Can MRI outsmart blood tests for prostate cancer?
NCT ID NCT03784924
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study enrolls 950 men with suspected but undiagnosed prostate cancer who are scheduled for a biopsy. Researchers will compare the accuracy of prostate MRI against a panel of blood and urine biomarkers (PCA3, PSA, TMPRSS2:ERG) in detecting clinically significant prostate cancer (Gleason 7 or higher). The goal is to determine which method is better at identifying aggressive cancers in the initial biopsy setting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MRI prostate (diagnostic test) and laboratory biomarkers (PCA3, PSA, TMPRSS2:ERG)
What this could lead to
If successful, this could show that MRI is better than current biomarker tests at finding aggressive prostate cancer, helping men avoid unnecessary biopsies.
What could go wrong
This is an observational study, not a treatment trial. Results may not change practice immediately, and MRI may not prove superior to biomarkers in all cases.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••