New pill combo aims to shrink tough prostate tumors
NCT ID NCT05617885
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests two oral drugs (darolutamide and abemaciclib) plus standard hormone therapy in men with high-risk prostate cancer that has spread or may come back. The first part finds the safest dose; the second checks if the combination can shrink or eliminate tumors before surgery. About 93 men will take part, with treatment lasting 6 months and follow-up up to 4.5 years.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Other studies related to the condition(s) this trial covers.
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