New combo therapy aims to delay prostate cancer relapse in patients with limited spread
NCT ID NCT02274779
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a combination of high-dose radiation and hormone therapy (leuprorelin) in 74 men with prostate cancer that had returned in up to 5 pelvic lymph nodes after initial treatment. The goal was to see if this approach could delay further cancer growth or relapse. Participants received radiation to the affected nodes plus six months of hormone therapy, and researchers tracked how long it took for the cancer to progress again.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Leuprorelin (Eligard) hormone therapy plus high-dose radiation therapy
- What this could lead to
- If successful, this combination could delay the return of prostate cancer after initial treatment, potentially extending the time before more aggressive therapy is needed.
- What could go wrong
- This is a small, early-phase trial (74 participants) with no control group, so results may not apply broadly. Hormone therapy has side effects like hot flashes and fatigue, and the treatment may not prevent eventual relapse.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
ICO Paul Papin
Angers, France
-
ICO René Gauducheau
Saint-Herblain, 44800, France
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