MRI-Targeted biopsies may outshine standard needle probes for aggressive prostate cancer
NCT ID NCT02485379
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compared two ways to biopsy the prostate in 275 men with suspected cancer. The standard method takes random samples from the gland, which can miss aggressive tumors or find harmless ones. The new method uses MRI images to guide the needle to suspicious spots. The goal was to see if MRI-targeted biopsies catch more aggressive cancers (Gleason score 7 or higher) than the standard approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could make MRI-targeted biopsy the new standard for detecting aggressive prostate cancer, reducing missed diagnoses and unnecessary treatments.
- What could go wrong
- This is a completed diagnostic study, not a treatment trial. Results may not change practice if they show only modest improvement or if MRI is not widely available.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Nancy Brabois
Vandœuvre-lès-Nancy, 54511, France
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CHU de Saint-Etienne
Saint-Etienne, 42055, France
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CLIMAL (Centre Libéral Imagerie Médicale Agglomération Lille)
Lille, 59700, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69495, France
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Centre Hospitalier St Joseph St Luc
Lyon, 69365, France
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Clinique Jules Verne
Nantes, 44300, France
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Clinique Urologique Nantes Atlantis
Saint-Herblain, 44815, France
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Groupe Hospitalier Pellegrin - CHU de Bordeaux
Bordeaux, 33076, France
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Hopital Pitie Salpetriere
Paris, 75013, France
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Hôpital Cochin
Paris, 75014, France
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Hôpital Edouard Herriot
Lyon, 69437, France
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Hôpital Européen Georges Pompidou
Paris, 75015, France
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Hôpital Huriez - CHU de Lille
Lille, 59037, France
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Hôpital Michallon - CHU de Grenoble
Grenoble, 38043, France
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Hôpital Necker
Paris, 75015, France
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Hôpital Privé La Louvière
Lille, 59042, France
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IRMAS
Saint-Priest-en-Jarez, 42270, France
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Institut Paoli Calmettes
Marseille, 13273, France
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Institut Universitaire du Cancer de Toulouse (IUCT) Oncopole - CHU de Toulouse
Toulouse, 31059, France
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Nouvel Hopital Civil - CHU de Strasbourg
Strasbourg, 67091, France
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