Gene test + MRI may catch deadly prostate cancer earlier

NCT ID NCT06398639

Recruiting now Diagnosis Sponsor: Adam S. Kibel, MD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new way to screen for aggressive prostate cancer. Researchers will give 1,500 men aged 40-69 a genetic risk score, a PSA blood test, and a special MRI. The goal is to see if combining genetic risk with MRI can better identify high-grade cancers that could be fatal, while avoiding overdiagnosis of low-risk disease. Participants will be followed based on their risk level and test results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Polygenic Risk Score (genetic test) plus multiparametric MRI
What this could lead to: If successful, this could lead to a more accurate screening method that catches dangerous prostate cancers early while avoiding unnecessary biopsies.
What could go wrong: This is an early-stage observational study, not a treatment trial. The genetic test and MRI may not improve detection enough to change current practice, and results may not apply to all ethnic groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Genetic Risk Score prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYGENIC RISK SCORE PROSTATE CANCER

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02155, United States
Howard University Hospital
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20060, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
National Cancer Institute
NOT_YET_RECRUITING

Bethesda, Maryland, 20814, United States
Walter Reed National Military Medical Center
NOT_YET_RECRUITING

Bethesda, Maryland, 20814, United States

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