New hope for tough prostate cancer? early trial begins

NCT ID NCT05519449

Recruiting now Disease control Sponsor: Janux Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called JANX007 in men with advanced prostate cancer that has spread and stopped responding to standard treatments. The main goal is to check safety and find the right dose. About 272 men will take part across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JANX007 (an experimental biologic drug given by IV)
What this could lead to: If it works, this could point toward a new treatment option for advanced prostate cancer that has stopped responding to standard therapies.
What could go wrong: This is a very early Phase 1 trial focused on safety, not proof of effectiveness. It is small and may not lead to a working treatment. Side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer Prostatic Neoplasms, Castration-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CASTRATION-RESISTANT PROSTATIC CANCER METASTATIC CASTRATION RESISTANT PROSTATE CANCER PROSTATE CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Chris O'Brien Lifehouse (COBLH)
RECRUITING

Camperdown, New South Wales, 2050, Australia
Froedtert Hospital and the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92663, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Linear Clinical Research Ltd.
RECRUITING

Nedlands, Western Australia, 6009, Australia
Mary Crowley Cancer Research
RECRUITING

Dallas, Texas, 75230, United States
Massachusetts General Hospital
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Northwell Health R.J. Zuckerberg Cancer Hospital
RECRUITING

Lake Success, New York, 11042, United States
Oregon Health and Science University
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97239, United States
Penn State Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Sarah Cannon Research
RECRUITING

Nashville, Tennessee, 37203, United States
Southern Oncology Clinical Research Unit (SoCRU)
RECRUITING

Bedford Park, South Australia, 5042, Australia
Thomas Jefferson University Honickman Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCLA Department of Medicine
RECRUITING

Los Angeles, California, 90095, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94158, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
USC Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University of Alabama at Birmingham Hospital
RECRUITING

Birmingham, Alabama, 35249, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Minnesota Medical Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Wisconsin Carbone Cancer Center
RECRUITING

Madison, Wisconsin, 53792, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10065, United States
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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