Vaccine-Chemo combo shows promise against spread prostate cancer
NCT ID NCT02649855
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding a prostate cancer vaccine (PROSTVAC) and chemotherapy (docetaxel) to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has spread. 74 men with metastatic castration-sensitive prostate cancer took part. The goal was to see if the combination could boost the immune system's ability to fight the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PROSTVAC (a vaccine made from viruses that trains the immune system to attack prostate cancer cells) and docetaxel (a chemotherapy drug)
What this could lead to
If it works, this could point toward a more effective combination treatment for metastatic prostate cancer that harnesses the immune system.
What could go wrong
This is a small, early-phase (Phase 2) study with only 74 participants, so results may not apply to all patients. The vaccine and chemo combination may cause side effects like fatigue, infection, or allergic reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States