Prostate cancer drug showdown: which is safer for the heart?

NCT ID NCT05605964

Completed Disease control Sponsor: Sumitomo Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 3 study compared the risk of major heart problems between two hormone therapies—relugolix (a pill) and leuprolide (an injection)—in 387 men with prostate cancer. The trial was stopped early by the sponsor, but enrolled patients could continue treatment for up to a year. The main goal was to see which drug caused fewer serious heart events.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Relugolix (tablet) and leuprolide (injection)

What this could lead to

If relugolix proves safer for the heart, it could become a preferred hormone therapy for men with prostate cancer who have cardiovascular concerns.

What could go wrong

The trial was stopped early by the sponsor, so results are incomplete. It is unclear whether relugolix truly lowers heart risks compared to leuprolide.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

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Locations

Adult and Pediatric Urology P.C.

Omaha, Nebraska, 68114, United States
Adult and Pediatric Urology P.C. Satellite

Council Bluffs, Iowa, 51501, United States
Advanced Urology Associates

New Lenox, Illinois, 60451, United States
Advanced Urology Institute

Daytona Beach, Florida, 32114, United States
Albany Medical College

Albany, New York, 12208, United States
Altru Cancer Center

Grand Forks, North Dakota, 58201, United States
Altru Health System Satellite

Grand Forks, North Dakota, 58201, United States
Altru Professional Center Satellite

Grand Forks, North Dakota, 58201, United States
Arizona Urology Specialists, PLLC

Tucson, Arizona, 85704, United States
Arkansas Urology

Little Rock, Arkansas, 72211, United States
Associated Medical Professionals of NY, PLLC

Syracuse, New York, 13210, United States
Associated Urological Specialists

Chicago Ridge, Illinois, 60415, United States
Associated Urologists of North Carolina

Raleigh, North Carolina, 27612, United States
Augusta University

Augusta, Georgia, 30912, United States
Capital Health Medical Center - Hopewell

Pennington, New Jersey, 08534, United States
Carolina Urologic Research Center

Myrtle Beach, South Carolina, 29572, United States
Central Ohio Urology Group

Gahanna, Ohio, 43230, United States
Central Ohio Urology Group Satellite

Gahanna, Ohio, 43230, United States
Comprehensive Urologic Care

Lake Barrington, Illinois, 60010, United States
Comprehensive Urology

Royal Oak, Michigan, 48073, United States
East Coast Institute for Research, LLC

Jacksonville, Florida, 32216, United States
East Coast Institute for Research, LLC Satellite

Jacksonville, Florida, 32204, United States
East Coast Institute for Research, LLC Satellite

Jacksonville, Florida, 32256, United States
Florida Urology Partners, LLP

Tampa, Florida, 33609, United States
Florida Urology Partners, LLP Satellite

Tampa, Florida, 33578, United States
Florida Urology Partners, LLP Satellite

Tampa, Florida, 33615, United States
Genesis Research , LLC

Los Alamitos, California, 90270, United States
Genesis Research, LLC

San Diego, California, 92123, United States
Genesis Research, LLC Satellite

Downey, California, 90241, United States
Genesis Research, LLC Satellite

Sherman Oaks, California, 91411, United States
Genesis Research, LLC Satellite

Torrance, California, 90503, United States
Genesis Research, LLC Satellite

Torrance, California, 90505, United States
Georgia Cancer Center Satellite

Augusta, Georgia, 30912, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
Guthrie Medical Group, PC

Sayre, Pennsylvania, 18840, United States
Helios CR, LLC

Middleburg Heights, Ohio, 44130, United States
Houston Metro Urology CRC, LLC

Houston, Texas, 77027, United States
IU Health Arnett Cancer Center

Lafayette, Indiana, 47904, United States
IU Health Ball Memorial Hospital Satellite

Muncie, Indiana, 47303, United States
Illinois CancerCare - Bloomington Satellite

Bloomington, Illinois, 61704, United States
Illinois CancerCare - Galesburg Satellite

Galesburg, Illinois, 61401, United States
Illinois CancerCare - Ottawa Satellite

Ottawa, Illinois, 61350, United States
Illinois CancerCare - Pekin Satellite

Pekin, Illinois, 61554, United States
Illinois CancerCare - Peru Satellite

Peru, Illinois, 61354, United States
Illinois CancerCare - Washington Satellite

Washington, Illinois, 61571, United States
Illinois CancerCare, P.C.

