New radiation technique aims to spare the urethra in prostate cancer treatment

NCT ID NCT05804318

Recruiting now Disease control Sponsor: Varian, a Siemens Healthineers Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial is testing a daily adaptive radiation therapy for low to intermediate risk prostate cancer that spares the urethra. The goal is to reduce urinary side effects compared to standard radiation. About 132 participants will receive this tailored radiation, and their urinary quality of life will be tracked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: daily adaptive stereotactic body radiation therapy (SBRT) with urethral sparing
What this could lead to: If successful, this approach could reduce urinary side effects during radiation for prostate cancer, making treatment more tolerable.
What could go wrong: This is an early-phase trial with no control group, so results may not confirm benefit. The approach is complex and may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

Brigham and Women's Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02115, United States
City of Hope Orange County Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 92618, United States
Duarte Cancer Center
RECRUITING

Duarte, California, 91010, United States
Fox Chase Cancer Center
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Hospital Universitario de Navarra
RECRUITING

Pamplona, Navarre, 31008, Spain
Klinikum der Landeshauptstadt Stuttgart gKAöR
RECRUITING

Stuttgart, Baden-Wurttemberg, 70174, Germany
Universitätsklinikum des Saarlandes (Saarland Univerisity Hospital)
RECRUITING

Homburg, Saarland, 66421, Germany
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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