Could regular MRIs replace invasive biopsies for prostate cancer monitoring?

NCT ID NCT06280781

Recruiting now Knowledge-focused Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares regular MRI scans to standard care for men with low- to medium-risk prostate cancer who choose active surveillance (monitoring instead of immediate treatment). The goal is to see if MRIs can detect cancer progression earlier and more accurately, potentially reducing the number of biopsies and other tests. Over 1,200 participants will be followed for 5 years to measure cancer progression rates and cost-effectiveness for the NHS.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MRI scans
What this could lead to: If successful, regular MRI scans could become the new standard for monitoring low- to medium-risk prostate cancer, catching progression earlier and reducing the need for invasive biopsies.
What could go wrong: This is a large trial but still ongoing, and results may show that regular MRIs don't significantly improve detection or are not cost-effective for the NHS. MRI also has limitations and may miss some cancers.

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Conditions

The condition(s) this trial relates to.

prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

Bradford Royal Infirmary
RECRUITING

Bradford, United Kingdom
Charing Cross Hospital
RECRUITING

London, W6 8RF, United Kingdom
Darent Valley Hospital
RECRUITING

Dartford, Kent, DA2 8DA, United Kingdom
Freeman Hospital
RECRUITING

Newcastle upon Tyne, United Kingdom
Glan Clywd Hospital
RECRUITING

Rhyl, United Kingdom
Heatherwood Hospital
RECRUITING

Ascot, Berkshire, SL5 7GB, United Kingdom
Kings College London
RECRUITING

London, United Kingdom
North Cumbria
RECRUITING

Whitehaven, United Kingdom
Northern Lincolnshire and Goole NHS Foundation Trust
RECRUITING

Scunthorpe, United Kingdom
Southampton University Hospital
RECRUITING

Southampton, United Kingdom
St Peter's Hospital
RECRUITING

Chertsey, United Kingdom
West Middlesex Hospital
RECRUITING

London, United Kingdom

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