New drug duo shows promise against tough prostate cancer

NCT ID NCT03910660

First seen Oct 31, 2025 · Last updated May 12, 2026 · Updated 28 times

Summary

This study tested a new oral drug (BXCL701) combined with an immunotherapy (pembrolizumab) in 98 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to find the right dose and see if the combo can shrink tumors or slow the disease. Participants had either small cell neuroendocrine or adenocarcinoma type prostate cancer.

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Contacts and locations

Locations

  • BioXcel Clinical Research Site

    Denver, Colorado, 80211, United States

  • BioXcel Clinical Research Site

    Detroit, Michigan, 48201, United States

  • BioXcel Clinical Research Site

    Glasgow, England, G12 0YN, United Kingdom

  • BioXcel Clinical Research Site

    London, Great Britain, W1T 7HA, United Kingdom

  • BioXcel Clinical Research Site

    Sutton, Surrey, SM2 5NG, United Kingdom

  • Center for Advanced Medicine / R.J. Zuckerberg Cancer Center (Northwell Health Cancer Institute)

    Lake Success, New York, 11042, United States

  • Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • University of California San Francisco (UCSF)

    San Francisco, California, 94158, United States

  • Weill Cornell Medicine New York

    New York, New York, 10021, United States

  • White Plains Hospital Center for Cancer Care

    White Plains, New York, 10601, United States

  • Yale University

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.