New hope for Tough-to-Treat prostate cancer: experimental drug AAA817 faces off against standard care

NCT ID NCT06780670

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called AAA817 in adults with a specific type of advanced prostate cancer (PSMA-positive) that has worsened after prior treatments, including a targeted therapy. About 443 participants will be randomly assigned to receive either AAA817 or the doctor's choice of standard care. The goal is to see if AAA817 can slow cancer growth, improve survival, and have manageable side effects.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

AdventHealth
RECRUITING

Orlando, Florida, 32804, United States
Associated Med Professionals of NY
RECRUITING

Syracuse, New York, 13210, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Central Ohio Urology Group
RECRUITING

Gahanna, Ohio, 43230, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
East Jefferson Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109-1024, United States
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Medical College Of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68154, United States
New Jersey Urology LLC
RECRUITING

Voorhees Township, New Jersey, 08043, United States
Novartis Investigative Site
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Novartis Investigative Site
RECRUITING

Herston, Queensland, 4029, Australia
Novartis Investigative Site
RECRUITING

Melbourne, Victoria, 3004, Australia
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 01308-050, Brazil
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 05652-000, Brazil
Novartis Investigative Site
RECRUITING

Fuzhou, Fujian, 350025, China
Novartis Investigative Site
RECRUITING

Wuhan, Hubei, 430022, China
Novartis Investigative Site
RECRUITING

Wuhan, Hubei, 430030, China
Novartis Investigative Site
RECRUITING

Nanjing, Jiangsu, 210006, China
Novartis Investigative Site
RECRUITING

Nanjing, Jiangsu, 210029, China
Novartis Investigative Site
RECRUITING

Shenyang, Liaoning, 110011, China
Novartis Investigative Site
RECRUITING

Xian, Shanxi, 710032, China
Novartis Investigative Site
RECRUITING

Xian, Shanxi, 710061, China
Novartis Investigative Site
RECRUITING

Chengdu, Sichuan, 610041, China
Novartis Investigative Site
RECRUITING

Beijing, 100034, China
Novartis Investigative Site
RECRUITING

Beijing, 100036, China
Novartis Investigative Site
RECRUITING

Guangzhou, 510060, China
Novartis Investigative Site
RECRUITING

Shanghai, 200025, China
Novartis Investigative Site
RECRUITING

Shanghai, 200032, China
Novartis Investigative Site
RECRUITING

Tianjin, 300300, China
Novartis Investigative Site
RECRUITING

Hong Kong, 999077, Hong Kong
Novartis Investigative Site
RECRUITING

Beersheba, 8457108, Israel
Novartis Investigative Site
RECRUITING

Haifa, 3109601, Israel
Novartis Investigative Site
RECRUITING

Jerusalem, 9112001, Israel
Novartis Investigative Site
RECRUITING

Petah Tikva, 4941492, Israel
Novartis Investigative Site
RECRUITING

Ramat Gan, 5265601, Israel
Novartis Investigative Site
RECRUITING

Tel Aviv, 6423906, Israel
Novartis Investigative Site
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Novartis Investigative Site
RECRUITING

Sapporo, Hokkaido, 060-8648, Japan
Novartis Investigative Site
RECRUITING

Kobe, Hyōgo, 6500047, Japan
Novartis Investigative Site
RECRUITING

Yokohama, Kanagawa, 236-0004, Japan
Novartis Investigative Site
RECRUITING

Chiba, 260-8717, Japan
Novartis Investigative Site
RECRUITING

Fukuoka, 811-0213, Japan
Novartis Investigative Site
RECRUITING

Fukuoka, 812-0033, Japan
Novartis Investigative Site
RECRUITING

Fukuoka, 8128582, Japan
Novartis Investigative Site
RECRUITING

Fukushima, 9601295, Japan
Novartis Investigative Site
RECRUITING

Ishikawa, 9208641, Japan
Novartis Investigative Site
RECRUITING

Kyoto, 6068507, Japan
Novartis Investigative Site
RECRUITING

Petaling Jaya, Selangor, 46050, Malaysia
Novartis Investigative Site
RECRUITING

Petaling Jaya, Selangor, 46150, Malaysia
Novartis Investigative Site
RECRUITING

Singapore, 119228, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 168583, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 258499, Singapore
Novartis Investigative Site
RECRUITING

Seoul, 03080, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 03722, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 05505, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 06591, South Korea
Novartis Investigative Site
RECRUITING

Basel, 4031, Switzerland
Novartis Investigative Site
RECRUITING

Bellinzona, 6500, Switzerland
Novartis Investigative Site
RECRUITING

Bern, 3010, Switzerland
Novartis Investigative Site
RECRUITING

Taipei, 10002, Taiwan
Novartis Investigative Site
RECRUITING

Taipei, 103616, Taiwan
Novartis Investigative Site
RECRUITING

Taipei, 11217, Taiwan
Novartis Investigative Site
RECRUITING

Taoyuan, 33305, Taiwan
Saint Johns Cancer Institute
RECRUITING

Santa Monica, California, 90404, United States
Sansum Clinic
RECRUITING

Santa Barbara, California, 93105, United States
Stanford University Medical Center
RECRUITING

Palo Alto, California, 94304, United States
Texas Oncology
RECRUITING

Dallas, Texas, 75251, United States
University Cancer and Blood Center LLC
RECRUITING

Athens, Georgia, 30607, United States
University of Kansas Hospital
RECRUITING

Kansas City, Kansas, 66160, United States
Urology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Utah Intermountain Medical Center
RECRUITING

Murray, Utah, 84107, United States
VA Greater LA Healthcare System
RECRUITING

Los Angeles, California, 90073, United States
VA Palo Alto Health Care System
RECRUITING

Palo Alto, California, 94304-1207, United States
WA Uni School Of Med
RECRUITING

St Louis, Missouri, 63110, United States

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