MRI-Targeted biopsies may outshine standard needle probes for aggressive prostate cancer

NCT ID NCT02485379

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two ways to biopsy the prostate in 275 men with suspected cancer. The standard method takes random samples from the gland, which can miss aggressive tumors or find harmless ones. The new method uses MRI images to guide the needle to suspicious spots. The goal was to see if MRI-targeted biopsies catch more aggressive cancers (Gleason score 7 or higher) than the standard approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could make MRI-targeted biopsy the new standard for detecting aggressive prostate cancer, reducing missed diagnoses and unnecessary treatments.
What could go wrong
This is a completed diagnostic study, not a treatment trial. Results may not change practice if they show only modest improvement or if MRI is not widely available.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Nancy Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHU de Saint-Etienne

    Saint-Etienne, 42055, France

  • CLIMAL (Centre Libéral Imagerie Médicale Agglomération Lille)

    Lille, 59700, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Centre Hospitalier St Joseph St Luc

    Lyon, 69365, France

  • Clinique Jules Verne

    Nantes, 44300, France

  • Clinique Urologique Nantes Atlantis

    Saint-Herblain, 44815, France

  • Groupe Hospitalier Pellegrin - CHU de Bordeaux

    Bordeaux, 33076, France

  • Hopital Pitie Salpetriere

    Paris, 75013, France

  • Hôpital Cochin

    Paris, 75014, France

  • Hôpital Edouard Herriot

    Lyon, 69437, France

  • Hôpital Européen Georges Pompidou

    Paris, 75015, France

  • Hôpital Huriez - CHU de Lille

    Lille, 59037, France

  • Hôpital Michallon - CHU de Grenoble

    Grenoble, 38043, France

  • Hôpital Necker

    Paris, 75015, France

  • Hôpital Privé La Louvière

    Lille, 59042, France

  • IRMAS

    Saint-Priest-en-Jarez, 42270, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut Universitaire du Cancer de Toulouse (IUCT) Oncopole - CHU de Toulouse

    Toulouse, 31059, France

  • Nouvel Hopital Civil - CHU de Strasbourg

    Strasbourg, 67091, France

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