Peoria, Illinois, 61615, United States
Intermountain Medical Center Satellite

Murray, Utah, 84107, United States
Keystone Urology Specialists

Lancaster, Pennsylvania, 17604, United States
Lake City Cancer Center, LLC

Lake City, Florida, 32024, United States
Lake Regional Health System

Osage Beach, Missouri, 65065, United States
Logan Regional Hospital Satellite

Logan, Utah, 84341, United States
Lowcountry Urology Clinics

North Charleston, South Carolina, 29406, United States
McKay-Dee Hospital Satellite

Ogden, Utah, 84403, United States
Medstar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Michigan Institute of Urology

Troy, Michigan, 48084, United States
MidLantic Urology

Bala-Cynwyd, Pennsylvania, 19004, United States
NorthShore University Health System - Evanston Hospital

Evanston, Illinois, 60201, United States
NorthShore University Health System - Glenbrook Hospital Ambulatory Care Center Satellite

Glenview, Illinois, 60026, United States
NorthShore University Health System - Highland Park Hospital Ambulatory Care Center Satellite

Highland Park, Illinois, 60035, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oncology Specialists of Charlotte

Charlotte, North Carolina, 28207, United States
Orange Coast Memorial Medical Center

Fountain Valley, California, 92708, United States
Pacific Cancer Care

Monterey, California, 93940, United States
Potomac Urology Center, PC

Alexandria, Virginia, 22311, United States
Potomac Urology Satellite

Woodbridge, Virginia, 22191, United States
Robert Packer Hospital Satellite

Sayre, Pennsylvania, 18840, United States
SG Research LLC

Miami, Florida, 33145, United States
San Bernadino Urological Associates Medical Group

San Bernardino, California, 92404, United States
Specialty Clinical Research of St. Louis

St Louis, Missouri, 63141, United States
Spokane Urology

Spokane, Washington, 99202, United States
St. George Regional Hospital Satellite

St. George, Utah, 84790, United States
St. Luke's Cancer Institute - Fruitland Satellite

Fruitland, Idaho, 83619, United States
St. Luke's Cancer Institute - Meridian Satellite

Meridian, Idaho, 83642, United States
St. Luke's Cancer Institute - Nampa Satellite

Nampa, Idaho, 83687, United States
St. Luke's Cancer Institute Satellite

Twin Falls, Idaho, 83301, United States
St. Luke's Magic Valley Medical Center Satellite

Twin Falls, Idaho, 83301, United States
St. Luke's Meridian Medical Center Satellite

Meridian, Idaho, 83642, United States
St. Luke's Nampa Medical Center Satellite

Nampa, Idaho, 83687, United States
St. Luke's Regional Medical Center

Boise, Idaho, 83712, United States
St. Luke's Regional Medical Center Satellite

Boise, Idaho, 83712, United States
St. Vincent - Frontier Cancer Center

Billings, Montana, 59102, United States
St. Vincent Healthcare Satellite

Billings, Montana, 59101, United States
Swedish Hospital Satellite

Chicago, Illinois, 60625, United States
The Urology Place

San Antonio, Texas, 78240, United States
Tower Urology

Los Angeles, California, 90048, United States
Tri Valley Urology Medical Group

Murrieta, California, 92562, United States
Tri Valley Urology Medical Group Satellite

Murrieta, California, 92563, United States
Tri Valley Urology Medical Group Satellite

Temecula, California, 92592, United States
TriState Urologic Services PSC Inc.

Cincinnati, Ohio, 45212, United States
UH Minoff Health Center at Chagrin Highlands

Orange, Ohio, 44122, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University Hospitals Seidman Cancer Center at UH Avon Health Center Satellite

Avon, Ohio, 44011, United States
University Hospitals Seidman Cancer Center at UH Mentor Health Center Satellite

Mentor, Ohio, 44060, United States
University of New Mexico Comprehensive Cancer Center

Albuquerque, New Mexico, 87131, United States
Urologic Surgeons of Washington

Washington D.C., District of Columbia, 20036, United States
Urology Associates of Mobile

Mobile, Alabama, 36608, United States
Urology Associates, P.C.

Nashville, Tennessee, 37209, United States
Urology San Antonio Clinical Trials

San Antonio, Texas, 78229, United States
Urology of Indiana, LLC

Greenwood, Indiana, 46143, United States
Urology of Indiana, LLC Satellite

Carmel, Indiana, 46032, United States
Urology of St. Louis Satellite

St Louis, Missouri, 63141, United States
Urology of Virginia

Virginia Beach, Virginia, 23462, United States
Utah Valley Hospital

Provo, Utah, 84604, United States
Valley Cancer Associates

Harlingen, Texas, 78550, United States
Virginia Urology

Richmond, Virginia, 23235, United States
Wichita Urology Group

Wichita, Kansas, 67226, United States
Wichita Urology Group Satellite

Wichita, Kansas, 67205, United States
Wichita Urology Group Satellite

Wichita, Kansas, 67206, United States