict which patients will have long-term side effects from radiation therapy. Researchers measured how well certain immune cells die after radiation in 885 people with breast or prostate cancer. The goal was to see if this te…

This study tested new guidelines for PSA screening in 49 men aged 40-75 with elevated PSA levels. The goal was to improve how doctors decide when to start and stop screening, how often to repeat it, and when to refer for biopsy. Researchers compared PSA test rates, biopsy complic…

This study looked at medical records of 507 veterans with prostate cancer who started taking relugolix between 2020 and 2023. Researchers wanted to understand who these patients were, what other treatments they had received, and where they lived. The goal was to describe real-wor…

This early-phase study looked at whether giving a single, short course of the drug flutamide can create DNA breaks in prostate cancer cells. The 25 participants were already receiving standard hormone therapy and brachytherapy. The goal was to see if this approach could make canc…

This study surveyed 109 men with prostate cancer and women with breast cancer to see how often they used complementary and alternative medicines (like supplements) during radiation therapy. Participants filled out surveys at three different times to track any changes in their use…

This study looked at 33 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers analyzed tiny molecules called microRNAs in blood and tissue samples to see if they could predict which patients would not benefit from chemotherapy or newer hormone …

This study looked at whether a new type of camera (CZT) can accurately measure the radiation from a prostate cancer drug called lutetium. Researchers used past images from 20 patients to compare different energy levels. The goal was to see if the camera gives reliable measurement…

This study looked at whether using a special combination of PET-CT, choline, and MRI scans together can help doctors better plan radiation therapy for men with high-risk prostate cancer. Twenty patients were enrolled to compare the new imaging method with standard scans. The goal…

This study analyzed data from over 257,000 Swedish men aged 75-79 to see if PSA screening reduces deaths from prostate cancer. Since no clinical trials have focused on this age group, researchers used existing health records to compare men who were screened with those who were no…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to track these DNA levels. The goal was to gather basic information that could help …

This study compared two methods of prostate biopsy in 840 men who needed the procedure due to suspected prostate cancer. One method goes through the rectal wall, the other through the skin between the scrotum and anus. The goal was to see which approach causes fewer infections an…

This study tested a new way to take prostate biopsies using MRI guidance through the perineum (the area between the scrotum and anus) instead of the usual method through the rectum. The goal was to see if this approach causes fewer complications and hospital readmissions, and if …

This study created a biobank to collect health information, saliva, and tumor samples from African American men with prostate cancer in Florida. Researchers want to learn if smoking makes prostate cancer more aggressive. About 592 men took part by filling out questionnaires and p…

This early-stage study looked at whether an angelica herbal supplement is safe for men with prostate cancer and how the body processes it. Twelve men took increasing doses over several weeks while researchers monitored heart safety and blood tests. The goal was only to gather saf…

This study looked at how colorectal and prostate cancer affect the energy centers (mitochondria) in muscle cells, and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery for these cancers did either resistance training or high-intensity interva…

This study looked at two ways to manage prostate cancer that comes back after surgery. Some men got radiation right away, while others were monitored with regular PSA tests and a special scan only when PSA rose further. The goal was to see if monitoring with delayed imaging is a …

This study looked at 168 men with metastatic hormone-sensitive prostate cancer to see if a model using PSMA-PET scans and routine medical information could predict how well they would respond to standard first-line treatment. The goal was to help doctors better understand which p…

This study tested whether a brief educational session in the clinic could encourage more men with prostate cancer to get germline (inherited) genetic testing. About 50 men who were eligible for testing but had not done it yet took part. The goal was to see if learning more about …