Prostate cancer radiation showdown: SBRT vs. brachytherapy

NCT ID NCT06052683

Recruiting now Symptom relief Sponsor: CHU de Quebec-Universite Laval Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial compares two types of radiation therapy for low-risk prostate cancer: SBRT (a precise, high-dose external beam treatment) and low-dose rate brachytherapy (implanting radioactive seeds). The goal is to see which causes fewer urinary and bowel side effects and leads to a better quality of life. About 208 men with low or favorable intermediate-risk prostate cancer will be randomly assigned to one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (SBRT or low-dose rate brachytherapy with Iodine-125 seeds)
What this could lead to: If it works, this could show that SBRT causes fewer urinary and bowel side effects than brachytherapy, helping doctors choose the gentler option.
What could go wrong: This is a medium-sized trial comparing two established treatments, so no major breakthrough is expected. Results may not apply to higher-risk cancers.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

Centre Intégré de Cancérologie, CHU de Québec-Université Laval
RECRUITING

Québec, Quebec, G1J 1Z4, Canada

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