New drug cocktail shows promise for Hard-to-Treat gut cancers
NCT ID NCT04430738
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a drug called tucatinib combined with other cancer medicines (trastuzumab, chemotherapy, and pembrolizumab) in people with HER2-positive cancers of the digestive system. The main goals are to find safe doses and see what side effects occur. About 40 adults with advanced stomach, bowel, or gallbladder cancer are taking part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aichi Cancer Center Hospital
Nagoya, Aichi-ken, 464-8681, Japan
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Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
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Cancer Institute Hospital of Japanese Foundation for Cancer Research.
Koto-ku, Tokyo, 135-8550, Japan
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Duke University Medical Center, Duke Cancer Center
Durham, North Carolina, 27710, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Mayo Clinic
Scottsdale, Arizona, 85259, United States
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Mayo Clinic Hospital
Phoenix, Arizona, 85054, United States
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National Cancer Center Hospital
Chuo-ku, Tokyo, 104-0045, Japan
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National Cancer Center Hospital East
Kashiwa-shi, Chiba, 277-8577, Japan
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Osaka International Cancer Institute
Osaka, Osaka, 541-8567, Japan
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PCM Trials
Denver, Colorado, 80218, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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Siteman Cancer Center
St Louis, Missouri, 63108, United States
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Siteman Cancer Center - North County
Florissant, Missouri, 63031, United States
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Siteman Cancer Center - South County
St Louis, Missouri, 63129, United States
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Siteman Cancer Center - St Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - West County
Creve Coeur, Missouri, 63141, United States
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St. Marianna University Hospital
Kawasaki, Kanagawa, 216-8511, Japan
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University of Colorado Denver CTO(CTRC)
Aurora, Colorado, 80045, United States
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University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)
Aurora, Colorado, 80045, United States
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University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)
Aurora, Colorado, 80045, United States
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University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)
Aurora, Colorado, 80045, United States
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University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, 87131, United States
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University of Washington Medical Center
Seattle, Washington, 98195, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug combo shrink Hard-to-Treat tumors?
- A simple blood draw could spot colorectal cancer early
- A new test could reveal how radiation affects the liver
- Can immunotherapy outperform chemo after stomach cancer surgery?
- Could a smartphone program supervised by AI boost recovery after stomach cancer surgery?