New radioactive cocktail aims to shrink tough prostate tumors

NCT ID NCT06855277

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether adding a radioactive drug called AAA817 to standard hormone therapy can slow cancer growth better than current treatments alone. About 940 men with PSMA-positive metastatic castration resistant prostate cancer will be randomly assigned to receive either AAA817 plus an ARPI (enzalutamide or abiraterone) or standard care. The study measures how long participants live without their cancer worsening and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AAA817 (a radioactive drug that targets prostate cancer cells) plus an androgen receptor pathway inhibitor (ARPI, a hormone-blocking drug)
What this could lead to: If successful, this combination could offer a new treatment option that delays cancer progression and extends survival for men with advanced prostate cancer that has stopped responding to hormone therapy.
What could go wrong: This is an early-stage Phase 3 trial, so results are not yet known. The radioactive treatment may cause side effects like bone marrow suppression or kidney damage, and not all participants may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC CASTRATION-RESISTANT PROSTATE CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

AdventHealth
RECRUITING

Orlando, Florida, 32804, United States
Associated Med Professionals of NY
RECRUITING

Syracuse, New York, 13210, United States
Astera Cancer Center
RECRUITING

East Brunswick, New Jersey, 08816, United States
Baptist Health South
RECRUITING

Miami, Florida, 33173, United States
Bassett Medical Center
RECRUITING

Cooperstown, New York, 13326, United States
Beth Israel Deaconess Med Center
RECRUITING

Boston, Massachusetts, 02215, United States
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Central Ohio Urology Group
RECRUITING

Gahanna, Ohio, 43230, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
East Jefferson Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Florida Cancer Specialists
RECRUITING

Fort Myers, Florida, 33901, United States
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
MUSC Hollings Cancer Center
RECRUITING

Charleston, South Carolina, 29425, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68154, United States
New Jersey Urology LLC
RECRUITING

Voorhees Township, New Jersey, 08043, United States
Northwest Medical Specialties
RECRUITING

Tacoma, Washington, 98405, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Novartis Investigative Site
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Novartis Investigative Site
RECRUITING

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site
RECRUITING

Malvern, Victoria, 3144, Australia
Novartis Investigative Site
RECRUITING

Murdoch, Western Australia, 6150, Australia
Novartis Investigative Site
RECRUITING

Adelaide, 5000, Australia
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 01308-050, Brazil
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 05652-000, Brazil
Novartis Investigative Site
RECRUITING

Fuzhou, Fujian, 350025, China
Novartis Investigative Site
RECRUITING

Guangzhou, Guangdong, 510120, China
Novartis Investigative Site
RECRUITING

Guangzhou, Guangdong, 510632, China
Novartis Investigative Site
RECRUITING

Wuhan, Hubei, 430022, China
Novartis Investigative Site
RECRUITING

Wuhan, Hubei, 430030, China
Novartis Investigative Site
RECRUITING

Nanjing, Jiangsu, 210006, China
Novartis Investigative Site
RECRUITING

Nanjing, Jiangsu, 210029, China
Novartis Investigative Site
RECRUITING

Shenyang, Liaoning, 110011, China
Novartis Investigative Site
RECRUITING

Chengdu, Sichuan, 610041, China
Novartis Investigative Site
RECRUITING

Hangzhou, Zhejiang, 310022, China
Novartis Investigative Site
RECRUITING

Beijing, 100034, China
Novartis Investigative Site
RECRUITING

Beijing, 100036, China
Novartis Investigative Site
RECRUITING

Guangzhou, 510060, China
Novartis Investigative Site
RECRUITING

Shanghai, 200025, China
Novartis Investigative Site
RECRUITING

Shanghai, 200032, China
Novartis Investigative Site
RECRUITING

Shanghai, 200127, China
Novartis Investigative Site
RECRUITING

Tianjin, 300300, China
Novartis Investigative Site
RECRUITING

Tianjin, 300480, China
Novartis Investigative Site
RECRUITING

Hong Kong, 999077, Hong Kong
Novartis Investigative Site
RECRUITING

Gurgaon, Haryana, 122 002, India
Novartis Investigative Site
RECRUITING

Bengaluru, Karnataka, 560066, India
Novartis Investigative Site
RECRUITING

Mumbai, Maharashtra, 400 012, India
Novartis Investigative Site
RECRUITING

Nagoya, Aichi-ken, 4668560, Japan
Novartis Investigative Site
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Novartis Investigative Site
RECRUITING

Kobe, Hyōgo, 650-0017, Japan
Novartis Investigative Site
RECRUITING

Kobe, Hyōgo, 6500047, Japan
Novartis Investigative Site
RECRUITING

Yokohama, Kanagawa, 236-0004, Japan
Novartis Investigative Site
RECRUITING

Chuo Ku, Tokyo, 1040045, Japan
Novartis Investigative Site
RECRUITING

Chiba, 260-8717, Japan
Novartis Investigative Site
RECRUITING

Fukuoka, 811-0213, Japan
Novartis Investigative Site
RECRUITING

Fukuoka, 812-0033, Japan
Novartis Investigative Site
RECRUITING

Fukuoka, 8128582, Japan
Novartis Investigative Site
RECRUITING

Fukushima, 9601295, Japan
Novartis Investigative Site
RECRUITING

Hiroshima, 7348551, Japan
Novartis Investigative Site
RECRUITING

Kyoto, 6068507, Japan
Novartis Investigative Site
RECRUITING

Singapore, 119074, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 168583, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 169608, Singapore
Novartis Investigative Site
RECRUITING

Seoul, 01812, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 03080, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 03722, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 05505, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 06351, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 06591, South Korea
Novartis Investigative Site
RECRUITING

Kaohsiung City, 833, Taiwan
Novartis Investigative Site
RECRUITING

Taipei, 10002, Taiwan
Novartis Investigative Site
RECRUITING

Taoyuan, 33305, Taiwan
Novartis Investigative Site
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Sansum Clinic
RECRUITING

Santa Barbara, California, 93105, United States
Stanford University Medical Center
RECRUITING

Palo Alto, California, 94304, United States
Swedish Medical Center
RECRUITING

Seattle, Washington, 98122-4379, United States
Tennessee Oncology PLLC
RECRUITING

Chattanooga, Tennessee, 37404, United States
Univ Of Iowa Hospitals And Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University Cancer and Blood Center LLC
RECRUITING

Athens, Georgia, 30607, United States
University of Kansas Hospital
RECRUITING

Kansas City, Kansas, 66160, United States
University of Rochester Medical Ctr
RECRUITING

Rochester, New York, 14642, United States
Urology Centers Of Alabama Pc
RECRUITING

Homewood, Alabama, 35209, United States
Urology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Wash U School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medicine NY-Presb
RECRUITING

New York, New York, 10021, United States
Woodlands Cancer Institute American Oncology Partners
RECRUITING

The Woodlands, Texas, 77384, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.