New drug cocktail shows promise in slowing advanced prostate cancer

NCT ID NCT01314118

Completed Disease control Sponsor: Janssen Biotech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of abiraterone acetate and prednisone in 131 men with advanced prostate cancer that had not yet spread on scans. The goal was to see if the drugs could lower PSA levels and delay cancer progression. Participants took daily pills alongside standard hormone therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

abiraterone acetate plus prednisone

What this could lead to

If successful, this combination could help men with advanced prostate cancer keep their disease under control longer before it spreads.

What could go wrong

This is a small, early-phase study without a comparison group, so results may not be definitive. Side effects from the drugs can include liver problems, high blood pressure, and fluid retention.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER PROSTATIC NEOPLASM

Contacts and locations

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Locations

Study site

Homewood, Alabama, United States
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Huntsville, Alabama, United States
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Tucson, Arizona, United States
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Los Angeles, California, United States
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San Diego, California, United States
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San Francisco, California, United States
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Aurora, Colorado, United States
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Denver, Colorado, United States
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Aventura, Florida, United States
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Orange City, Florida, United States
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Atlanta, Georgia, United States
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Evanston, Illinois, United States
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Galesburg, Illinois, United States
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Glenview, Illinois, United States
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Melrose Park, Illinois, United States
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Fort Wayne, Indiana, United States
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Jeffersonville, Indiana, United States
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New Orleans, Louisiana, United States
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Baltimore, Maryland, United States
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Rockville, Maryland, United States
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Boston, Massachusetts, United States
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Lansing, Michigan, United States
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Omaha, Nebraska, United States
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Lawrenceville, New Jersey, United States
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Albany, New York, United States
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Brooklyn, New York, United States
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Buffalo, New York, United States
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Garden City, New York, United States
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New York, New York, United States
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Poughkeepsie, New York, United States
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Staten Island, New York, United States
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Chapel Hill, North Carolina, United States
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Raleigh, North Carolina, United States
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Cincinnati, Ohio, United States
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Cleveland, Ohio, United States
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Lancaster, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Greenville, South Carolina, United States
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Myrtle Beach, South Carolina, United States
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Nashville, Tennessee, United States
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Arlington, Texas, United States
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Houston, Texas, United States
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Seattle, Washington, United States
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Milwaukee, Wisconsin, United States